Research Article

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Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures distinguishing ICM/NICM from control samples. Furthermore, we ... more

X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han; X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han; X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han
05/05/2009
Codon 72 polymorphism; Endometriosis; p53 gene

We examined the frequency of p53 codon 72 polymorphism in 38 patients with endometriosis whose diagnosis was confirmed using videolaparoscopy. Half of the women were infertile. There were no significant differences in the genotype (P = 0.0927) or allele frequencies (P = 0.1430) for p53 Arg72Pro polymorphism between the two groups. We found a significant association between the heterozygous and ... more

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07/06/2011
Endometriosis; PCR; Progesterone receptor; PROGINS

We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and ... more

I.R. Costa; R.C.P.C. Silva; A.B. Frare; C.T.X. Silva; B.M. Bordin; S.R. Souza; C.L.Ribeiro Júnior; K.K.V.O. Moura
03/22/2011
Endometriosis; Estrogen receptor; Polymorphism and Infertility

We examined the frequency of RsaI polymorphism of the ERβgene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymor­phisms of the ERβgene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ... more

R.C.P.C. Silva; I.R. Costa; B.M. Bordin; C.T.X. Silva; S.R. Souza; C.L.R. Júnior; A.B. Frare; K.K.V.O. Moura
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DNA repair; Endometriosis; Polymorphism; XRCC3 Thr/Thr

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by PCR-RFLP assays in 52 patients with endometriosis and 101 age- ... more

R. Attar; C. Cacina; S. Sozen; E. Attar; B. Agachan
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Endometriosis; GSTM1; GSTT1; Infertility

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of ... more

A.B. Frare; A.M. Barbosa; I.R. Costa; S.R. Souza; R.C.P.C. Silva; B.M. Bordin; C.L.Ribeiro Júnior; K.K.V.O. Moura
04/02/2013
Endometriosis; Meta-analysis; Polymorphism; VEGF

Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that VEGF plays a role in the ... more

Y.Z. Li; L.J. Wang; X. Li; S.L. Li; J.L. Wang; Z.H. Wu; L. Gong; X.D. Zhang
05/15/2012
Codon 72; Endometriosis; Mexican population; Polymorphism; TP53 gene

The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 Mexican women with endometriosis. The observed genotype ... more

M.P. Gallegos-Arreola; L.E. Figuera-Villanueva; A.M. Puebla-Pérez; H. Montoya-Fuentes; A.E. Suarez-Rincon; G.M. Zúñiga-González
09/05/2014
Endometriosis; Epidermal growth factor; Polymorphism

The aim of this study was to verify the association between the epidermal growth factor (EGF) +61 G/A polymorphism and the susceptibility to endometriosis using a case-control design study. The control group included fertile women without endometriosis and the case group included endometriosis patients. Polymerase chain reaction-restriction fragment length polymorphism analysis ... more

C.B.N. Oliveira; P. Falagan-Lotsch; M.G. Souza; R.P. Santos; F. Encinas; H. Teles; R.B. Lasmar; L.B. Duarte; J.M. Granjeiro; I.A. Penna
08/26/2014
Cell cycle; Endometriosis; Gene polymorphism; p53; TP53

We evaluated the association between TP53 gene polymorphisms and endometriosis in Brazilian women. Genomic DNA was extracted from swabs of buccal cells collected from hospital patients. TP53 gene polymorphisms were investigated at three codons: TP53*11 Glu/Gln or Lys (GAG->CAG or AAG), TP53*72 Arg/Pro (CCG->CCC), and TP53*248 Arg/Thr (CGG ... more

C.M. Camargo-Kosugi; P. D’Amora; J.P.F.O. Kleine; C.V. Carvalho; H. Sato; E. Schor; I.D.C.G. Silva

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