Research Article

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11/18/2013
-308G>A; Breast cancer; Mexican population; Obesity; Risk factor; Tumor necrosis factor alpha

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with ... more

G. Flores-Ramos; E. De Dios; A.M. Puebla-Pérez; L.E. Figuera-Villanueva; A. Ramos-Silva; R. Ramírez-Patiño; J.I. Delgado-Saucedo; E. Salas-González; G.M. Zúñiga-González; A. Alonzo-Rojo; I. Gutiérrez-Hurtado; M.P. Gallegos-Arreola
06/03/2016
25-(OH)2D3]; Active vitamin D3 [1; Endothelin; Macrovasculopathy; T2DM; TNF-α

To investigate the protective effect of the active form of vitamin D3, 1,25-(OH)2D3, on macrovasculopathy in rats with type 2 diabetes mellitus (T2DM), 8-week-old male Sprague-Dawley rats were randomly divided into control group, T2DM group, and treatment group. The T2DM model was established after 6 weeks by administering an intraperitoneal injection of ... more

R. Ma; X.L. Deng; G.L. Du; C. Li; S. Xiao; Y. Aibibai; J. Zhu; R. Ma; X.L. Deng; G.L. Du; C. Li; S. Xiao; Y. Aibibai; J. Zhu
07/14/2016
Buffalo; Haplotype; MC4R gene; Milk production; SNP

Melanocortin-4 receptor (MC4R) is associated with feed intake, growth, fatness, and carcass composition in many domestic animals. The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in MC4R with milk production traits in water buffalo. Eight SNPs were identified by direct polymerase chain reaction sequencing of samples from 18 ... more

T.X. Deng; C.Y. Pang; M.Q. Liu; C. Zhang; X.W. Liang; T.X. Deng; C.Y. Pang; M.Q. Liu; C. Zhang; X.W. Liang
05/13/2016
Association analysis; Breast cancer; Genetic variants; Haplotype; Hormone-related gene

Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) in five hormone-related genes: estrogen receptor-α (ESR1 ... more

Z. Pan; Z. Fu; Q. Song; W. Cao; W. Cheng; X. Xu; Z. Pan; Z. Fu; Q. Song; W. Cao; W. Cheng; X. Xu
04/26/2016
Colorectal cancer; High-resolution melting; Mismatch repair gene; Single nucleotide polymorphism

Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese patients. Therefore, the present study aimed to ... more

H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin; H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin; H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin
04/07/2016
Apoptosis; Autophagy; Beclin-1; Colorectal cancer; MicroRNA-30a; Prognosis

We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance of Beclin-1 in CRC, while the weak expression of Beclin-1 in ... more

L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang; L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang; L. Liu; T. Meng; Q.S. Wang; H.Z. Jin; Z.Q. Sun; B. Jin; F. Fang; H.J. Wang
04/04/2016
Apoptosis; Colorectal cancer; Invasion; MiR-874; Prognosis; Proliferation
X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi; X.J. Wang; M. Xia; W.P. Bi
05/23/2016
Colorectal cancer; Invasion; miR-452; Prognosis; Proliferation
T. Tang; G.C. Zhang; C.F. Li; Y.F. Liu; W.Y. Wang; T. Tang; G.C. Zhang; C.F. Li; Y.F. Liu; W.Y. Wang; T. Tang; G.C. Zhang; C.F. Li; Y.F. Liu; W.Y. Wang
05/13/2016
Back-propagation neural network; Colorectal cancer; Logistic regression analysis; Serum marker; Support vector machine

We evaluated the application of three machine learning algorithms, including logistic regression, support vector machine and back-propagation neural network, for diagnosing congenital heart disease and colorectal cancer. By inspecting related serum tumor marker levels in colorectal cancer patients and healthy subjects, early diagnosis models for colorectal cancer were built using three ... more

B. Zhang; X.L. Liang; H.Y. Gao; L.S. Ye; Y.G. Wang; B. Zhang; X.L. Liang; H.Y. Gao; L.S. Ye; Y.G. Wang
05/06/2016
BK polyomavirus; BKV; Colorectal cancer

The development of human neoplasms can be provoked by exposure to one of several viruses. Burkitt lymphoma, cervical carcinoma, and hepatocellular carcinoma are associated with Epstein-Barr, human papilloma, and hepatitis B virus infections, respectively. Over the past three decades, many studies have attempted to establish an association between colorectal cancer and viruses, with ... more

M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; A.A. Basuni; D.A. Elderwi; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; A.A. Basuni; D.A. Elderwi

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