Research Article

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Cervical intraepithelial neoplasia; EZH2; Immunohistochemistry; p53 protein; Squamous cell carcinoma; Survival analysis

We investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) and p53 protein in cervical squamous cell carcinoma (SCC) and precancerous lesions. EZH2 and p53 expressions in SCC (168), cervical intraepithelial neoplasia (CIN)-I (19), CIN-II (35), and normal tissues (30) were detected by streptavidin-peroxidase-conjugation. The correlation between co- ... more

H.M. Zhang; S.Q. Chen; S.Z. Yao; H.M. Zhang; S.Q. Chen; S.Z. Yao
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Janus kinase 2; Metastasis; MicroRNA-204; NSCLC

Aberrant expression of microRNA is associated with the development and progression of cancers. MicroRNA-204 (miR-204) down-regulation has been previously demonstrated in non-small-cell lung carcinoma (NSCLC); however, the underlying mechanism by which miR-204 suppresses tumorigenesis in NSCLC remains elusive. In this study, miR-204 expression was found to be down-regulated, and that of ... more

P. Wang; H.Y. Lv; D.M. Zhou; E.N. Zhang; P. Wang; H.Y. Lv; D.M. Zhou; E.N. Zhang
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Chromosome instability; Colon cancer; Hec1; Metastasis; Nuclear division cycle 80; Proliferation

Chromosome instability is a common feature of tumor cells, and may be an important mechanism in tumor formation. Nuclear division cycle 80 (NDC80) is closely associated with the stability of chromosomes. Therefore, we investigated the relationship between NDC80 and development of colon cancer using a range of methods. Western blotting and immunohistochemistry were employed to determine ... more

X.K. Xing; H.Y. Wu; H.L. Chen; H.G. Feng; X.K. Xing; H.Y. Wu; H.L. Chen; H.G. Feng
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Apoptosis; Colorectal cancer; Invasion; MiR-874; Prognosis; Proliferation
X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi
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T. Tang; G.C. Zhang; C.F. Li; Y.F. Liu; W.Y. Wang; T. Tang; G.C. Zhang; C.F. Li; Y.F. Liu; W.Y. Wang; T. Tang; G.C. Zhang; C.F. Li; Y.F. Liu; W.Y. Wang
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Apoptosis; Invasion; MiR-32; Proliferation; Uveal melanoma

MicroRNA-32 (miR-32) has been shown to be dysregulated in some human malignancies and this has been found to be correlated with tumor progression. However, its role in uveal melanoma formation and progression remains largely unknown. Thus, the aim of this study was to explore the expression and function of miR-32 in human uveal melanoma. Using quantitative reverse transcription-polymerase ... more

Y.B. Ma; D.W. Song; R.H. Nie; G.Y. Mu
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Adolescent; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cerebellar Neoplasms; Child; Child, Preschool; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Infant; Medulloblastoma; Oxides; Signal transduction

Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different medulloblastoma subgroups described to date, the sonic hedgehog (SHH) genetic pathway is the pathway activated in the tumorigenesis of medulloblastoma. SHH-related medulloblastomas are usually of ... more

P.H.S. Klinger; A.F. Andrade; L.E.A. Delsin; R.G.P. Queiroz; C.A. Scrideli; L.G. Tone; E.T. Valera