Research Article

Related GMR Articles

04/28/2016
Esophageal cancer; Genetic variant; Polymorphism; Tumor necrosis factor-alpha
H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu
06/24/2016
EC-9706 cells; EGFR; ERCC1; Esophageal cancer; p53; SNX-2112

SNX-2112 is a potential molecular targeted therapeutic drug against esophageal cancer (EC). However, its exact mechanism of action remains to be explained. The aim of this study was to investigate the effect of SNX-2112 on excision repair cross- complementing 1 (ERCC1), epidermal growth factor receptor (EGFR), and p53, to elucidate the mechanism of action of SNX-2112 on EC. Fresh tumor ... more

C.Y. Li; Y.J. Ren; Y.D. Li; C.Y. Li; Y.J. Ren; Y.D. Li
06/20/2016
Basigin gene; Esophageal cancer; miR-483-5p; Polymorphism

The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer patients and 636 cancer-free age- and gender-matched ... more

H.Y. Li; Y.C. Liu; Y.H. Bai; M. Sun; L. Wang; X.B. Zhang; B. Cai; H.Y. Li; Y.C. Liu; Y.H. Bai; M. Sun; L. Wang; X.B. Zhang; B. Cai
12/02/2015
Gemcitabine; Pancreatic cancer; Radiosensitization; Radiotherapy

The aim of this study was to evaluate the radiosensitizing effects of gemcitabine towards human pancreatic cancer xenografts. A human pancreatic cancer xenograft model was established in nude mice, 36 of which were randomly divided into 6 treatment groups. Tumors were measured every 2 days, and the tumor volumes, growth delays, and inhibition rates were compared to evaluate the ... more

Z.T. Shen; X.H. Wu; L. Wang; B. Li; X.X. Zhu
10/27/2015
Head and neck cancer; MTHFR; Radiotherapy

The C677T and A1298C polymorphisms in methylene­tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, such as nucleotide synthesis and biomolecule methylation, it seems plausible that patients with head and neck squamous cell carcinoma (HNSCC) may respond ... more

Q.S. Anders; E. Stur; L.P. Agostini; F.M. Garcia; R.S. Reis; J.A. Santos; S.O. Mendes; L.L. Maia; G.T. Peterle; V. Stange; M.B. Carvalho; E.H. Tajara; M. Santos; A.M.A. Silva-Conforti; I.D. Louro
10/16/2015
Head and neck cancer; Prognostic outcome; Radiotherapy; Repair genes

The aims of this study were to analyze the polymorphisms XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPC Lys939Gln, ERCC1 Asn118Asn, and RAD51 -98G>C and to verify their influence on radiotherapy response and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). Peripheral blood DNA was extracted from 311 patients and analyzed by PCR-RFLP. Our results showed ... more

E. Stur; L.P. Agostini; F.M. Garcia; G.T. Peterle; L.L. Maia; S.O. Mendes; Q.S. Anders; R.S. Reis; J.A. Santos; D.P. Ventorim; M.B. Carvalho; E.H. Tajara; M. Santos; F. Paula; A.M.A. Silva-Conforti; I.D. Louro
10/17/2016
Clinically negative node; Meta-analysis; Radical neck dissection; Radiotherapy; Supraglottic carcinoma

The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were “supraglottic carcinoma”, “cervical lymph nodes negative/cN0”, “radical neck dissection”, and “radiotherapy”. The databases included the Chinese biomedical literature database, Medline, Cochrane ... more

Y.H. Liu; Z.W. Du