Research Article

Related GMR Articles

10/17/2016
Bipolar disorder; Klinefelter syndrome; Sex chromosomal disorder

Klinefelter syndrome (KS) is the most common sex chromosomal disorder with an estimated prevalence of 1 in 500-1000. Increased incidences of anxiety, depression, substance abuse, psychotic and behavioral disorders, and sexual disorders have been reported in patients with KS. The aim of this case study was to report a case of a man with untreated KS who was also ... more

H. Delavenne; J.M. Khoury; F. Thibaut; F.D. Garcia
10/17/2016
Brazilian red pepper essential oil; Ex vivo; Intestinal alkaline phosphatase; Intestinal explants; Sodium butyrate; Swine

In this study, we evaluated the effect of intestinal alkaline phosphatase (IAP) and sodium butyrate (NaBu) on lipopolysaccharide (LPS)-induced intestinal inflammation. Intestinal alkaline phosphatase and RelA/p65 (NF-κB) gene expressions in porcine jejunum explants were evaluated following exposure to sodium butyrate (NaBu) and essential oil from Brazilian red ... more

A.D.B. Melo; H. Silveira; C. Bortoluzzi; L.J. Lara; C.A.P. Garbossa; G. Preis; L.B. Costa; M.H. Rostagno
10/17/2016
Ankylosing spondylitis; IL-4 rs2227282; IL-4 rs2243250; Interleukin-4; Serum levels; Single nucleotide polymorphism

We aimed to investigate the effect of two common polymorphisms in interleukin-4 (IL-4) on serum IL-4 levels and the development of ankylosing spondylitis (AS) in the Chinese population. A total of 420 inpatients and outpatients diagnosed with AS were enrolled as the case group, and 330 healthy volunteers were selected as the control group. IL-4 ... more

X.L. Liu; J.K. Ren; Y.L. Su
10/17/2016
Congenital heart disease; MicroRNA; miR-196a2; Single nucleotide polymorphisms

We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs895819), and miR-499 (rs3746444). Allele ... more

K. Yu; Y. Ji; H. Wang; Q.K. Xuan; B.B. Li; J.J. Xiao; W. Sun; X.Q. Kong
10/17/2016
Endoplasmic reticulum stress; High glucose; Rosuvastatin

It is well established that endothelial injury plays an essential role in atherosclerotic plaque formation. Accumulating evidence has shown that high glucose levels may detrimentally affect cultured endothelial cells through endoplasmic reticulum (ER) stress. In this study, we investigated the effect of rosuvastatin on high glucose-induced ER stress in human ... more

J.Z. Xu; Y.L. Chai; Y.L. Zhang
10/17/2016
Balanced translocation; Breakpoint; Chromosome 7; Genetic counseling; Male infertility

Balanced reciprocal translocations are associated with reproductive failure. Some reciprocal translocation carriers exhibit azoospermia or oligozoospermia, and an association exists between these chromosomal abnormalities and recurrent abortion. Previous reports have indicated the involvement of chromosome 7 translocations in male infertility and recurrent ... more

R.X. Wang; H.G. Zhang; Y. Pan; J.H. Zhu; F.G. Yue; L.T. Xue; R.Z. Liu; R.X. Wang; H.G. Zhang; Y. Pan; J.H. Zhu; F.G. Yue; L.T. Xue; R.Z. Liu
10/24/2016
Gene polymorphism; Osteoarticular tuberculosis; Prognosis; Tumor necrosis factor-α

This study investigated the association of tumor necrosis factor-α (TNF-α)-308, -238, and -863 polymorphisms with osteoarticular tuberculosis (OA-TB) prognosis in a Hebei population. Genomic DNA was extracted from venous blood samples of 120 OA-TB patients and 100 healthy volunteers. TNF-α-308, -238, and -863 were analyzed by PCR-restriction ... more

Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang; Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang; Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang
10/24/2016
4b/a (VNTR); eNOS polymorphisms; Fabry disease; Glu298Asp; Kidney disease; Renal function parameters

Fabry disease (FD) is an inherited X-linked lysosomal disease that causes renal failure in a high percentage of affected individuals. The eNOS gene encodes for endothelial nitric oxide synthase, which plays an important role in glomerular hemodynamics. This gene has two main polymorphisms (Glu298Asp and 4b/a) that have been studied in the context of many ... more

A. Marin-Medina; A.J.L. Brambila-Tapia; V.J. Picos-Cárdenas; M.P. Gallegos-Arreola; L.E. Figuera
10/24/2016
-372C/G; -607A/C; Coronary artery disease; IL-18; Polymorphism

Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were ... more

J.B. Ma; L. Chen; B. Gao; J. Xu
10/24/2016
Biomarker; Env; Gag; HIV; Molecular epidemiology; Pol

HIV genotyping has led to conflicting results between laboratories. Therefore, identifying the most accurate gene combinations to sequence remains a priority. Datasets of Chinese HIV subtypes based on several markers and deposited in PubMed, Metstr, CNKI, and VIP databases between 2000 and 2015 were studied. In total, 9177 cases of amplification-positive samples ... more

L. Ren; H.W. Wang; Y. Xu; Y. Feng; H.F. Zhang; K.H. Wang

Pages