Research Article

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In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response ... more

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SNX-2112 is a potential molecular targeted therapeutic drug against esophageal cancer (EC). However, its exact mechanism of action remains to be explained. The aim of this study was to investigate the effect of SNX-2112 on excision repair cross- complementing 1 (ERCC1), epidermal growth factor receptor (EGFR), and p53, to elucidate the mechanism of action of SNX-2112 on EC. Fresh tumor ... more

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Antimutagenesis; Apoptosis; Campomanesia adamantium; Micronucleus; Mutagenesis

Campomanesia adamantium (Cambess.) O. Berg. is originally from Brazil. Its leaves and fruits have medicinal properties such as anti-inflammatory, antidiarrheal and antiseptic properties. However, the mutagenic potential of this species has been reported in few studies. This study describes the mutagenic/antimutagenic, splenic phagocytic, and apoptotic activities of C. ... more

M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira; M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira; M.D. Martello; N. David; R. Matuo; P.C. Carvalho; S.D. Navarro; A.C.D. Monreal; A.L. Cunha-Laura; C.A.L. Cardoso; C.A.L. Kassuya; R.J. Oliveira
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Apoptosis; Ndfipl; Parkinson’s disease; Ubiquitination

The aim of the current study was to examine the protective effects and mechanisms of Ndfipl on neurocytes in an experimental in vitro Parkinson’s disease model induced by MPP+. The cell model was developed with dominant negative expression and suppressed expression of Ndfipl by means of transient transfection of Ndfipl-dominant negative and -inhibitory vectors. In total, four ... more

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Apoptosis; Autophagy; Beclin-1; Colorectal cancer; MicroRNA-30a; Prognosis

We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance of Beclin-1 in CRC, while the weak expression of Beclin-1 in ... more

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Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 ... more

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Apoptosis; Colorectal cancer; Invasion; MiR-874; Prognosis; Proliferation
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Apoptosis; Damage model; Light-induced damage; Retinal pigmented epithelium

To establish a blue-light damage model of human retinal pigment epithelium (RPE). Fourth-generation human RPE cells were randomly divided into two groups. In group A, cells were exposed to blue light (2000 ± 500 lux) for 0 (control), 3, 6, 9, and 12 h, and cell culture was stopped after 12 h. In group B, cells were exposed to blue light at the same intensity and time periods, but cell ... more

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Apoptosis; FAS; FasL; Viral myocarditis

The aim of the current study was to investigate Fas and FasL expression and myocardial cell apoptosis in viral myocarditis patients. Human heart specimens were selected from patients who were autopsied between February 2012 and February 2015; of these, 25 patients were diagnosed with viral myocarditis. Another 15 cases with no diagnosis of myocarditis were selected for the control group ... more

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Apoptosis; Chondrocytes; CREB phosphorylation; Hypoxia; Mitochondrial dysfunction

Chondrocytes, which are embedded within the growth-plate or the intervertebral disc, are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signaling pathways underlying hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes. We first examined the apoptosis, caspase-3 activity, and apoptosis-associated ... more

Y.Y. Qiu; Y. Chen; T.H. Zeng; W.H. Guo; W.Y. Zhou; X.J. Yang; Y.Y. Qiu; Y. Chen; T.H. Zeng; W.H. Guo; W.Y. Zhou; X.J. Yang

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