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Toll-like receptors (TLRs) can specifically identify pathogen-associated molecular patterns (PAMPs) by recognizing structural patterns in diverse microbial molecules, and can provide an effective defense against multiple microbial infectious. A variety of TLRs can be expressed on the surface of liver parenchymal as well as nonparenchymal cells. Kupffer cells are a type of hepatic ... more

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Crosstalk; Hepatitis B virus; Hepatocellular carcinoma; Network; Pathway

This study aims to identify significant pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) based on the pathway network strategy. We proposed a pathway network where a protein-protein interaction (PPI) network was integrated with the crosstalk of pathways. Pathway data were first obtained from background PPI network, Reactome pathway database, and common genes ... more

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Hepatocellular carcinoma; mt-tRNA; mutations; Polymorphisms

Mitochondrial DNA mutations have been shown to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). In particular, genes encoding mitochondrial tRNA (mt-tRNA) are hotspots for pathogenic mutations associated with HCC. Recently, an increasing number of studies have reported the involvement of such mutations in this disease. As a result, several mt-tRNA mutations ... more

G. Li; Y.X. Duan; X.B. Zhang; F. Wu; G. Li; Y.X. Duan; X.B. Zhang; F. Wu
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Hepatocellular carcinoma; Meta-analysis; Methylation; Pathogenesis; RUNX3

The aim of this study was to elucidate the role of RUNX3 promoter methylation in the pathogenesis of hepatocellular carcinoma (HCC) among Asians. For this purpose, we performed a comprehensive search of Chinese and English language scientific literature databases using stringent selection criteria; ultimately, we identified relevant studies that specifically assessed the ... more

W. Lu; Y. Liu; L.L. Liu; P.H. Zhuang; W. Lu; Y. Liu; L.L. Liu; P.H. Zhuang
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Cyclooxygenase-2 (COX-2) influences carcinogenesis through regulation of angiogenesis, apoptosis, cytokine expression, and immune response suppression. It has been well established that COX-2 is overexpressed in a variety of human cancers, such as hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the association between COX-2 polymorphisms and prognosis of HCC. We ... more

R. Liang; X.X. Yan; Y. Lin; Q. Li; C.L. Yuan; Z.H. Liu; Y.Q. Li; R. Liang; X.X. Yan; Y. Lin; Q. Li; C.L. Yuan; Z.H. Liu; Y.Q. Li
04/28/2016
Nuclear factor kappa B; Repeated implantation failure; Single nucleotide polymorphism; SNP

Despite more than a century of intensive study, the mechanisms of successful pregnancy remain unclear. Recent research suggests that NF-κB (nuclear factor kappa B) plays an important role in embryo implantation. In the current study, we aimed to identify SNPs that contribute to genetic susceptibility for recurrent implantation failure (RIF). Thus, we examined the potential associations ... more

L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao
04/28/2016
Case-control study; Gout; Single nucleotide polymorphism; WDR1

Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this disease in the Han Chinese population. We genotyped ... more

L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin
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Colorectal cancer; High-resolution melting; Mismatch repair gene; Single nucleotide polymorphism

Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese patients. Therefore, the present study aimed to ... more

H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin; H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin; H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin
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Acute rejection; Cytokines; Liver transplantation; Single nucleotide polymorphism

Acute rejection (AR) recurrence after liver transplantation (LT) is one of the major complications that leads to chronic graft dysfunction. It has been reported that the polymorphisms in some cytokine genes are associated with human liver allograft rejection. This study mainly investigated the associations between polymorphisms in the genes encoding interleukin-10 (IL10), ... more

X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang; X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang; X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang
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CD4 T cell; CD8 T cell; HIV; Single nucleotide polymorphism

Toll-like receptors (TLRs) are essential elements of the innate immune response to different infections including the infection with human immunodeficiency virus (HIV). Single nucleotide polymorphisms (SNPs) in TLRs such as TLR4 1063A/G and 1363C/T have been found to be associated with changes in CD4 count, viral load (VL), and disease progression during HIV infection. However, ... more

E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri; E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri; E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri

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