Research Article

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05/09/2016
Diabetic nephropathy; IL-10 -1082G/A; IL-10 -592A/C; IL-10 -819T/C; Polymorphism

In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polymerase chain reaction-restriction ... more

D.H. Ma; Q.Y. Xu; Y. Liu; Q.Q. Zhai; M.H. Guo; D.H. Ma; Q.Y. Xu; Y. Liu; Q.Q. Zhai; M.H. Guo
04/28/2016
Gastric cancer; Genotype; Pre-miR-196a2; Rs11614913

We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People’s Hospital. For SNP genotyping, we used the Assay Designer 3.1 to design the ... more

M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei; M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei; M. Li; R.J. Li; H. Bai; P. Xiao; G.J. Liu; Y.W. Guo; J.Z. Mei
04/26/2016
Cell apoptosis; Cyclosporin A; Expression level; Gastric cancer

Human health is significantly threatened by gastric cancer, which is the most common malignant tumor; although drastic, surgery is currently the only way to cure it. However, high recurrence rates and low survival rates are associated with the disease. Therefore, to improve the effectiveness of gastric cancer treatment and to increase the clinical cure rate, we investigated the effect of ... more

X.L. Xing; Y. Lu; H.L. Qiu; X.L. Xing; Y. Lu; H.L. Qiu; X.L. Xing; Y. Lu; H.L. Qiu
04/26/2016
Gastric cancer; miR-204; Prognosis; Serum

Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluate the expression level of serum miR-204 in patients with GC. ... more

X. Chen; X.S. Liu; H.Y. Liu; Y.Y. Lu; Y. Li; X. Chen; X.S. Liu; H.Y. Liu; Y.Y. Lu; Y. Li; X. Chen; X.S. Liu; H.Y. Liu; Y.Y. Lu; Y. Li
04/04/2016
Apoptosis; Gastric cancer; miR-451; MMP-2; Proliferation; Propofol

Propofol is an extensively used intravenous anesthetic agent. The aim of the present study was to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms associated with this activity. The effects of propofol on proliferation and apoptosis in the SGC-7901 gastric cancer cell line were detected by an MTT assay and measurement of caspase-3 ... more

Z. Peng; Y. Zhang; Z. Peng; Y. Zhang; Z. Peng; Y. Zhang
06/02/2016
Expression; Progression; Gastric cancer; miR-218

The aim of the present study was to investigate the clinical significance of microRNA-218 (miR-218) in gastric cancer. We enrolled 112 patients having undergone surgery for gastric cancer between May 2008 and June 2014. Expression of miR-218 was determined by real-time quantitative reverse transcription-polymerase chain reaction. Survival curves were plotted using the Kaplan-Meier method ... more

X.X. Wang; S.J. Ge; X.L. Wang; L.X. Jiang; M.F. Sheng; J.J. Ma; X.X. Wang; S.J. Ge; X.L. Wang; L.X. Jiang; M.F. Sheng; J.J. Ma
09/16/2016
CDH1; E-cadherin; Gastric cancer; Polymorphisms

Gastric cancer (GC), the third leading cause of cancer-related deaths in Mexico and worldwide, can be classified into diffuse (DGC) or intestinal (IGC) types based on its histological characteristics. DGC is characterized by reduced expression of the cell adhesion protein E-cadherin, which is encoded by CDH1. The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in ... more

A.R. Bustos-Carpinteyro; N. Delgado-Figueroa; E. Santiago-Luna; M.T. Magaña-Torres; J.Y. Sánchez-López; A.R. Bustos-Carpinteyro; N. Delgado-Figueroa; E. Santiago-Luna; M.T. Magaña-Torres; J.Y. Sánchez-López
12/02/2016
Animals; Citalopram; Dementia, Vascular; Disease Models, Animal; Dopamine; Gene Expression Regulation; Hippocampus; Humans; Injections, Intraperitoneal; male; Neurons; Norepinephrine; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin; Treatment outcome

5-hydroxytryptamine receptor 1A (5-HT1AR) is closely associated with cognitive functions. Selective serotonin reuptake inhibitors (SSRIs) can protect individuals from brain damage following ischemia/hypoxia. To investigate the function of SSRIs in vascular dementia (VD), we established a rat model of VD, and observed the effect of SSRIs on the expression of 5-HT1AR mRNA and neurotransmitters. ... more

K. Guo; G. Yin; X.H. Zi; H.X. Zhu; Q. Pan
12/19/2016
Female; Gene frequency; Genetic markers; Humans; Immunologic Factors; Intravitreal Injections; Macular Degeneration; male; Polymorphism, Genetic; Precision Medicine; Proteins; Ranibizumab; Sequence Analysis, DNA; Treatment outcome

Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries. The ARMS2 gene has been found to be associated with AMD. Currently, intravitreal ranibizumab (IVR) treatment is one of the widely used treatments for neovascular AMD. The aim of this study was to investigate the association between the genotype of ARMS2 rs10490924 polymorphism and IVR treatment ... more

H. Bardak; Y. Bardak; Y. Ercalik; T. Kumral; S. Imamoglu; M. Gunay; H. Ozbas; O. Bagci
12/23/2016
Alleles; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; DNA-Binding Proteins; Genotype; Humans; Lung Neoplasms; Neoplasm Staging; Polymorphism, Genetic; Treatment outcome; X-ray Repair Cross Complementing Protein 1

Non-small cell lung cancer (NSCLC) is the most common cancer globally. The XRCC1 protein interacts with ligase and poly(ADP-ribose) polymerase to repair cisplatin-induced DNA damage. The authors of previous studies have reported XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms and advanced NSCLC prognosis, but the results are inconclusive. We investigated the association between ... more

H.F. Liu; J.S. Liu; J.H. Deng; R.R. Wu

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