Research Article

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07/14/2016

Exome sequencing in Thai patients with familial obesity

Body mass index; Exome sequencing; Gene; Obesity; Thailand; Variants

Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of cancer. Previous genome-wide association studies have ... more

S. Kaewsutthi; J. Santiprabhob; B. Phonrat; A. Tungtrongchitr; P. Lertrit; R. Tungtrongchitr
07/14/2016

Exome sequencing in Thai patients with familial obesity

Body mass index; Exome sequencing; Gene; Obesity; Thailand; Variants

Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of cancer. Previous genome-wide association studies have ... more

S. Kaewsutthi; J. Santiprabhob; B. Phonrat; A. Tungtrongchitr; P. Lertrit; R. Tungtrongchitr; S. Kaewsutthi; J. Santiprabhob; B. Phonrat; A. Tungtrongchitr; P. Lertrit; R. Tungtrongchitr
04/26/2016

Mutagenic influences of colchicine on phenological and molecular diversity of Calendula officinalis L.

Calendula; Colchicine; Flowering yield; Molecular diversity; Mutation; SRAP

Six different colchicine concentrations: 0, 400, 800, 1200, 1600, and 2000 ppm, in combination with four soaking time treatments (1, 2, 3, and 4 h), were selected to assess the effects on germination, vegetative growth, and flower yield components in calendula plants. The molecular diversity among the treatments was assessed using ten SRAP marker combinations. Seed soaking in colchicine ... more

Y.I. El-Nashar; M.H. Ammar; Y.I. El-Nashar; M.H. Ammar; Y.I. El-Nashar; M.H. Ammar
06/03/2016

Screening for mutations in RPGR and RP2 genes in Jordanian families with X-linked retinitis pigmentosa

Mutation; Retinitis pigmentosa; RP2; RPGR; X-linked

Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous disease causing progressive degeneration of retinal photoreceptor cells. X-linked RP (XLRP), in which photoreceptor degeneration begins in early childhood and complete blindness often occurs by the fourth decade of life, constitutes the most severe form of this disease. Two genes commonly associated with XLRP have ... more

M.F. Haddad; O.F. Khabour; K.A.Y. Abuzaideh; W. Shihadeh; M.F. Haddad; O.F. Khabour; K.A.Y. Abuzaideh; W. Shihadeh
05/13/2016

Molecular characterization of a Han Chinese family with essential hypertension

Chinese family; Hypertension; mtDNA; Mutation

Mutations in the mitochondrial genome have been found to be associated with essential hypertension. Here, we report the clinical and molecular characterization of a three-generation Han Chinese family with maternally inherited hypertension. Most strikingly, this pedigree exhibited a high penetrance of hypertension. Sequence analysis of the mitochondrial genome showed the presence of a ... more

J.F. Zhu; X. Zhang; L. Ling; J.F. Zhu; X. Zhang; L. Ling
05/06/2016

Phenotypic and biochemical profile changes in calendula (Calendula officinalis L.) plants treated with two chemical mutagenesis

Diethyl sulfate; Enzyme activity; Gas-exchange; Mutation; Sodium azide

Chemical mutagenesis is an efficient tool used in mutation-breeding programs to improve the vital characters of the floricultural crops. This study aimed to estimate the effects of different concentrations of two chemical mutagens; sodium azide (SA) and diethyl sulfate (DES). The vegetative growth and flowering characteristics in two generations (M1 and M2) of ... more

Y.I. El-Nashar; A.A. Asrar; Y.I. El-Nashar; A.A. Asrar