Research Article

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Breast cancer is the second most common cancer worldwide and the first among women. Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological subtypes, and the clinical and molecular differences between them justify the search for new markers to distinguish them. As proteomic analysis allows for a powerful and analytical approach to identify ... more

N.C.S. Oliveira; T.H.B. Gomig; H.H. Milioli; F. Cordeiro; G.G. Costa; C.A. Urban; R.S. Lima; I.J. Cavalli; E.M.S.F. Ribeiro; N.C.S. Oliveira; T.H.B. Gomig; H.H. Milioli; F. Cordeiro; G.G. Costa; C.A. Urban; R.S. Lima; I.J. Cavalli; E.M.S.F. Ribeiro; N.C.S. Oliveira; T.H.B. Gomig; H.H. Milioli; F. Cordeiro; G.G. Costa; C.A. Urban; R.S. Lima; I.J. Cavalli; E.M.S.F. Ribeiro
07/14/2016
Breast cancer; DNA methylation; Gene promoter; RASSFIA gene
Y. Ji; H.H. Jin; M.D. Wang; W.X. Cao; J.L. Bao; Y. Ji; H.H. Jin; M.D. Wang; W.X. Cao; J.L. Bao; Y. Ji; H.H. Jin; M.D. Wang; W.X. Cao; J.L. Bao
07/14/2016
Breast cancer; Co-expression network; Eribulin; Hub genes; Paclitaxel; Pathway-enrichment analysis

We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially co-expressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes were validated using the polymerase chain reaction and western ... more

J. Qin; Y.H. Chen; J. Qin; Y.H. Chen
06/16/2016
Breast cancer; GSTP1; Meta-analysis; Polymorphism

Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this meta-analysis was conducted to obtain a ... more

M. Kuang; W. Xu; C.X. Cao; L.L. Shen; J. Chang; X.L. Zhang; J.F. Chen; C.J. Tang; M. Kuang; W. Xu; C.X. Cao; L.L. Shen; J. Chang; X.L. Zhang; J.F. Chen; C.J. Tang
07/14/2016
Breast cancer; Diabetes mellitus; miR-221/222

The aim of the research was to examine the expression level of microRNA221/222 (miR-221/222) in the serum of patients with type 2 diabetes mellitus (T2DM) who are also diagnosed with post-menopausal breast cancer. We aimed to evaluate the differences in microRNA expression in patients with T2DM alone, patients with post-menopausal breast cancer alone, and patients with both T2DM and post ... more

M.Y. Li; S.R. Pan; A.Y. Qiu; M.Y. Li; S.R. Pan; A.Y. Qiu
06/30/2016
Breast cancer; Ezrin; Interaction; p65

Our study aimed to investigate the co-localization and protein-protein interactions between ezrin and p65 in human breast cancer cells. Liquid chromatography-mass spectrometry (LCMS) was used to uncover novel protein interactions with ezrin in MDA-MB-231 cells. Endogenous co-immunoprecipitation was used to validate protein-protein interactions between ezrin and p65 in MDA-MB-231. ... more

R. Tang; F.X. Li; W.F. Shao; Q.S. Wen; X.R. Yu; J.B. Xiong; R. Tang; F.X. Li; W.F. Shao; Q.S. Wen; X.R. Yu; J.B. Xiong
06/03/2016
Breast cancer; Chinese population; Polymorphism; XPG

We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of XPG rs2094258, rs751402, and rs17655 was performed using ... more

S.H. Ma; F.H. Ling; Y.X. Sun; S.F. Chen; Z. Li; S.H. Ma; F.H. Ling; Y.X. Sun; S.F. Chen; Z. Li
05/20/2016
Breast cancer; Proliferation; Resveratrol; Tristetraprolin

Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associated with the abnormal expression of multiple cytokines. ... more

C. Li; C. Tang; G. He; C. Li; C. Tang; G. He
05/13/2016
Association analysis; Breast cancer; Genetic variants; Haplotype; Hormone-related gene

Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) in five hormone-related genes: estrogen receptor-α (ESR1 ... more

Z. Pan; Z. Fu; Q. Song; W. Cao; W. Cheng; X. Xu; Z. Pan; Z. Fu; Q. Song; W. Cao; W. Cheng; X. Xu
05/12/2016
Breast cancer; Keap1; Prognosis

Our objective was to explore the expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 (Keap1) in breast cancer tissue. Eighty-one breast cancer patients having undergone surgical treatment in our hospital between March 2002 and December 2008 were enrolled in this study. Normal tissue adjacent to tumors was used for the control samples. Diagnoses for all ... more

L. Zhang; W.P. Yang; L.Y. Wu; X. Zhu; C.Y. Wei; L. Zhang; W.P. Yang; L.Y. Wu; X. Zhu; C.Y. Wei

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