Research Article

Related GMR Articles

Bacterial killing; CD209a; Helicobacter pylori; LECT2; Macrophages; NF-κB

Helicobacter pylori employs unique methods to colonize the stomach, which induces chronic inflammation. It is also able to avoid eradication by macrophages and other immune cells. Leukocyte cell-derived chemotaxin 2 (LECT2), a multi-functional cytokine involved in many pathological conditions, has recently been shown to activate macrophages via the CD209a ... more

H.X. Shen; L. Li; Q. Chen; Y.Q. He; C.H. Yu; C.Q. Chu; X.J. Lu; J. Chen
Chondrocyte; Ginkgo biloba extract; IL-1β; Matrix metalloproteinase

A rat model with cartilage chondrocyte injury was established using interleukin-1β (IL-1β) to investigate the effect of Ginkgo biloba extract (EGb) on matrix metalloproteinase-3 (MMP-3) expression. Rat chondrocytes were extracted and randomly divided into six groups: control group, IL-1β (model) group, IL-1β + dexamethasone group, and IL-1β + EGb group (both high and low dose ... more

J.Z. Zeng; L.F. Ma; H. Meng; H.M. Yu; Y.K. Zhang; A. Guo
AT1R; Gene polymorphism; Heart failure; Meta-analysis

The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the ... more

J.A. Zhang; J.R. Li; Y.J. Qiao
Atorvastatin; Heart failure; Inflammatory cytokine; NT-proBNP

The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) and observation (N = 62) groups; the former received ... more

H.Y. Duan; D.M. Liu; P. Qian; S.L. Wang; L.J. Yan; J.T. Wu; H.T. Yang; X.W. Fan; Y.J. Chu
Cardiomyocytes; Heart failure; Mice; Protein 4.1R

We aimed to assess the protein 4.1R (4.1R) expression of the membrane skeleton in cardiomyocytes and to determine the potential role of 4.1R in the pathogenesis of heart failure (HF). Forty-two male mice were randomly divided into two groups: an HF group (N = 22) and control group (N = 20). The HF model was established by abdominal subcutaneous injection of 5 mg⋅kg-1⋅day-1 ... more

Z. Wei; G. Yang; R. Xu; C. Zhu; F. He; Q. Dou; J. Tang; Z. Wei; G. Yang; R. Xu; C. Zhu; F. He; Q. Dou; J. Tang
Bayesian inference; Gibbs sampling; Heart failure; Markov chain Monte Carlo; Molecular functions

We identified disturbed pathways in heart failure (HF) based on Gibbs sampling combined with pathway enrichment analysis. A total of 396 Markov chains (MCs) (gene count >5) were obtained. After Gibbs sampling, six differentially expressed molecular functions (DEMFs) (possibility ≥0.8) were obtained. As statistical analysis was performed on the number of individual differentially ... more

P. Chen; L.H. Guo; Y.K. Guo; Z.J. Qu; Y. Gao; H. Qiu; P. Chen; L.H. Guo; Y.K. Guo; Z.J. Qu; Y. Gao; H. Qiu
Cardiomyocyte-like cells; Cell differentiation; Mesenchymal stem cells; Rehmannia glutinosa oligosaccharide

The aim of this study was to observe the effect of Rehmannia glutinosa oligosaccharide (RGO) on differentiation of bone marrow mesenchymal stem cells (MSCs) into cardiomyocyte-like cells . Rat MSCs were isolated, treated, and grouped as follows: RGO treatment group, 5-azacytidine (5-aza) treatment group, RGO + 5-aza treatment group, and control group. ... more

X.H. Wang; H.W. Du; X.H. Guo; S.W. Wang; R.B. Zhou; Y. Li; Z.B. Li; Y.S. Zhao; Q.L. Zhu
-1082A/G; -592A/C; CAD; IL-10; Polymorphism

Here, we conducted a case-control study to investigate the association between IL-10 gene polymorphisms and development of CAD in a Chinese population. A total of 220 patients with CAD and 236 control subjects who visited the Zhengzhou People’s Hospital between May 2012 and June 2014 were selected for this study. The IL-10-1082A/G and -592A/C ... more

L. Wu; M.H. Zhao; G.Y. Geng; L. Mao; H.J. Liu
Clinically negative node; Meta-analysis; Radical neck dissection; Radiotherapy; Supraglottic carcinoma

The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were “supraglottic carcinoma”, “cervical lymph nodes negative/cN0”, “radical neck dissection”, and “radiotherapy”. The databases included the Chinese biomedical literature database, Medline, Cochrane ... more

Y.H. Liu; Z.W. Du
Cancer cell proliferation; Lung cancer; miR-129b; Non-small cell lung carcinoma

Lung cancer is one of the most prevalent malignant tumors, and is one of the primary causes of cancer-associated deaths. In 2002, an estimated 1.18 million lung cancer-associated deaths were recorded, accounting for 18% of cancer-related deaths and 2% of total mortality. Despite the great progress that has been made in lung cancer therapies, the mechanisms ... more

L. Zheng; Y.X. Qi; S. Liu; M.L. Shi; W.P. Yang