Research Article

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Diabetic retinopathy; Single nucleotide polymorphism; Type 2 diabetes

Retinoid-X receptor (RXR) is one of the members of the nuclear hormone receptor superfamily. It forms heterodimers with many nuclear receptors, such as the peroxisome proliferative-activated receptor, which has been proposed to be involved in diabetic complications, including retinopathy. A recent study revealed that RXR-alpha has antioxidant properties and is associated with diabetic ... more

C.H. Hsieh; D. Pei; Y.J. Hung; F.C. Hsiao
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Diabetic retinopathy; Systematic review; TCF7L2; Transcription factor 7-like 2 polymorphisms

The global prevalence of type 2 diabetes mellitus (T2DM) has increased, as well as complications including diabetic retinopathy. Polymorphisms in transcription factor 7-like 2 (TCF7L2) have been associated with T2DM, with the strongest association attributed to the single-nucleotide polymorphism rs7903146. In this review, we searched the current literature to determine ... more

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Atorvastatin; Diabetic retinopathy; Vascular endothelial growth factor; Vascular endothelial growth inhibitor; Wistar rats

We investigated the effect of atorvastatin on vascular endothelial growth inhibitor (VEGI) expression in rats with diabetic retinopathy. Wistar rats were divided into a blank group and diabetic model group, which was further randomly divided into treatment and control groups. Rats in the treatment group received 10 mg/kg atorvastatin daily, while rats in the blank and control groups received ... more

M.C. Bi; X.J. Song; H. Shi; W.X. Xue; C.L. Xu; E. Song
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Diabetic retinopathy; Retinal ganglion cells; TLR-4; Toll-like receptor-2

Diabetic retinopathy (DR), a major complication of diabetes mellitus, is the leading cause of adult blindness. The Toll-like receptor (TLR) family is believed to be involved in the pathogenesis and progression of DR. Here, we investigated the expression profiles of TLR-2 and TLR-4 in retinal ganglion cells (RGCs), in an attempt to elucidate the role of these molecules in the etiology of ... more

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Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes, and one of the most common causes of legal blindness in the world. Epigallocatechin-3-gallate (EGCG) produces an anti-oxidative and anti-inflammatory effect against various human diseases. In this study, we determined the effect of EGCG on a human retinal endothelial cell (HREC) line. The cell viability was ... more

L. Zhang; Z.K. Zhang; S. Liang; L. Zhang; Z.K. Zhang; S. Liang
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Diabetic retinopathy; Inflammatory cytokines; Ozone treatment; VEGF

The aim of this study was to investigate the effect of ozone on inflammatory cytokines in diabetic retinopathy (DR) rats. Male rats (40) weighing 300-360 g were included in this study. Thirty rats were randomly divided into the model and ozone groups after DR was induced by streptozotocin. Ten rats served as the blank group. After the diabetic models were established for one month, the ... more

T.Y. Xie; W. Yan; J. Lou; X.Y. Chen; T.Y. Xie; W. Yan; J. Lou; X.Y. Chen