Research Article

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05/12/2016
Apoptosis; Brain damage; Hypoxia; miR-152; PTEN

Brain damage caused by perinatal asphyxia is dangerous for neonatal infants, but the mechanism by which it occurs remains elusive. In this study, microRNA-152 (miR-152) expression was induced by low oxygen levels in rat models of hypoxia brain damage, as well as in human brain microvascular endothelial cells (HBMECs) cultured in vitro. Analysis of the sequence of miR-152 revealed ... more

Y.H. Cao; D.G. Li; B. Xu; M.Q. Wang; N. Zhen; L.X. Man; Y.Y. Zhang; M. Chi; Y.H. Cao; D.G. Li; B. Xu; M.Q. Wang; N. Zhen; L.X. Man; Y.Y. Zhang; M. Chi
05/09/2016
Apoptosis; Liver cancer; PTEN; Transfection

Liver cancer is a common malignant tumor associated with a short-survival period and high-mortality rate, and its prevalence in China is particularly high. This study aimed to investigate the effect of overexpressing the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene on liver cancer cell apoptosis and provide new insight into the treatment of this disease. ... more

M.F. Li; H. Guan; D.D. Zhang; M.F. Li; H. Guan; D.D. Zhang
05/06/2016
Apoptosis; LRIG1; Nude mice; Pituitary tumor; Proliferation

The aim of this study was to explore the inhibition of subcutaneously implanted human pituitary tumor cells in nude mice by LRIG1 and its mechanism. For this study, athymic nude mice were injected with either normal pituitary tumor RC-4B/C cells or LRIG1-transfected RC-4B/C cells. We then calculated the volume inhibition rate of the tumors, as well as the apoptosis index ... more

X. Wang; X.J. He; H.Q. Xu; Z.W. Chen; H.H. Fan; X. Wang; X.J. He; H.Q. Xu; Z.W. Chen; H.H. Fan
07/31/2015
Cervical carcinoma; FasL; Ki67; Prognosis

This study aimed to investigate the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma and to explore the biological processes and signal pathways related to cervical carcinoma. Cervical carcinoma tissue specimens from 200 patients and normal tissue specimens adjacent to lesions from 30 cases were collected in this study. Ki67 and FasL proteins in ... more

S.N. Liang; Y.J. Huang; L.L. Liu; X. Liu

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