Research Article

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03/28/2016
Genetic polymorphism; Hypertension; MTHFR; Risk factors

The association of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and essential hypertension has been reported but with controversial results in diverse populations in Asia and Europe, thereby suggesting a dependency on ethnicity. The aim of this study was to investigate the association between the MTHFR C677T polymorphism and essential ... more

S.M. Ghogomu; N.E. Ngolle; R.N. Mouliom; B.F. Asa; S.M. Ghogomu; N.E. Ngolle; R.N. Mouliom; B.F. Asa; S.M. Ghogomu; N.E. Ngolle; R.N. Mouliom; B.F. Asa
07/14/2016
Hypertension; Left ventricular hypertrophy; Receptor for advanced glycation end-products

Soluble receptor for advanced glycation end-products (sRAGE) acts as a decoy to prevent interaction between RAGE and its pro-inflammatory ligands. sRAGE levels have been found to decrease in chronic inflammatory diseases, including hypertension. However, few data have been reported concerning the association between serum sRAGE levels and hypertensive left ventricular hypertrophy (LVH). ... more

Q. Liu; H.B. Chen; M. Luo; H. Zheng; Q. Liu; H.B. Chen; M. Luo; H. Zheng
06/24/2016
Ethnicity; Hazara Division; mtDNA; Pakistan; Phylogenetics

Mitochondrial DNA (mtDNA) is an important tool used to explore ethnogenetics and the evolutionary history of human populations. In this study, hypervariable segment I (HVSI) from mtDNA was analyzed to establish the genetic lineage of the Hazarewal populations residing in the Mansehra and Abbottabad districts of Northern Pakistan. HVSI was extracted from genetic specimens obtained from 225 ... more

N. Akbar; H. Ahmad; M.S. Nadeem; B.E. Hemphill; K. Muhammad; W. Ahmad; M. Ilyas; N. Akbar; H. Ahmad; M.S. Nadeem; B.E. Hemphill; K. Muhammad; W. Ahmad; M. Ilyas
05/06/2016
DNA extraction; mtDNA; Parchment; PCR; species identification

Historical parchments in the form of documents, manuscripts, books, or letters, make up a large portion of cultural heritage collections. Their priceless historical value is associated with not only their content, but also the information hidden in the DNA deposited on them. Analyses of ancient DNA (aDNA) retrieved from parchments can be used in various investigations, including, but not ... more

T. Lech; T. Lech
04/26/2016
Calendula; Colchicine; Flowering yield; Molecular diversity; Mutation; SRAP

Six different colchicine concentrations: 0, 400, 800, 1200, 1600, and 2000 ppm, in combination with four soaking time treatments (1, 2, 3, and 4 h), were selected to assess the effects on germination, vegetative growth, and flower yield components in calendula plants. The molecular diversity among the treatments was assessed using ten SRAP marker combinations. Seed soaking in colchicine ... more

Y.I. El-Nashar; M.H. Ammar; Y.I. El-Nashar; M.H. Ammar; Y.I. El-Nashar; M.H. Ammar
07/14/2016
Capture sequencing of second-generation exons; Duchenne muscular dystrophy; Gene; Mutation; Pedigree study

The aim of this study was to identify the mutation site and phenotype of the Duchenne muscular dystrophy (DMD) gene in a DMD family. The DMD gene is by far the largest known gene in humans. Up to 34% of the point mutations reported to date affect splice sites of the DMD gene. However, no hotspot mutation has been reported. Capture sequencing of second-generation ... more

Y.B. Zhu; J.H. Gan; J.W. Luo; X.Y. Zheng; S.C. Wei; D. Hu; Y.B. Zhu; J.H. Gan; J.W. Luo; X.Y. Zheng; S.C. Wei; D. Hu
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Mutation; Retinitis pigmentosa; RP2; RPGR; X-linked

Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous disease causing progressive degeneration of retinal photoreceptor cells. X-linked RP (XLRP), in which photoreceptor degeneration begins in early childhood and complete blindness often occurs by the fourth decade of life, constitutes the most severe form of this disease. Two genes commonly associated with XLRP have ... more

M.F. Haddad; O.F. Khabour; K.A.Y. Abuzaideh; W. Shihadeh; M.F. Haddad; O.F. Khabour; K.A.Y. Abuzaideh; W. Shihadeh
05/06/2016
Diethyl sulfate; Enzyme activity; Gas-exchange; Mutation; Sodium azide

Chemical mutagenesis is an efficient tool used in mutation-breeding programs to improve the vital characters of the floricultural crops. This study aimed to estimate the effects of different concentrations of two chemical mutagens; sodium azide (SA) and diethyl sulfate (DES). The vegetative growth and flowering characteristics in two generations (M1 and M2) of ... more

Y.I. El-Nashar; A.A. Asrar; Y.I. El-Nashar; A.A. Asrar