Research Article

Related GMR Articles

-372C/G; -607A/C; Coronary artery disease; IL-18; Polymorphism

Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were ... more

J.B. Ma; L. Chen; B. Gao; J. Xu
ELOVL4 gene; PRPH2 gene; Stargardt disease

Stargardt disease (STGD) is an inherited genetic eye condition involving bilateral macular dystrophy leading to progressive central vision loss. It is the most common form of autosomal recessive juvenile macular dystrophy. In this study, ELOVL4 and PRPH2 genes were analyzed in 30 STGD probands for genetic variations using next-generation ... more

H. Bardak; M. Gunay; Y. Erçalık; Y. Bardak; H. Ozbas; O. Bagci; A. Ayata; M. Sönmez; C. Alagöz
High-resolution melting; Pinctada fucata; SNP; Transcriptome sequencing

The pearl oyster Pinctada fucata is an important commercial marine shellfish that is cultured for producing saltwater pearls. In this study, 468 single nucleotide polymorphisms (SNPs) were screened from P. fucata transcriptome data, and 119 polymorphic SNPs were successfully isolated by a two-step small-amplicon high-resolution melting assay. Of ... more

S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu; S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu; S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu
Autoimmunity; Nephropathy; Peripheral blood mononuclear cells; TIM-3

Increasing evidence shows that TIM-1 and TIM-3 in­fluence chronic autoimmune diseases, and their expression levels in immune cells from nephritic patients are still unknown. Real-time transcription-polymerase chain reaction analysis was used to deter­mine expression levels of TIM-1 and TIM-3 mRNA in peripheral blood mononuclear cells (PBMCs) from 36 patients with minimal change glo­ ... more

X.Z. Cai; N. Liu; Y. Qiao; S.Y. Du; Y. Chen; D. Chen; S. Yu; Y. Jiang
Cardiomyocyte-like cells; Cell differentiation; Mesenchymal stem cells; Rehmannia glutinosa oligosaccharide

The aim of this study was to observe the effect of Rehmannia glutinosa oligosaccharide (RGO) on differentiation of bone marrow mesenchymal stem cells (MSCs) into cardiomyocyte-like cells . Rat MSCs were isolated, treated, and grouped as follows: RGO treatment group, 5-azacytidine (5-aza) treatment group, RGO + 5-aza treatment group, and control group. ... more

X.H. Wang; H.W. Du; X.H. Guo; S.W. Wang; R.B. Zhou; Y. Li; Z.B. Li; Y.S. Zhao; Q.L. Zhu
Clinically negative node; Meta-analysis; Radical neck dissection; Radiotherapy; Supraglottic carcinoma

The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were “supraglottic carcinoma”, “cervical lymph nodes negative/cN0”, “radical neck dissection”, and “radiotherapy”. The databases included the Chinese biomedical literature database, Medline, Cochrane ... more

Y.H. Liu; Z.W. Du
Caspase-3; Citrate; Ventricular arrhythmia

Ischemia/reperfusion (I/R) injury often triggers ventricular arrhythmia. Citrate binds calcium ions, forming a soluble calcium citrate complex that may reduce I/R injury by affecting calcium ion concentration. We tested the effects of citrate pretreatment on ventricular heart rate and related factors in a rat I/R model. Fifty male Sprague Dawley rats weighing 350- ... more

Q. Lu; Z.G. Li; N. Zhou; Z.G. Gong; J.Q. Jiang; Z.N. Chen; Q.J. Jiang; Y. Peng; S.F. Ding
Apoptosis; C-erbB-2; Chitosan; Laryngeal cancer; Nanoparticles

We aimed to measure the invasion ability of Hep-2 laryngeal cancer cells after treatment with C-erbB-2-small interfering RNA (siRNA)-chitosan nanoparticles, and assess the applied value of chitosan nanoparticle-mediated C-erbB-2 interference in inhibiting laryngeal cancer invasion and metastasis. Nanoparticles of approximately 100 nm, comprising ... more

W.R. Liu; L.R. Cao; G.J. Zuo; W.R. Liu; L.R. Cao; G.J. Zuo
Arf; Endothelial barrier function; Heart failure; IL-1β; SC514

To preliminarily clarify the mechanism of cardiac microvascular endothelial barrier function leading to heart failure, primary HMVEC-D cells were selected and cultured for amplification. The cells were infected with adenovirus vector containing the ADP-ribosylation factor 6 (Arf6) Q67L gene. Full-length and functional fragments of myeloid differentiation ... more

W. Dong; G.N. Zhang; S.H. Gao; W. Dong; G.N. Zhang; S.H. Gao; W. Dong; G.N. Zhang; S.H. Gao
Bipolar disorder; Klinefelter syndrome; Sex chromosomal disorder

Klinefelter syndrome (KS) is the most common sex chromosomal disorder with an estimated prevalence of 1 in 500-1000. Increased incidences of anxiety, depression, substance abuse, psychotic and behavioral disorders, and sexual disorders have been reported in patients with KS. The aim of this case study was to report a case of a man with untreated KS who was also ... more

H. Delavenne; J.M. Khoury; F. Thibaut; F.D. Garcia