Research Article

Related GMR Articles

05/13/2016
Gastric cancer; miR-146a; miR-149; miR-196a2; Polymorphism

Here, we performed a case-control study to investigate the role of miR-146a, miR-149, and miR-196a2 polymorphisms in the development of gastric cancer using a hospital-based case-control design. A total of 186 gastric cancer patients and 186 control subjects were enrolled from Ren Ji Hospital between January 2012 and October 2014. MicroRNAs miR-146a, miR-149, and miR-196a2 were genotyped ... more

J.Y. Gu; L. Tu; J.Y. Gu; L. Tu
05/13/2016
Coronary artery disease; Matrix metalloproteinase-9; Polymorphism

We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with control subjects, patients with coronary artery disease had ... more

L.M. Qin; G.M. Qin; X.H. Shi; A.L. Wang; H. Zuo; L.M. Qin; G.M. Qin; X.H. Shi; A.L. Wang; H. Zuo
05/09/2016
-1082A/G; -819T/; Acute pancreatitis; Interleukin-10; Polymorphism

Recent studies have suggested that chemokines contribute to the initiation and development of acute pancreatitis. We evaluated the relationship between IL-10 gene polymorphisms (-1082A/G and -819T/C) and development of acute pancreatitis in the Chinese population, in order to provide data for screening high-risk Chinese individuals. In total, 182 patients with confirmed cases of ... more

B.Z. Jiang; L. Tang; H. Xue; D.P. Liu; B.Z. Jiang; L. Tang; H. Xue; D.P. Liu
05/09/2016
Gestational diabetes mellitus; Polymorphism; Scientific production

Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the associations between genetic polymorphisms and gestational diabetes ... more

J.S. Gomes; L.B. Minasi; A.D. da Cruz; F.M. Rodrigues; J.S. Gomes; L.B. Minasi; A.D. da Cruz; F.M. Rodrigues
05/09/2016
Diabetic nephropathy; IL-10 -1082G/A; IL-10 -592A/C; IL-10 -819T/C; Polymorphism

In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polymerase chain reaction-restriction ... more

D.H. Ma; Q.Y. Xu; Y. Liu; Q.Q. Zhai; M.H. Guo; D.H. Ma; Q.Y. Xu; Y. Liu; Q.Q. Zhai; M.H. Guo
09/22/2015
Chemotherapy; ERCC1; ERCC2; Osteosarcoma; Overall survival; Single nucleotide polymorphism

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess ... more

Q. Zhang; L.Y. Lv; B.J. Li; J. Zhang; F. Wei
08/21/2015
Clinical outcome; ERCC1; ERCC2; Osteosarcoma; Polymorphism

We aimed to evaluate the influence of four SNPs in ERCC1 and ERCC2 on the response to cisplatin-based treatment and on clinical outcome in patients with osteosarcoma. We identified 186 patients with osteosarcoma diagnosed between April 2009 and April 2011 who were eligible for inclusion in our study. Genotyping of ERCC1 rs11615, rs3212986, and rs2298881; and ... more

Z.H. Cao; H.P. Yin; N. Jiang; B. Yu
12/21/2015
Clinical outcome; ERCC1; ERCC2; Gastric cancer; Polymorphism

We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+ ... more

W.H. Yu; Y.X. Wang; J.Q. Guo; Y.L. Wang; J.S. Zheng; K.X. Zhu
12/17/2015
ERCC1; ERCC2; Gastric cancer; Overall survival; Polymorphism; Response to chemotherapy

We investigate whether three common polymorphisms in ERCC1 and ERCC2 are predictor factors for the chemotherapy response, as well as the clinic outcome of patients with gastric cancer. Between May 2011 and May 2013, 263 patients with gastric cancer who were newly diagnosed by histopathology were enrolled in our study. Genotyping of the ERCC1 rs11615 and rs3212986, ... more

G. Zhong; H.K. Li; T. Shan; N. Zhang

Pages