Research Article

Related GMR Articles

10/17/2016
-1082A/G; -592A/C; CAD; IL-10; Polymorphism

Here, we conducted a case-control study to investigate the association between IL-10 gene polymorphisms and development of CAD in a Chinese population. A total of 220 patients with CAD and 236 control subjects who visited the Zhengzhou People’s Hospital between May 2012 and June 2014 were selected for this study. The IL-10-1082A/G and -592A/C ... more

L. Wu; M.H. Zhao; G.Y. Geng; L. Mao; H.J. Liu
10/17/2016
IL-8; Polymorphism; Primary gouty arthritis; rs2227306; rs4073

In this study, we investigated the role of two single nucleotide polymorphisms in the promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility to primary gouty arthritis in a Chinese population. Three hundred and twelve patients with primary gouty arthritis and 340 healthy controls were recruited from the Yan’an ... more

Y.X. Cui; H. Zhao; H.Q. Guo
10/17/2016
Atrial fibrillation; Connexin 40; Gene polymorphism

We aimed to elucidate the association between connexin 40 (Cx40) genetic polymorphisms and atrial fibrillation (AF) in a Chinese population in Xinjiang comprising Uyghur and Han individuals. We enrolled 275 Uyghur and 305 age- and gender-matched Han subjects, and used polymerase chain reaction to detect single nucleotide polymorphisms (SNPs; -44G/A and +71A/G) in ... more

J. Hailati; Y.C. Yang; L. Zhang; P.Y. He; M. Baikeyi; W. Muhuyati; Z.Q. Liu
10/17/2016
Admixed population; African ancestry; Amerindian ancestry; Ancestry informative markers; European ancestry; Single nucleotide polymorphism

Some studies of polymorphisms in prostate cancer (PCa) analyze individuals in a uniform manner, regardless of genetic ancestry. However, PCa aggressiveness differs between subjects of African descent and those of European extraction. Thus, genetic ancestry analysis may be used to detect population stratification in case-control association studies. We genotyped 11 ... more

J.S. Oliveira; R.S. Ferreira; L.M. Santos; L.J. Marin; R.X. Corrêa; M.R. Luizon; A.L. Simões; S.R. Gadelha; S.M.B. Sousa
10/17/2016
Ankylosing spondylitis; IL-4 rs2227282; IL-4 rs2243250; Interleukin-4; Serum levels; Single nucleotide polymorphism

We aimed to investigate the effect of two common polymorphisms in interleukin-4 (IL-4) on serum IL-4 levels and the development of ankylosing spondylitis (AS) in the Chinese population. A total of 420 inpatients and outpatients diagnosed with AS were enrolled as the case group, and 330 healthy volunteers were selected as the control group. IL-4 ... more

X.L. Liu; J.K. Ren; Y.L. Su
10/17/2016
Congenital heart disease; MicroRNA; miR-196a2; Single nucleotide polymorphisms

We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs895819), and miR-499 (rs3746444). Allele ... more

K. Yu; Y. Ji; H. Wang; Q.K. Xuan; B.B. Li; J.J. Xiao; W. Sun; X.Q. Kong
10/24/2016
Gene polymorphism; Osteoarticular tuberculosis; Prognosis; Tumor necrosis factor-α

This study investigated the association of tumor necrosis factor-α (TNF-α)-308, -238, and -863 polymorphisms with osteoarticular tuberculosis (OA-TB) prognosis in a Hebei population. Genomic DNA was extracted from venous blood samples of 120 OA-TB patients and 100 healthy volunteers. TNF-α-308, -238, and -863 were analyzed by PCR-restriction ... more

Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang; Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang; Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang
10/24/2016
4b/a (VNTR); eNOS polymorphisms; Fabry disease; Glu298Asp; Kidney disease; Renal function parameters

Fabry disease (FD) is an inherited X-linked lysosomal disease that causes renal failure in a high percentage of affected individuals. The eNOS gene encodes for endothelial nitric oxide synthase, which plays an important role in glomerular hemodynamics. This gene has two main polymorphisms (Glu298Asp and 4b/a) that have been studied in the context of many ... more

A. Marin-Medina; A.J.L. Brambila-Tapia; V.J. Picos-Cárdenas; M.P. Gallegos-Arreola; L.E. Figuera
10/24/2016
IFIH1; Meta-analysis; SLE; SLE clinical manifestations; SNPs

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C ... more

deAzevêdo Silva; S.C. Lima; C. Addobbati; R. Moura; L.A.Cavalcanti Brandão; J.A.Trés Pancoto; E.A. Donadi; S. Crovella; P. Sandrin-Garcia
10/24/2016
-372C/G; -607A/C; Coronary artery disease; IL-18; Polymorphism

Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were ... more

J.B. Ma; L. Chen; B. Gao; J. Xu

Pages