Research Article

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11/03/2016
Apoptosis; miR-1; Proliferation; Vestibular schwannoma

A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover, miR-1 ... more

S.L. Li; X.H. Ma; J.F. Ji; H. Li; W. Liu; F.Z. Lu; S.T. Wu; Y. Zhang
11/30/2020
Apoptosis; CA 19-9; miRNAs; Pancreatic ductal adenocarcinoma

Pancreatic adenocarcinoma (PA) is one of the most aggressive malignant tumors of the digestive tract, with a five-year survival rate of 5%. Early detection offers better possibilities of cure; however, in early stages it does not present symptoms, making the management of these patients difficult. The most commonly used biomarker for diagnosis of PA is serum CA19-9 ... more

V.B. Filiputti; M.L.A. Cirino; F.S.Lizarte Neto; P.C. Novais; L.P. Turra; M.F.G.S. Tazima; F.M. Peria; D.P.C. Tirapelli; R. Kemp; J.Sdos Santos; A.K. Sankarankutty
09/28/2015
Bifidobacteria; Enterocolitis; Necrotizing; Newborn; Rats; Toll-like receptor

We established a necrotizing enterocolitis (NEC) rat model and explored the role of bifidobacteria in the intestines of the rats and its regulation on intestinal Toll-like receptors (TLRs). Seventy-five newborn Sprague-Dawley rats were randomly divided into 5 groups (15 rats/group): group A, artificial feeding group (formula-fed); group B, NEC model (LPS + formula-fed); group C, ... more

W. Zhou; H. Lv; M.X. Li; H. Su; L.G. Huang; J. Li; W.M. Yuan
04/28/2016
Fluid resuscitation; Hemorrhagic shock; MDSCs; Myeloid-derived suppressor cells; Rats

We investigated the influence of different fluid resuscitation techniques on the number of myeloid-derived suppressor cells (MDSCs) in rats. Seventy-two healthy Sprague-Dawley rats were randomly divided into groups that received sham operation (Sham group), hypertonic saline (HRS group), lactated ringer’s solution (LRS group), or crystalloid solution (LCRS group). Six rats from each ... more

Z.J. Wang; H.X. Wang; L. Li; L. Wang; H.H. Dou; Z.J. Wang; H.X. Wang; L. Li; L. Wang; H.H. Dou
12/02/2016
Administration, Oral; Animals; Bone marrow cells; Cell proliferation; Cells, Cultured; Guatemala; Humans; Lymphocytes; male; Mexico; Micronucleus tests; Mutagenicity Tests; Plant Extracts; Rats; Rubus; Sister chromatid exchange; Toxicity Tests, Subchronic

Rubus coriifolius Focke is a wild plant from the Rosaceae family. It grows in both Guatemala and Mexico. The polar extract of the aerial parts of this plant has antibacterial, anti-inflammatory, and anti-protozoal activities. These properties may explain the traditional use of this plant. In vivo and in vitro assays were used to assess the genotoxic and toxic effects of an ethanol extract of ... more

S. González-Hernández; D. González-Ramírez; M.I. Dávila-Rodríguez; A. Jimenez-Arellanez; M. Meckes-Fischer; S. Said-Fernández; E.I. Cortés-Gutiérrez
12/02/2016
Animals; Citalopram; Dementia, Vascular; Disease Models, Animal; Dopamine; Gene Expression Regulation; Hippocampus; Humans; Injections, Intraperitoneal; male; Neurons; Norepinephrine; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin; Treatment outcome

5-hydroxytryptamine receptor 1A (5-HT1AR) is closely associated with cognitive functions. Selective serotonin reuptake inhibitors (SSRIs) can protect individuals from brain damage following ischemia/hypoxia. To investigate the function of SSRIs in vascular dementia (VD), we established a rat model of VD, and observed the effect of SSRIs on the expression of 5-HT1AR mRNA and neurotransmitters. ... more

K. Guo; G. Yin; X.H. Zi; H.X. Zhu; Q. Pan
12/19/2016
Animals; Antimutagenic Agents; Antioxidants; Chromosome aberrations; Cyclophosphamide; Fruit; male; Malpighiaceae; Models, Animal; Plant Extracts; Rats; Rats, Wistar

Barbados cherry (BC) (Malpighia glabra Linnaeus) is a functional fruit that is consumed to prevent disease. It is used as an adjuvant in the treatment of several diseases, and acts as an antianemic, an appetite stimulant, a wound healer, an anti-inflammatory, a mineralizer, an antifungal, and an antioxidant agent. Several chemotherapeutic agents, such as cyclophosphamide, may result in ... more

E. Düsman; I.V. Almeida; L.T.D. Tonin; V.E.P. Vicentini
12/19/2016
Animals; Antimutagenic Agents; Cell line; Cell proliferation; DNA damage; Dose-Response Relationship, Drug; Plant Extracts; Rats; Vanillic Acid

The consumption of healthy and natural foods has increased over the last few years, primarily because these foods are rich in substances with biological properties of interest, such as exerting anticancer effects and decreasing oxidative stress in living tissues. These foods support adequate nutrition, maintain health, and improve quality of life. Vanillic acid (VA) is a phenolic compound used ... more

I.V. Almeida; F.M.L. Cavalcante; V.E.P. Vicentini
1/23/2017
Adipose tissue; Animals; Cell differentiation; Cell proliferation; Estradiol; Female; Pregnancy; Progesterone; Rats; Stem cells

Stem cell therapy faces many problems including poor survival rates and low viability. Enhancing the biological functions of stem cells improves efficacy of therapies. Estrogen, whose levels are elevated during pregnancy, affects the properties of bone marrow mesenchymal stem cells. Evidence suggests that adipose-derived stem cells (ADSCs), which are a type of adult mesenchymal stem cells, can ... more

J.N. Li; Y. Zhang; Y.F. Wang; J.Y. Chen
1/23/2017
Animals; Biomarkers; Drugs, Chinese Herbal; Endometrium; Estrous cycle; Female; Flavonoids; Immunohistochemistry; Rats

This study aimed to investigate the effect of icariin (ICA) on thin endometrium in a rat model. To this end, 6- to 8-week-old female Sprague Dawley rats (105) were randomly divided into 7 groups: untreated, vehicle-treated (lavage with NaCl), high-dose ICA (lavage with ICA at 200 mg∙kg∙day), medium-dose ICA (lavage ICA at 100 mg∙kg∙day), low-dose ICA (lavage with ICA at 50 mg∙kg∙day), sham ... more

A.W. Le; Z.H. Wang; X.Y. Dai; T.H. Xiao; R. Zhuo; B.Z. Zhang; Z.L. Xiao; X.J. Fang

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