Research Article

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05/09/2016
Apoptosis; Liver cancer; PTEN; Transfection

Liver cancer is a common malignant tumor associated with a short-survival period and high-mortality rate, and its prevalence in China is particularly high. This study aimed to investigate the effect of overexpressing the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene on liver cancer cell apoptosis and provide new insight into the treatment of this disease. ... more

M.F. Li; H. Guan; D.D. Zhang; M.F. Li; H. Guan; D.D. Zhang
06/10/2016
Apoptosis; Chondrocytes; CREB phosphorylation; Hypoxia; Mitochondrial dysfunction

Chondrocytes, which are embedded within the growth-plate or the intervertebral disc, are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signaling pathways underlying hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes. We first examined the apoptosis, caspase-3 activity, and apoptosis-associated ... more

Y.Y. Qiu; Y. Chen; T.H. Zeng; W.H. Guo; W.Y. Zhou; X.J. Yang; Y.Y. Qiu; Y. Chen; T.H. Zeng; W.H. Guo; W.Y. Zhou; X.J. Yang
06/03/2016
CXCR4; EGFR2; Endometriosis; MicroRNA; PTEN; VEGFA

We examined the aberrant microRNA (miRNA) expression profile responsible for the changes in angiogenesis observed in endometriotic lesions. This study revealed characteristic miRNA expression profiles associated with endometriosis in endometrial tissue and endometriotic lesions from the same patient, and their correlation with the most important angiogenic and fibrinolytic factors. miRNA ... more

R.Q. Yang; H. Teng; X.H. Xu; S.Y. Liu; Y.H. Wang; F.J. Guo; X.J. Liu; R.Q. Yang; H. Teng; X.H. Xu; S.Y. Liu; Y.H. Wang; F.J. Guo; X.J. Liu
07/29/2016
Acquired drug-resistance; Pancreatic cancer; Pemetrexed; PI3K/Akt signal transduction pathway; PIK3CA; PTEN

The aim of this study was to investigate the expression of PTEN and PIK3CA in the pemetrexed-resistant human pancreatic cancer cell line Patu8988, and to evaluate their effects on the biological behavior of pancreatic cancer cells. PTEN and PIK3CA gene and protein expressions were detected by reverse transcriptase polymerase chain reaction (RT-PCR) and western blot, respectively, in a ... more

X. Shi; H.T. Gu; S.B. Lin; Y. Zhang; J. Yang; C.J. Qian; X. Shi; H.T. Gu; S.B. Lin; Y. Zhang; J. Yang; C.J. Qian
06/17/2016
Cardiomyocytes; Hypoxia; Sphingomyelinases; Ursodeoxycholic acid

Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing ceramide, and inhibition of SMases activity can promote cell survival. We hypothesized that ... more

N.I. Hanafi; A.S. Mohamed; M. Noor; A.Hamid Hasani; R. Siran; N.J. Osman; A. Rahim; S.H.Sheikh Abd Kadir; N.I. Hanafi; A.S. Mohamed; M. Noor; A.Hamid Hasani; R. Siran; N.J. Osman; A. Rahim; S.H.Sheikh Abd Kadir
04/26/2016
Antimutagenesis; Apoptosis; Campomanesia adamantium; Micronucleus; Mutagenesis

Campomanesia adamantium (Cambess.) O. Berg. is originally from Brazil. Its leaves and fruits have medicinal properties such as anti-inflammatory, antidiarrheal and antiseptic properties. However, the mutagenic potential of this species has been reported in few studies. This study describes the mutagenic/antimutagenic, splenic phagocytic, and apoptotic activities of C. ... more

M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira; M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira; M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira
04/25/2016
Apoptosis; Ndfipl; Parkinson’s disease; Ubiquitination

The aim of the current study was to examine the protective effects and mechanisms of Ndfipl on neurocytes in an experimental in vitro Parkinson’s disease model induced by MPP+. The cell model was developed with dominant negative expression and suppressed expression of Ndfipl by means of transient transfection of Ndfipl-dominant negative and -inhibitory vectors. In total, four ... more

L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan; L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan; L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan
04/07/2016
Apoptosis; Autophagy; Beclin-1; Colorectal cancer; MicroRNA-30a; Prognosis

We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance of Beclin-1 in CRC, while the weak expression of Beclin-1 in ... more

L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang; L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang; L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang
04/04/2016
Apoptosis; Gastric cancer; miR-451; MMP-2; Proliferation; Propofol

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 ... more

Z. Peng; Y. Zhang; Z. Peng; Y. Zhang; Z. Peng; Y. Zhang
04/04/2016
Apoptosis; Colorectal cancer; Invasion; MiR-874; Prognosis; Proliferation
X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi

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