Research Article

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06/20/2016
Congenital choledochal cysts; Protein expression; Survivin

The aim of the current study was to investigate survivin expression in congenital choledochal cysts (CCCs), and its associations with clinical parameters of CCCs. In total, 121 children with CCCs were included in this study as the case group, and their cysts were staged according to the Todani classification system. Additionally, 49 normal gallbladder specimens from healthy children were ... more

Z.G. Wu; G.X. Li; B. Wang; Z.M. Chen; Q. Feng; Z.G. Wu; G.X. Li; B. Wang; Z.M. Chen; Q. Feng
05/06/2016
Cancer; Equilibrative nucleoside transporter proteins; Nucleoside analog; Nucleotide transporters; Ribonucleotide reductase subunit M1

We investigated the variability in the expression of human equilibrative nucleoside transporter 1 (hENT1) and ribonucleotide reductase subunit M1 (RRM1) in non-Hodgkin lymphoma cell lines. hENT1 and RRM1 mRNA expression levels in natural killer (NK) cells and seven non-Hodgkin lymphoma cell lines (YTS, SNK-6, Jeko-1, ly-1, Raji, Karpas, and Jurket) were studied using reverse- ... more

H.B. Zhao; X.F. Zhang; F. Shi; M.Z. Zhang; W.L. Xue; H.B. Zhao; X.F. Zhang; F. Shi; M.Z. Zhang; W.L. Xue
04/27/2016
Chronic obstructive pulmonary disease; Epoxide hydrolase 1; Meta-analysis; Nonsynonymous single-nucleotide polymorphisms; Variable threshold

Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. In recent years, as one of the most widely studied genes ... more

L. An; H. Xia; P. Zhou; L. Hua; L. An; H. Xia; P. Zhou; L. Hua; L. An; H. Xia; P. Zhou; L. Hua
04/26/2016
A1298C; C677T; Male infertility; Meta-analysis; MTHFR; Polymorphisms

Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of PubMed, EMBASE, the Cochrane Library, the Web of Science ... more

Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu; Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu; Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu
04/25/2016
Meta-analysis; Methylation; Promoter; RASSF1A; Renal cell cancer

Epigenetic inactivation of Ras-associated domain family 1A (RASSF1A) by hyper-methylation of its promoter region has been identified in various cancers. However, the role of RASSF1A in renal cancer has neither been thoroughly investigated nor reviewed. In this study, we reviewed and performed a meta-analysis of 13 published studies reporting correlations between ... more

Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen; Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen; Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen
04/07/2016
A1298C; C677T; Lung cancer; Meta-analysis; MTHFR; Polymorphisms

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource ... more

Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu
04/04/2016
135G/C polymorphism; Acute myeloid leukemia; Meta-analysis; RAD51

Numerous studies have evaluated the association between the 135G/C polymorphism in the RAD51 gene and risk of acute myeloid leukemia (AML), but the results have been inconsistent. The aim of this study is to precisely examine the association between the 135G/C polymorphism in the RAD51 gene and AML risk through a meta-analysis. PubMed, Google Scholar, and Web of Science databases were ... more

L. Wu; Z.G. Long; Z.S. Dai; L. Wu; Z.G. Long; Z.S. Dai; L. Wu; Z.G. Long; Z.S. Dai
04/04/2016
Breast cancer; Meta-analysis; MicroRNA-10b; Prognostic factor

Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-10b involvement in human breast cancer and analyze the predicting role of miR-10b for survival. We searched, Embase, and Wanfang databases to identify studies on the prognostic role of miR-10b ... more

N. Wang; P. Chen; L.P. Huang; T.Z. Wang; N. Wang; P. Chen; L.P. Huang; T.Z. Wang; N. Wang; P. Chen; L.P. Huang; T.Z. Wang
04/04/2016
Coffee intake; CYP1A2; Ethnicity; Meta-analysis; rs762551 SNP

The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial. We conducted a meta-analysis to clarify this potential association. Twelve studies were selected from articles retrieved from the and Google Scholar databases, and the data were analyzed to determine the ... more

S. Denden; B. Bouden; H. Khelil; J. Ben Chibani; M.H. Hamdaoui; S. Denden; B. Bouden; H. Khelil; J. Ben Chibani; M.H. Hamdaoui; S. Denden; B. Bouden; H. Khelil; J. Ben Chibani; M.H. Hamdaoui
07/14/2016
Meta-analysis; Monoamine oxidase B; Parkinson’s disease; Polymorphism

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as ... more

J.J. Liu; W. Wang; M. Meng; C.S. Liang; J.W. Zhang

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