Research Article

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04/28/2016
Chemotherapy; GSTM1; GSTP1 polymorphism; GSTT1; NSCLC

The aim of this study was to evaluate the association of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms with the chemotherapy response and overall survival of advanced NSCLC. Two hundred and sixty-two patients with histologically confirmed advanced NSCLC (inoperable TNM stages IIIA, IIIB, and IV) were enrolled to this hospital-based ... more

H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei; H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei; H.L. Xiao; Z.T. Yang; F. Han; H.X. Wei
05/09/2016
Gestational diabetes mellitus; Polymorphism; Scientific production

Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the associations between genetic polymorphisms and gestational diabetes ... more

J.S. Gomes; L.B. Minasi; A.D. da Cruz; F.M. Rodrigues; J.S. Gomes; L.B. Minasi; A.D. da Cruz; F.M. Rodrigues
05/25/2016
CYP1A1; Estrogen receptor β; GSTM1; GSTT1; p53; Progesterone receptor

In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response ... more

K.S.F. Silva; K.K.V.O. Moura; K.S.F. Silva; K.K.V.O. Moura
01/29/2016
Colorectal carcinoma; GSTM1; Polymorphism

The enzyme glutathione S-transferase Mu 1 (GSTM1) is encoded by the GSTM1 gene. Polymorphisms in GSTM1 affect the detoxifying function of the enzyme variants. This forms the basis of the debate about the impact of the GSTM1 null/present genotype on colorectal carcinoma risk. We tested the potential influence of GSTM1 polymorphisms on the development of ... more

M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz
04/28/2016
16S rDNA; Pathogenicity island; Polymerase chain reaction; Polymorphism

Chromobacterium violaceum is a free-living Gram-negative bacillus usually found in the water and soil in tropical regions, which causes infections in humans. Chromobacteriosis is characterized by rapid dissemination and high mortality. The aim of this study was to detect the genetic variability among C. violaceum type strain ATCC 12472, and seven isolates from the ... more

A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa; A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa; A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa
04/28/2016
Coronary artery disease; IL-10-1082A/G; Polymorphism

We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and December 2014. Subjects were genotyped for IL-10 ... more

K. Liang; S.R. Dong; H. Peng; K. Liang; S.R. Dong; H. Peng; K. Liang; S.R. Dong; H. Peng
04/26/2016
ERCC1; ERCC2; Gastric cancer; Polymorphism; Treatment outcome

We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platinum-based chemotherapy were recruited from the ... more

D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin
04/26/2016
Bladder cancer; CYP1A2; Polymorphism; Risk

To date, no study has investigated the association between CYP1A2-163C/A polymorphism and bladder cancer risk in a Chinese population. Here, we extracted genomic DNA from peripheral white blood cells, and differentiated CYP1A2 alleles by polymerase chain reaction-based restriction fragment length polymorphism methods. Differences in genotype frequencies between the cases ... more

Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu
04/28/2016
Esophageal cancer; Genetic variant; Polymorphism; Tumor necrosis factor-alpha
H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu
07/14/2016
Meta-analysis; Monoamine oxidase B; Parkinson’s disease; Polymorphism

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as ... more

J.J. Liu; W. Wang; M. Meng; C.S. Liang; J.W. Zhang

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