Research Article

Related GMR Articles

05/09/2016
-1082A/G; -819T/; Acute pancreatitis; Interleukin-10; Polymorphism

Recent studies have suggested that chemokines contribute to the initiation and development of acute pancreatitis. We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, in order to provide data for screening high-risk Chinese individuals. In total, 182 patients with confirmed cases of ... more

B.Z. Jiang; L. Tang; H. Xue; D.P. Liu; B.Z. Jiang; L. Tang; H. Xue; D.P. Liu
05/09/2016
Gestational diabetes mellitus; Polymorphism; Scientific production

Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the associations between genetic polymorphisms and gestational diabetes ... more

J.S. Gomes; L.B. Minasi; A.D. da Cruz; F.M. Rodrigues; J.S. Gomes; L.B. Minasi; A.D. da Cruz; F.M. Rodrigues
05/09/2016
Diabetic nephropathy; IL-10 -1082G/A; IL-10 -592A/C; IL-10 -819T/C; Polymorphism

In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polymerase chain reaction-restriction ... more

D.H. Ma; Q.Y. Xu; Y. Liu; Q.Q. Zhai; M.H. Guo; D.H. Ma; Q.Y. Xu; Y. Liu; Q.Q. Zhai; M.H. Guo
09/08/2015
Glioma; Single-nucleotide polymorphism; susceptibility; X-ray cross-complementing group 3

The susceptibility to glioma is not well understood. It has been suggested that the X-ray cross complementing group 3 (XRCC3) gene influences the capacity to repair DNA damage, leading to increased glioma susceptibility. In this study, we evaluated the relationship between XRCC3 mutations and glioma risk. Genotypes were assessed in 389 Chinese glioma patients and 358 healthy controls. ... more

J.Y. Huang; J.F. Yang; Q. Qu; J. Qu; F. Liu; F.E. Liu; T. Xiong; S.H. Lu
07/13/2015
hsa-miR-146a; Intracranial aneurysm; Polymorphism; susceptibility

Vascular inflammation has been shown to be involved in the pathogenesis of intracranial aneurysms (IA). MiRNAs are key molecules that participate in the regulation of many important biological processes including inflammation. Studies on the hsa-miR-146a rs2910164 polymorphism and its association with different inflammatory related diseases have engendered inconsistent ... more

X.T. Sima; J.G. Xu; J. Li; C. You
12/29/2015
Association study; Polymorphism; RAGE; susceptibility; Ulcerative colitis

Ulcerative colitis (UC) is an immune-related disease with genetic predisposition. The aim of this study was to investigate the association of three polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with UC risk in a Chinese population. This case-control study involved 72 UC patients and 479 age- and gender-matched healthy controls. Genotyping was ... more

Z.T. Wang; L.Y. Wang; L. Wang; S. Cheng; R. Fan; J. Zhou; J. Zhong
12/17/2015
Meta-analysis; NAT2; Pancreatic cancer; Polymorphism; susceptibility

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to assess this relationship ... more

J.X. Liang; W. Gao; Y. Liang; X.M. Zhou
12/03/2015
Autoimmune disease; Human leukocyte antigen-G; Indel polymorphism; Meta-analysis; susceptibility

Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and ... more

S.K. Kim; K.H. Jeong; I.J. Kang; J.H. Chung; M.K. Shin; M.H. Lee

Pages