Research Article

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Development-related genes; EZH2; Mouse; Transcriptional regulation; Trimethylation of H3K27

As a core member of polycomb repressive complex 2, the transcription and enzyme activity of enhancer of zeste homolog 2 (Ezh2) is directly involved in the trimethylation of lysine 27 on histone H3. In this study, the fluorescence intensity of H3K27me3 in mouse in vivo morulae and blastocysts was compared by indirect immunofluorescence staining. We found that demethylation of ... more

F.R. Wu; Y. Zhang; B. Ding; X.H. Lei; J.C. Huang; C.H. Wang; Y. Liu; R. Wang; W.Y. Li
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EZH2; Hepatocellular differentiation; Histone methyltransferase; mBMMSCs

Our previous studies have indicated that mouse bone marrow mesenchymal stem cells (mBMMSCs) have potential to differentiate into hepatocytes with high efficiency. Our study aimed to evaluate the role of the mouse histone methyltransferase enhancer of zeste homolog 2 gene (EZH2) in the hepatocellular differentiation of mBMMSCs. The mBMMSCs isolated from femurs and tibias were ... more

T. Lu; H. Sun; J. Lv; M.F. Yang; F. Zhang; Y. Qian; X.J. Dong
06/24/2016
Cervical cancer; Cervical intraepithelial neoplasia; Human papillomavirus; Screening

The aim of this study was to evaluate the performance of three new high-risk human papillomavirus (HPV) assays for primary cervical cancer screening, by using self-collected samples, and to identify an HPV assay that could overcome the major obstacles faced during large-scale population-based screening. Two hundred and ten women showing abnormal cervical cytology (and referred for a ... more

Q. Chen; H. Du; R. Zhang; J.H. Zhao; Q.C. Hu; C. Wang; G.X. Wang; J.L. Tang; R.F. Wu; Q. Chen; H. Du; R. Zhang; J.H. Zhao; Q.C. Hu; C. Wang; G.X. Wang; J.L. Tang; R.F. Wu
06/17/2016
Adhesion; Immunohistochemistry; Invasion; Medulloblastoma; Metastasis; MTA1

This study aims to investigate the expression of metastasis-associated gene 1 (MTA1) in human medulloblastoma, and its significance in the invasion and metastasis in a medulloblastoma cell line. Positive expression rate of MTA1 protein in medulloblastoma and adjacent normal tissues collected from 29 medulloblastoma patients was detected by immunohistochemistry assay in vivo. In ... more

Y.S. Chen; S.P. Li; H. Xiao; Z.Y. Xie; M.X. Tan; B. Liu; W.M. Zhang; Y.S. Chen; S.P. Li; H. Xiao; Z.Y. Xie; M.X. Tan; B. Liu; W.M. Zhang
09/08/2015
A431 cells; Apoptosis; Bcl-2; Berberine; Proliferation; Squamous cell carcinoma

Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-dependent manner and was observed to induce ... more

D.X. Li; J. Zhang; Y. Zhang; P.W. Zhao; L.M. Yang
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AIB1; Esophageal; Ki67; Squamous cell carcinoma

The aim of this study was to investigate the expression of AIB1 in human esophageal squamous cell carcinoma and its correlation with Ki67 expression. The immunohistochemical method streptavidin-perosidase was used to analyze the expression of AIB1 and Ki67 in specimens from 60 patients with esophageal squamous cell carcinoma and in 20 control individuals with normal esophageal tissue. ... more

L. Li; P. Wei; M.H. Zhang; W. Zhang; Y. Ma; X. Fang; C.L. Hao; Z.H. Zhang
03/30/2021
EGFR; Epidermal Growth Factor Receptor (ErbB-1; Her); Sinonasal cancer; SNSCC; Squamous cell carcinoma

Prognosis of sinonasal squamous cell carcinoma (SNSCC) depends on TNM (Tumor, Node, Metastasis) staging, histological manifestations, and activity of cell-surface receptors (p53, Ki67, EGFR − Epidermal Growth Factor Receptor (ErbB-1; Her1). EGFR is the best- studied transmembrane tyrosine kinase receptor. The intensity of tumor cells division and the rate of their ... more

N.D. Phuc; L.M. Ky; N.T. Binh; V.T.M. Thuc; N.T. Tuan; N.T.K. Van; T.X. Hai
2017 Feb 16
Cell differentiation; Colorectal neoplasms; Down-regulation; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lymphatic metastasis; male; Prognosis; Survival analysis

Kruppel-like factors (KLFs) are a group of transcriptional regulators that have recently been identified to exhibit tumor-suppressive function against various gastrointestinal cancers. The present study aims to investigate the expression patterns and prognostic value of KLF-4 in colorectal cancers (CRCs). KLF-4 levels in CRC tissues were examined via immunohistochemistry analysis, real-time ... more

D.H. Xiu; Y. Chen; L. Liu; H.S. Yang; G.F. Liu
2/16/2017
Adult; Aged; Aged, 80 and over; Arabs; Colorectal neoplasms; Exons; Female; Humans; male; Middle Aged; Mutation; Mutation Rate; Prognosis; Proto-Oncogene Proteins p21(ras); Retrospective Studies; Saudi Arabia; Survival analysis; Young Adult

Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian patients with CRC. The genetic status of K-ras was determined in ... more

J. Zekri; A. Al-Shehri; M. Mahrous; S. Al-Rehaily; T. Darwish; S. Bassi; E. Taani; A. Zahrani; S. Elsamany; J. Al-Maghrabi; B.B. Sadiq