Research Article

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06/17/2016
Congenital heart diseases; E3 ubiquitin ligase; Genetic variant; Mongolian; RNF41

This study aimed to explore the association between ring finger protein 41 (RNF41) c.-206 T > A variant and susceptibility to congenital heart disease (CHD) in the Chinese Mongolian population. The association between RNF41 gene c.-206 T > A polymorphism and CHD was examined in two independent case-control studies consisting of 219 CHD patients and 208 healthy ... more

Y. Zhang; S.Q. Jin; W.X. Li; G.Q. Gao; K. Zhang; J.L. Huang; Y. Zhang; S.Q. Jin; W.X. Li; G.Q. Gao; K. Zhang; J.L. Huang
10/19/2015
Arm-Gal4; Development; Drosophila melanogaster; Longevity; Parental inheritance; UAS-lacZ

The UAS-Gal4 ectopic expression system is a widely used and highly valued tool that allows specific gene expression in Drosophila melanogaster. Yeast transcription factor Gal4 can be directed using D. melanogaster transcriptional control elements, and is often assumed to have little effect on the organism. By evaluation of the consequences of maternal and ... more

F.A. Slade; B.E. Staveley
12/19/2016
Animals; Animals, Genetically Modified; Apoptosis Regulatory Proteins; Crosses, Genetic; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Humans; male; Membrane Proteins; Neurons; Proto-Oncogene Proteins c-bcl-2; Sequence Homology, Amino Acid; Transgenes

Lifeguard is an integral transmembrane protein that modulates FasL-mediated apoptosis by interfering with the activation of caspase 8. It is evolutionarily conserved, with homologues present in plants, nematodes, zebra fish, frog, chicken, mouse, monkey, and human. The Lifeguard homologue in Drosophila, CG3814, contains the Bax inhibitor-1 family motif of unknown function. Downregulation of ... more

P.G. M'Angale; B.E. Staveley
2/08/2017
Animals; Calcium; Calcium-Binding Proteins; Cation Transport Proteins; Drosophila; Drosophila melanogaster; Gene expression; Locomotion; Mitochondria; Mitochondrial Membrane Transport Proteins; Neurons; Proto-Oncogene Proteins c-bcl-2

The mitochondrial calcium uptake 1 (MICU1) is a regulatory subunit of the mitochondrial calcium uniporter that plays an important role in calcium sensing. It contains two EF-hand domains that are well conserved across diverse species from protozoa to plants and metazoans. The loss of MICU1 function in mammals is attributed to several neurological disorders that involve movement dysfunction. ... more

P.G. M'Angale; B.E. Staveley
07/31/2022
Chlorpyrifos; Climbing assay; Drosophila melanogaster; Feeding device; Negative geotaxis; PAST software

We developed a new and simple feeding device for Drosophila melanogaster. In addition, we tested three negative geotaxis methods (measuring the percentage of the flies able to climb 8 cm in 8 s, measuring the distance climbed in 3 s, and measuring the distance climbed in 8 s). The flies were exposed to chlorpyrifos (CPF) using the new feeding device. Our ... more

H.H. Abdulbaki; M.A. Al-Deeb
07/29/2021
Amyotrophic lateral sclerosis; Multiple sclerosis; Neurodegeneration; Neuroinflammation; Post-transcriptional regulation

Neurodegenerative diseases affect nerve cells, causing impairment in mobility and cognitive abilities, characteristics present in two highly relevant neuropathologies, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). The pathogenesis of these diseases, although distinct, share common neurodegenerative mechanisms. Several studies suggest that miRNAs ... more

J.C. Pereira; J.O. Costa; C.C.P. Costa; N.S. Lima; J.B.S. Barros; D.C.P. Bento; A.A.S. Reis; R.S. Santos
1/23/2017
Gene expression; Humans; Parkinson disease; Prion Proteins; REM Sleep Behavior Disorder; RNA, Messenger

Parkinson's disease (PD) is one of the most common neurodegenerative diseases and mainly manifests with decreasing numbers of dopaminergic neurons. Rapid eye movement (REM) sleep behavior disorder (RBD) has an incidence of 15-47% in all PD patients. Prion proteins (PrPs), which are expressed in both neurons and glial cells of the brain, are believed to be correlated with abnormal neurological ... more

W.J. Zhang; X.L. Shang; J. Peng; M.H. Zhou; W.J. Sun