Research Article

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04/07/2016
A1298C; C677T; Lung cancer; Meta-analysis; MTHFR; Polymorphisms

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource ... more

Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu
06/03/2016
A1298C; MTHFR; Neural tube defects; Polymorphism

The etiology underlying neural tube defects (NTDs) is not fully understood and is believed to involve a complex milieu of genetic and environmental factors. The A1298C polymorphism in the methylenetetrahydropholate reductase gene (MTHFR) has been associated with mild risk for NTDs. In this study, the genotype distribution of the MTHFR gene A1298C polymorphism and the ... more

S.H. Yildiz; O. Erdogan; M. Solak; O. Eser; E.S.Arıkan Terzi; B. Eser; V. Kocabaş; A. Aslan; S.H. Yildiz; O. Erdogan; M. Solak; O. Eser; E.S.Arıkan Terzi; B. Eser; V. Kocabaş; A. Aslan
03/28/2016
Genetic polymorphism; Hypertension; MTHFR; Risk factors

The association of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and essential hypertension has been reported but with controversial results in diverse populations in Asia and Europe, thereby suggesting a dependency on ethnicity. The aim of this study was to investigate the association between the MTHFR C677T polymorphism and essential ... more

S.M. Ghogomu; N.E. Ngolle; R.N. Mouliom; B.F. Asa; S.M. Ghogomu; N.E. Ngolle; R.N. Mouliom; B.F. Asa; S.M. Ghogomu; N.E. Ngolle; R.N. Mouliom; B.F. Asa
06/03/2016
AZF; Azoospermia; Male infertility; Microdeletion; Y chromosome

Dyszoospermia due to genetic factors is the leading cause of male infertility. To explore the correlation between azoospermia factor (AZF) microdeletion of the Y chromosome and male infertility, we evaluated AZF microdeletion on the long arm of the Y chromosome in 166 infertile males and 50 fertile males using multiplex polymerase chain reactions amplification and gel electrophoresis. The ... more

X.G. Liu; H.Y. Hu; Y.H. Guo; Y.P. Sun; X.G. Liu; H.Y. Hu; Y.H. Guo; Y.P. Sun
10/05/2016
Balanced translocation; Breakpoint; Chromosome 1; Genetic counseling; Male infertility

Reciprocal translocation is closely associated with male infertility and recurrent miscarriages. Balanced reciprocal translocations associated with reproductive failures are predominantly observed on chromosome 1. Additionally, infertile male patients present a number of breakpoints throughout chromosome 1. A translocation breakpoint might interrupt the structure of an important gene, ... more

R.X. Wang; H.G. Zhang; Y. Pan; S. Chen; F.G. Yue; D.L. Zhu; R.Z. Liu; R.X. Wang; H.G. Zhang; Y. Pan; S. Chen; F.G. Yue; D.L. Zhu; R.Z. Liu
04/27/2016
Espírito Santo-Brazil; Hereditary hemochromatosis; HFE gene; Iron metabolism disorders; Iron overload; Polymorphisms

Hereditary hemochromatosis (HH) is an autosomal recessive disorder that leads to progressive iron accumulation and may cause cirrhosis, hepatocellular carcinoma, diabetes, and heart failure. Most cases of HH have been linked to mutations in genes associated with iron homeostasis. There have been three major variants in the high Fe (HFE) gene associated with the disease: C282Y, ... more

L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro; L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro; L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro
06/24/2016
Hepatocellular carcinoma; mt-tRNA; mutations; Polymorphisms

Mitochondrial DNA mutations have been shown to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). In particular, genes encoding mitochondrial tRNA (mt-tRNA) are hotspots for pathogenic mutations associated with HCC. Recently, an increasing number of studies have reported the involvement of such mutations in this disease. As a result, several mt-tRNA mutations ... more

G. Li; Y.X. Duan; X.B. Zhang; F. Wu; G. Li; Y.X. Duan; X.B. Zhang; F. Wu
04/27/2016
Chronic obstructive pulmonary disease; Epoxide hydrolase 1; Meta-analysis; Nonsynonymous single-nucleotide polymorphisms; Variable threshold

Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. In recent years, as one of the most widely studied genes ... more

L. An; H. Xia; P. Zhou; L. Hua; L. An; H. Xia; P. Zhou; L. Hua; L. An; H. Xia; P. Zhou; L. Hua
04/25/2016
Meta-analysis; Methylation; Promoter; RASSF1A; Renal cell cancer

Epigenetic inactivation of Ras-associated domain family 1A (RASSF1A) by hyper-methylation of its promoter region has been identified in various cancers. However, the role of RASSF1A in renal cancer has neither been thoroughly investigated nor reviewed. In this study, we reviewed and performed a meta-analysis of 13 published studies reporting correlations between ... more

Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen; Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen; Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen
04/04/2016
135G/C polymorphism; Acute myeloid leukemia; Meta-analysis; RAD51

Numerous studies have evaluated the association between the 135G/C polymorphism in the RAD51 gene and risk of acute myeloid leukemia (AML), but the results have been inconsistent. The aim of this study is to precisely examine the association between the 135G/C polymorphism in the RAD51 gene and AML risk through a meta-analysis. PubMed, Google Scholar, and Web of Science databases were ... more

L. Wu; Z.G. Long; Z.S. Dai; L. Wu; Z.G. Long; Z.S. Dai; L. Wu; Z.G. Long; Z.S. Dai

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