Research Article

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04/26/2016
Gastric cancer; miR-204; Prognosis; Serum

Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluate the expression level of serum miR-204 in patients with GC. ... more

X. Chen; X.S. Liu; H.Y. Liu; Y.Y. Lu; Y. Li; X. Chen; X.S. Liu; H.Y. Liu; Y.Y. Lu; Y. Li; X. Chen; X.S. Liu; H.Y. Liu; Y.Y. Lu; Y. Li
04/29/2016
Cell apoptosis; Death receptor; Endoplasmic reticulum; Liver regeneration; Partial hepatectomy

The death receptor and endoplasmic reticulum (ER) are closely related to cell apoptosis, and it is worth studying whether the apoptosis pathways mediated by them are involved in liver regeneration. To understand the mechanism underlying death receptor- and ER-mediated apoptosis during rat liver regeneration, we used the Rat Genome 230 2.0 Array to determine the changes in gene expression ... more

X.K. Xing; M.H. Li; X.S. Zhu; C.S. Xu; X.K. Xing; M.H. Li; X.S. Zhu; C.S. Xu
03/04/2016
5-Fluorouracil; Cell apoptosis; Colorectal cancer cell HCT116; Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) protein; Malignant proliferation

5-Fluorouracil (5-FU) is widely used in chemotherapy for treatment of colorectal cancer. Leucine-rich repeat-containing G protein-coupled receptor (LGR) is known to participate in the occurrence and development of breast cancer by regulating the rebirth of tumor vessels. This study aimed to explore the proliferation and apoptosis of HCT116 colorectal cancer cells treated with 5-FU and ... more

J.T. Zhang; W.L. Zhou; C. He; T. Liu; C.Y. Li; L. Wang; J.T. Zhang; W.L. Zhou; C. He; T. Liu; C.Y. Li; L. Wang
06/24/2016
Cell apoptosis; DNA damage; Mitochondrial damage; Oxidative stress; Uric acid

Here, we investigated the effect of uric acid (UA) on hepatocyte mitochondria. Hepatocytes cultured in vitro were treated with varying concentrations of UA. The change in apoptotic activity was detected by flow cytometry. The DNA damage index 8-hydroxy-deoxy-guanosine (8-OHdG) and mitochondrial function indices succinate dehydrogenase (SDH), cytochrome C oxidase (CCO), and ... more

Y. Yang; Y. Zhou; S. Cheng; J.L. Sun; H. Yao; L. Ma; Y. Yang; Y. Zhou; S. Cheng; J.L. Sun; H. Yao; L. Ma
06/03/2016
Cell apoptosis; Lentivirus; Toll-like receptor 4

The aim of this study was to observe the proliferation of, and cell-cycle changes in, the human lens epithelial cell line HLEC after Toll-like receptor 4 (TLR4) gene silencing. HLEC cells were transfected with four TLR4-short hairpin RNA (shRNA) lentiviral vectors or the control lentivirus (pGCL-GFP-shRP-1, -2, -3, -4, NC). TLR4 silencing was verified in these cells 96 h ... more

H.T. Yu; P.R. Lu; H.T. Yu; P.R. Lu
06/03/2016
Cell apoptosis; FAS/FASL gene pair; MicroRNA-98; Myocarditis

Myocarditis is a common cardiovascular disease and frequently occurs in children and teenagers. It is believed to be caused by both endogenous and exogenous factors, among which FAS/FASL gene pair-induced cell apoptosis is a major mechanism of myocardial cell injury. A previous study has detected low expression of microRNA (miR)-98 in myocarditis patients. Therefore, in this ... more

B.Y. Zhang; Z. Zhao; Z. Jin; B.Y. Zhang; Z. Zhao; Z. Jin
05/20/2016
Acute myocardial infarction; Cell apoptosis; Necrostatin-1

The aim of this study was to investigate the protective effect of necrostatin-1 on myocardial tissue of acute myocardial infarction (AMI) rats and to provide a basis for necrostatin-1 for the treatment of acute myocardial infarction. AMI rats (45) were established by ligating the anterior descending branch of the left coronary artery. The rats were randomly divided into the model group ... more

Y.R. Liu; H.M. Xu; Y.R. Liu; H.M. Xu
04/28/2016
Gastric cancer; Genotype; Pre-miR-196a2; Rs11614913

We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People’s Hospital. For SNP genotyping, we used the Assay Designer 3.1 to design the ... more

M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei; M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei; M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei
04/26/2016
ERCC1; ERCC2; Gastric cancer; Polymorphism; Treatment outcome

We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platinum-based chemotherapy were recruited from the ... more

D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin
04/04/2016
Apoptosis; Gastric cancer; miR-451; MMP-2; Proliferation; Propofol

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 ... more

Z. Peng; Y. Zhang; Z. Peng; Y. Zhang; Z. Peng; Y. Zhang

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