Related GMR Articles

6-biphosphatase 3; 6-Phosphofructo-2-kinase/fructose-2; miR-26b; Oncogene; Osteosarcoma

MicroRNAs regulate target gene expression and are involved in cell proliferation, apoptosis, differentiation, tumor invasion, and cancer stem cell regulation, among other processes. MicroRNA-26b (miR-26b) is closely related to tumor occurrence and development. In this study, we analyzed miR-26b expression in osteosarcoma tissue, its effect on Saos-2 osteosarcoma cell proliferation and invasion ... more

W.D. Zheng; F.L. Zhou; N. Lin
Osteosarcoma; Polymorphism; Vascular endothelial growth factor

We conducted a case-control study to assess the role of vascular endothelial growth factor (VEGF) -634G/C, +936C/T, and +1612G/A genetic variations in the development of osteosarcoma in a Chinese population. This hospital-based case-control study examined 130 patients with osteosarcoma and 130 age- and gender-matched healthy controls from March 2011 and March 2013. Polymerase ... more

G.L. Hu; G. Ma; J.H. Ming
Cytotoxic T lymphocytes; Dendritic cells; Immunotherapy; Osteosarcoma

The aim of this study was to investigate the effects of dendritic cell (DC) therapy in osteosarcoma. Bone marrow DCs from Wistar (allograft group) and Sprague Dawley (SD) (homograft group) rats were electrically fused with the SD-derived osteosarcoma cell line UMR106 to generate a DC-osteosarcoma fusion (DOF) tumor vaccine, which was co-incubated with SD T lymphocytes to stimulate T cell ... more

X. Fang; C. Jiang; Q. Xia
Apoptosis; Invasion; MicroRNA-9; Migration; Osteosarcoma; Proliferation

MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to that in a human osteoblastic cell ... more

X.J. Qi; J.F. Wang; G.D. Wang; Q. Xu; H.L. Sun; X.J. Qi; J.F. Wang; G.D. Wang; Q. Xu; H.L. Sun; X.J. Qi; J.F. Wang; G.D. Wang; Q. Xu; H.L. Sun
Adult; Aged; Apoptosis; Bone neoplasms; Caspase 8; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; male; Middle Aged; Osteochondroma; Osteosarcoma; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Young Adult

Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. Caspase-8 appears in the upstream of apoptosis signaling pathway among caspases. We investigated TRAIL and caspase-8 levels in osteosarcoma patients to determine their correlation with ... more

X. Ning; X.W. Shang; Y. Zhuang; M. Liu; H. Yang; H. Zhang; M.Z. Huang
Gastric cancer; Invasion; miR-221; Proliferation; Propofol

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel ... more

Z.T. Wang; H.Y. Gong; F. Zheng; D.J. Liu; X.Q. Yue
Invasion; miR-133a; Pancreatic cancer; Proliferation; Propofol

Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion ... more

Z.T. Wang; H.Y. Gong; F. Zheng; D.J. Liu; T.L. Dong
Invasion; MMP-8; Pituitary adenoma; TIMP-1

Pituitary adenomas can cause endocrine disorder and organ damage, with some aggressive ones leading to a high postoperative recurrence rate. The occurrence and development of these type of tumors is closely related with matrix metalloproteinases (MMPs) and endogenous specific tissue inhibitor of MMPs (TIMPs). In this study, the relationship between pituitary adenoma invasion and the ... more

J.H. Mao; H. Guo; N. Si; L. Qiu; L.F. Guo; Z.S. Sun; Y. Xiang; X.H. Yang; W.G. Zhao; W.C. Zhang
CapG; Cell growth; Invasion; Metastasis; Prostate cancer; RNA interference

This study investigated CapG gene expression in prostate cancer cell lines; in addition, we explored the effects of CapG suppression on DU145 cell growth, and the underlying mechanism with which CapG affects DU145 cell growth and invasiveness. The expression of CapG and 18 related genes in DU145 cells was analyzed by flow cytometry, quantitative polymerase chain reaction (qPCR), ... more

B.K. Li; K. Guo; C.Y. Li; H.L. Li; P.P. Zhao; K. Chen; C.X. Liu
Apoptosis; Invasion; MicroRNA-210 (miR-210); Proliferation; Renal cell carcinoma

This study investigated the expression of microRNA-210 (miR-210) in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion. Thirty-two renal carcinoma patients in our hospital were selected as the study group and 32 people receiving a physical examination were selected as the control group. miR-210 expression in the serum ... more

T.Y. Liu; H. Zhang; S.M. Du; J. Li; X.H. Wen; T.Y. Liu; H. Zhang; S.M. Du; J. Li; X.H. Wen