Research Article

Related GMR Articles

10/24/2016
IFIH1; Meta-analysis; SLE; SLE clinical manifestations; SNPs

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C ... more

deAzevêdo Silva; S.C. Lima; C. Addobbati; R. Moura; L.A.Cavalcanti Brandão; J.A.Trés Pancoto; E.A. Donadi; S. Crovella; P. Sandrin-Garcia
10/24/2016
-372C/G; -607A/C; Coronary artery disease; IL-18; Polymorphism

Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were ... more

J.B. Ma; L. Chen; B. Gao; J. Xu
10/24/2016
Biomarker; Env; Gag; HIV; Molecular epidemiology; Pol

HIV genotyping has led to conflicting results between laboratories. Therefore, identifying the most accurate gene combinations to sequence remains a priority. Datasets of Chinese HIV subtypes based on several markers and deposited in PubMed, Metstr, CNKI, and VIP databases between 2000 and 2015 were studied. In total, 9177 cases of amplification-positive samples ... more

L. Ren; H.W. Wang; Y. Xu; Y. Feng; H.F. Zhang; K.H. Wang
10/24/2016
ELOVL4 gene; PRPH2 gene; Stargardt disease

Stargardt disease (STGD) is an inherited genetic eye condition involving bilateral macular dystrophy leading to progressive central vision loss. It is the most common form of autosomal recessive juvenile macular dystrophy. In this study, ELOVL4 and PRPH2 genes were analyzed in 30 STGD probands for genetic variations using next-generation ... more

H. Bardak; M. Gunay; Y. Erçalık; Y. Bardak; H. Ozbas; O. Bagci; A. Ayata; M. Sönmez; C. Alagöz
10/24/2016
Autoimmunity; CD40; qPCR; Rheumatoid arthritis; SNP

The CD40 pathway is involved in the development and pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression at the mRNA and protein level ... more

I.V. Román-Fernández; D.F. Ávila-Castillo; S. Cerpa-Cruz; S. Gutiérrez-Ureña; J. Hernández-Bello; J.R. Padilla-Gutiérrez; Y. Valle; M.G. Ramírez-Dueñas; A.L. Pereira-Suárez; J.F. Muñoz-Valle
10/17/2016
Aspergillus spp; Cellulolytic enzyme genes; Fermentation; RT-PCR

Fermentation is an important industrial process for microbial metabolite development and has wide applications in various fields. Aspergillus is the most important genus of fungi used for the production of microbial enzymes such as cellulase. The Aspergillus genome encodes various cellulolytic enzymes. In this study, we assayed the gene expression ... more

M.A. Mahmoud; M.R. Al-Othman; A. -El-Aziz; H.A. Metwaly; H.A. Mohamed
11/03/2016
Expression analysis; Gene cloning; Mussel; Mytilus coruscus; Wnt7b gene

To understand the potential functions of Wnt7b in different developmental stages and adult tissues of the mussel Mytilus coruscus, the Wnt7b gene was cloned using the rapid amplification of cDNA ends technique. The full-length Wnt7b gene was 1910 bp long, with a 1059-bp open reading frame encoding 352 amino acids. The amino acid sequence of the M. ... more

Y.F. Xu; X. Liang; Y.R. Chen; Y.F. Li; J.L. Yang; Y.F. Xu; X. Liang; Y.R. Chen; Y.F. Li; J.L. Yang
11/03/2016
Cis-elements; Differential expression; Low temperature; Oryza sativa L.; Reactive oxygen species; Salinity

Different rice (Oryza sativa L.) genotypes were subjected to high salinity and low temperature (150 mM NaCl and 13°C, respectively) for 0, 6, 24, 48, or 72 h. We evaluated the simultaneous expression of the genes OsCATA, OsCATB, and OsCATC, correlated gene expression with enzyme activity, and verified the regulation of these ... more

I.L. Vighi; L.C. Benitez; M.Ndo Amaral; P.A. Auler; G.P. Moraes; G.S. Rodrigues; L.C. da Maia; L.S. Pinto; E.J.B. Braga; I.L. Vighi; L.C. Benitez; M.Ndo Amaral; P.A. Auler; G.P. Moraes; G.S. Rodrigues; L.C. da Maia; L.S. Pinto; E.J.B. Braga
11/03/2016
Abiotic stress; Agrostis stolonifera; AsACO; Ethylene biosynthesis

A gene encoding 1-aminocyclopropane-1-carboxylic oxidase (ACO), which catalyzes the terminal step in ethylene biosynthesis, was isolated from Agrostis stolonifera. The AsACO gene is composed of 975 bp, encoding 324 amino acids. Three exons interspersed by two introns form AsACO gDNA. A BLAST search of the nucleotide sequence revealed a ... more

G.Z. Xiao; L.J. Li; K. Teng; Y.H. Chao; L.B. Han; G.Z. Xiao; L.J. Li; K. Teng; Y.H. Chao; L.B. Han
11/03/2016
CG15269; CG15436; Crol; PARIS; PGC-1α; Spargel

Mitochondrial destruction leads to the formation of reactive oxygen species, increases cellular stress, causes apoptotic cell death, and involves a cascade of proteins including PARKIN, PINK1, and Mitofusin2. Mitochondrial biogenesis pathways depend upon the activity of the protein PGC-1α. These two processes are coordinated by the ... more

E.M. Merzetti; B.E. Staveley

Pages