Research Article

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We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People’s Hospital. For SNP genotyping, we used the Assay Designer 3.1 to design the ... more

M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei; M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei; M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei
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Classic Kaposi sarcoma is a type of vascular proliferative inflammatory disease. Previous studies have reported significant associations between microRNAs expression and the development of classic Kaposi sarcoma. Here, we conducted a case-control study to investigate the association between miR-146a and miR-149 genetic polymorphisms and ... more

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ERCC1; ERCC2; Gastric cancer; Polymorphism; Treatment outcome

We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platinum-based chemotherapy were recruited from the ... more

D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin
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Gastric cancer; MicroRNA; Polymorphism; Review

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent. Sequence ... more

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06/17/2016
ERCC5; Gastric cancer; Polymorphism

We investigate the role of ERCC5 gene polymorphisms (rs17655 and rs751402) in the development of gastric cancer in a Chinese population. A total of 142 gastric cancer patients whose diagnoses were confirmed by pathology, and 274 control subjects were recruited from Tangshan Gongren Hospital between March 2013 and March 2015. Genotyping of ERCC5 rs17655 and rs751402 ... more

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06/10/2016
Chinese population; Gastric cancer; Polymorphism; XPG

We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a total of 177 patients with gastric cancer and 237 ... more

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06/10/2016
ERCC5; Gastric cancer; Polymorphism; rs2094258; rs751402

We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population. This investigation included 184 patients with pathologically diagnosed gastric cancer and 206 healthy subjects recruited between October 2012 and December 2014. The genotyping ... more

J.J. Lu; H.Q. Zhang; P. Mai; X. Ma; X. Chen; Y.X. Yang; L.P. Zhang; J.J. Lu; H.Q. Zhang; P. Mai; X. Ma; X. Chen; Y.X. Yang; L.P. Zhang
06/03/2016
Gastric cancer; Interleukin-17; Polymorphism; rs2275913

The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People’s Hospital between March 2013 and March 2015. The IL-17 rs2275913 gene polymorphism was identified by ... more

B.L. Xu; Y.T. Li; S.X. Dong; J. Qi; H.M. Feng; L. Zi; D.Y. Yang; B.L. Xu; Y.T. Li; S.X. Dong; J. Qi; H.M. Feng; L. Zi; D.Y. Yang
08/31/2012
Cancer susceptibility; Gender; miR-146a; Polymorphism; Smoking

Evidence has shown that miR-146a is involved in carcinogenesis, and a common G/C variant (rs2910164) in the pre-miR-146a gene has been associated with various types of cancer. We summarized the data from 22 published case-control studies on the association between rs2910164 and cancer risk and performed subgroup analyses by ethnicity, gender and smoking status. We found a ... more

A.X. Wang; B. Xu; N. Tong; S.Q. Chen; Y. Yang; X.W. Zhang; H. Jiang; N. Liu; J. Liu; X.N. Hu; G.Z. Sha; M. Chen
12/18/2014
Biochemical recurrence; miR-146a; Polymorphism; Prostate cancer

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were ... more

M. Chen; Z.Y. Zhou; J.G. Chen; N. Tong; S.Q. Chen; Y. Yang; X.W. Zhang; H. Jiang; N. Liu; J. Liu; G.Z. Sha; W.D. Zhu; L.X. Hua; Z.J. Wang; B. Xu

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