Research Article

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12/02/2015
Different tail type; FAS; HSL; mRNA and protein expression; PPARγ; Sheep

Tail fat content affects meat quality, and it varies in different sheep breeds. Theoretically, lipid metabolism contributes to variation in tail fat content. Tail length, tail width, and tail girth were measured in live Tong sheep (with both short fat tail and long fat tail), Shaanbei fine wool sheep (long thin tail), Tan sheep (short fat tail), Kazakh sheep (hip fat tail), and Tibetan sheep ( ... more

X.C. Xu; B.B. Li; X. Wei; Y.X. Yang; X.L. Wang; Y.L. Chen
04/26/2016
Antimutagenesis; Apoptosis; Campomanesia adamantium; Micronucleus; Mutagenesis

Campomanesia adamantium (Cambess.) O. Berg. is originally from Brazil. Its leaves and fruits have medicinal properties such as anti-inflammatory, antidiarrheal and antiseptic properties. However, the mutagenic potential of this species has been reported in few studies. This study describes the mutagenic/antimutagenic, splenic phagocytic, and apoptotic activities of C. ... more

M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira; M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira; M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira
04/25/2016
Apoptosis; Ndfipl; Parkinson’s disease; Ubiquitination

The aim of the current study was to examine the protective effects and mechanisms of Ndfipl on neurocytes in an experimental in vitro Parkinson’s disease model induced by MPP+. The cell model was developed with dominant negative expression and suppressed expression of Ndfipl by means of transient transfection of Ndfipl-dominant negative and -inhibitory vectors. In total, four ... more

L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan; L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan; L.F. Xing; H.P. Guo; D.T. Wang; L.H. Sun; S.Y. Pan
04/07/2016
Apoptosis; Autophagy; Beclin-1; Colorectal cancer; MicroRNA-30a; Prognosis

We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance of Beclin-1 in CRC, while the weak expression of Beclin-1 in ... more

L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang; L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang; L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang
04/04/2016
Apoptosis; Gastric cancer; miR-451; MMP-2; Proliferation; Propofol

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 ... more

Z. Peng; Y. Zhang; Z. Peng; Y. Zhang; Z. Peng; Y. Zhang
04/04/2016
Apoptosis; Colorectal cancer; Invasion; MiR-874; Prognosis; Proliferation
X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi
06/24/2016
Apoptosis; Damage model; Light-induced damage; Retinal pigmented epithelium

To establish a blue-light damage model of human retinal pigment epithelium (RPE). Fourth-generation human RPE cells were randomly divided into two groups. In group A, cells were exposed to blue light (2000 ± 500 lux) for 0 (control), 3, 6, 9, and 12 h, and cell culture was stopped after 12 h. In group B, cells were exposed to blue light at the same intensity and time periods, but cell ... more

G. Su; S.J. Cai; X. Gong; L.L. Wang; H.H. Li; L.M. Wang; G. Su; S.J. Cai; X. Gong; L.L. Wang; H.H. Li; L.M. Wang
06/21/2016
Apoptosis; Bcl-2; Borax; HepG2 cells; Mitochondrial membrane potential; p53

Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlying the growth inhibition induced by borax in HepG2 cells. The ... more

Y. Wei; F.J. Yuan; W.B. Zhou; L. Wu; L. Chen; J.J. Wang; Y.S. Zhang; Y. Wei; F.J. Yuan; W.B. Zhou; L. Wu; L. Chen; J.J. Wang; Y.S. Zhang
06/10/2016
Apoptosis; Chondrocytes; CREB phosphorylation; Hypoxia; Mitochondrial dysfunction

Chondrocytes, which are embedded within the growth-plate or the intervertebral disc, are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signaling pathways underlying hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes. We first examined the apoptosis, caspase-3 activity, and apoptosis-associated ... more

Y.Y. Qiu; Y. Chen; T.H. Zeng; W.H. Guo; W.Y. Zhou; X.J. Yang; Y.Y. Qiu; Y. Chen; T.H. Zeng; W.H. Guo; W.Y. Zhou; X.J. Yang
05/13/2016
Apoptosis; Invasion; MiR-32; Proliferation; Uveal melanoma

MicroRNA-32 (miR-32) has been shown to be dysregulated in some human malignancies and this has been found to be correlated with tumor progression. However, its role in uveal melanoma formation and progression remains largely unknown. Thus, the aim of this study was to explore the expression and function of miR-32 in human uveal melanoma. Using quantitative reverse transcription-polymerase ... more

Y.B. Ma; D.W. Song; R.H. Nie; G.Y. Mu

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