Research Article

Related GMR Articles

04/28/2016
Coronary artery disease; IL-10-1082A/G; Polymorphism

We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and December 2014. Subjects were genotyped for IL-10 ... more

K. Liang; S.R. Dong; H. Peng; K. Liang; S.R. Dong; H. Peng; K. Liang; S.R. Dong; H. Peng
06/03/2016
Coronary artery disease; Endothelial nitric oxide synthase; Single nucleotide polymorphisms

The enzyme endothelial nitric oxide synthase (NOS3) is an important mediator of atherosclerotic disease and is associated with coronary artery disease (CAD). There is growing evidence that polymorphisms in NOS3 influence the progression of CAD; however, there is also a controversy regarding the association of polymorphisms in the gene encoding NOS3 and CAD. To determine if the ... more

G.L. Zhao; Q.J. Li; H.Y. Lu; G.L. Zhao; Q.J. Li; H.Y. Lu
05/13/2016
Coronary artery disease; Matrix metalloproteinase-9; Polymorphism

We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with control subjects, patients with coronary artery disease had ... more

L.M. Qin; G.M. Qin; X.H. Shi; A.L. Wang; H. Zuo; L.M. Qin; G.M. Qin; X.H. Shi; A.L. Wang; H. Zuo
08/12/2016
Chinese Han population; Coronary artery disease; Interleukin-17A; Single nucleotide polymorphisms

Coronary artery disease (CAD) is a major global health problem. In China, the incidence of CAD and the rate of mortality arising from it have increased every year. Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by activated T cells, and it may be involved in the development of CAD. Genetic polymorphisms in functional regions of the IL17A gene have a plausible role ... more

G.B. Su; X.L. Guo; X.C. Liu; Q.T. Cui; C.Y. Zhou; G.B. Su; X.L. Guo; X.C. Liu; Q.T. Cui; C.Y. Zhou
07/29/2016
Coronary artery disease; Nuclear factor-κB; Single nucleotide polymorphisms

Nuclear factor (NF)-κB is a transcription factor that controls cell proliferation, differentiation, and immunity. Activated NF-κB1 is associated with the pathogenesis of coronary artery disease (CAD) and genetic polymorphisms in NF-κB1 have a plausible role in modulating the risk of CAD. To identify markers that contribute to the genetic susceptibility to CAD, we examined the potential ... more

X.L. Guo; X.C. Liu; G.B. Su; C.Y. Zhou; Q.T. Cui; X.L. Guo; X.C. Liu; G.B. Su; C.Y. Zhou; Q.T. Cui
04/28/2016
16S rDNA; Pathogenicity island; Polymerase chain reaction; Polymorphism

Chromobacterium violaceum is a free-living Gram-negative bacillus usually found in the water and soil in tropical regions, which causes infections in humans. Chromobacteriosis is characterized by rapid dissemination and high mortality. The aim of this study was to detect the genetic variability among C. violaceum type strain ATCC 12472, and seven isolates from the ... more

A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa; A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa; A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa
04/26/2016
ERCC1; ERCC2; Gastric cancer; Polymorphism; Treatment outcome

We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platinum-based chemotherapy were recruited from the ... more

D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin
04/26/2016
Bladder cancer; CYP1A2; Polymorphism; Risk

To date, no study has investigated the association between CYP1A2-163C/A polymorphism and bladder cancer risk in a Chinese population. Here, we extracted genomic DNA from peripheral white blood cells, and differentiated CYP1A2 alleles by polymerase chain reaction-based restriction fragment length polymorphism methods. Differences in genotype frequencies between the cases ... more

Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu
04/28/2016
Esophageal cancer; Genetic variant; Polymorphism; Tumor necrosis factor-alpha
H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu
07/14/2016
Meta-analysis; Monoamine oxidase B; Parkinson’s disease; Polymorphism

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as ... more

J.J. Liu; W. Wang; M. Meng; C.S. Liang; J.W. Zhang

Pages