Research Article

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06/17/2016
Cardiomyocytes; Hypoxia; Sphingomyelinases; Ursodeoxycholic acid

Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing ceramide, and inhibition of SMases activity can promote cell survival. We hypothesized that ... more

N.I. Hanafi; A.S. Mohamed; M. Noor; A.Hamid Hasani; R. Siran; N.J. Osman; A. Rahim; S.H.Sheikh Abd Kadir; N.I. Hanafi; A.S. Mohamed; M. Noor; A.Hamid Hasani; R. Siran; N.J. Osman; A. Rahim; S.H.Sheikh Abd Kadir
05/12/2016
Apoptosis; Brain damage; Hypoxia; miR-152; PTEN

Brain damage caused by perinatal asphyxia is dangerous for neonatal infants, but the mechanism by which it occurs remains elusive. In this study, microRNA-152 (miR-152) expression was induced by low oxygen levels in rat models of hypoxia brain damage, as well as in human brain microvascular endothelial cells (HBMECs) cultured in vitro. Analysis of the sequence of miR-152 revealed ... more

Y.H. Cao; D.G. Li; B. Xu; M.Q. Wang; N. Zhen; L.X. Man; Y.Y. Zhang; M. Chi; Y.H. Cao; D.G. Li; B. Xu; M.Q. Wang; N. Zhen; L.X. Man; Y.Y. Zhang; M. Chi
05/09/2016
Advanced glycation end-products; Chondrocytes; Matrix metalloproteinase-9; NF-κB; Reactive oxygen species; TGF-β

Peroxisome proliferator-activated receptor is closely associated with the pathogenesis of osteoarthritis. The level of exogenous advanced glycation end-products (AGEs) in articular cartilage is highly associated with the severity of osteoarthritic lesions. However, their interactions and role in promoting osteoarthritisprogression remain unclear. Here, we investigated the effect of AGEs ... more

J. Wang; G. Wang; G.W. Sun; J. Wang; G. Wang; G.W. Sun
04/26/2016
Antimutagenesis; Apoptosis; Campomanesia adamantium; Micronucleus; Mutagenesis

Campomanesia adamantium (Cambess.) O. Berg. is originally from Brazil. Its leaves and fruits have medicinal properties such as anti-inflammatory, antidiarrheal and antiseptic properties. However, the mutagenic potential of this species has been reported in few studies. This study describes the mutagenic/antimutagenic, splenic phagocytic, and apoptotic activities of C. ... more

M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira; M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira; M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira
04/25/2016
Apoptosis; Ndfipl; Parkinson’s disease; Ubiquitination

The aim of the current study was to examine the protective effects and mechanisms of Ndfipl on neurocytes in an experimental in vitro Parkinson’s disease model induced by MPP+. The cell model was developed with dominant negative expression and suppressed expression of Ndfipl by means of transient transfection of Ndfipl-dominant negative and -inhibitory vectors. In total, four ... more

L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan; L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan; L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan
04/07/2016
Apoptosis; Autophagy; Beclin-1; Colorectal cancer; MicroRNA-30a; Prognosis

We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance of Beclin-1 in CRC, while the weak expression of Beclin-1 in ... more

L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang; L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang; L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang
04/04/2016
Apoptosis; Gastric cancer; miR-451; MMP-2; Proliferation; Propofol

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 ... more

Z. Peng; Y. Zhang; Z. Peng; Y. Zhang; Z. Peng; Y. Zhang
04/04/2016
Apoptosis; Colorectal cancer; Invasion; MiR-874; Prognosis; Proliferation
X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi
06/24/2016
Apoptosis; Damage model; Light-induced damage; Retinal pigmented epithelium

To establish a blue-light damage model of human retinal pigment epithelium (RPE). Fourth-generation human RPE cells were randomly divided into two groups. In group A, cells were exposed to blue light (2000 ± 500 lux) for 0 (control), 3, 6, 9, and 12 h, and cell culture was stopped after 12 h. In group B, cells were exposed to blue light at the same intensity and time periods, but cell ... more

G. Su; S.J. Cai; X. Gong; L.L. Wang; H.H. Li; L.M. Wang; G. Su; S.J. Cai; X. Gong; L.L. Wang; H.H. Li; L.M. Wang
06/21/2016
Apoptosis; Bcl-2; Borax; HepG2 cells; Mitochondrial membrane potential; p53

Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlying the growth inhibition induced by borax in HepG2 cells. The ... more

Y. Wei; F.J. Yuan; W.B. Zhou; L. Wu; L. Chen; J.J. Wang; Y.S. Zhang; Y. Wei; F.J. Yuan; W.B. Zhou; L. Wu; L. Chen; J.J. Wang; Y.S. Zhang

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