Research Article

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07/14/2016
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Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as ... more

J.J. Liu; W. Wang; M. Meng; C.S. Liang; J.W. Zhang
07/14/2016
Meta-analysis; Monoamine oxidase B; Parkinson’s disease; Polymorphism

Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphism and PD. Eligible studies were identified via databases such as ... more

J.J. Liu; W. Wang; M. Meng; C.S. Liang; J.W. Zhang; J.J. Liu; W. Wang; M. Meng; C.S. Liang; J.W. Zhang
07/14/2016
Interleukin-6; Meta-analysis; Polymorphism; Psoriasis

Previous studies examining the association between interleukin-6 (IL-6) -174G/C polymorphism and psoriasis risk have produced inconsistent results. The aim of this study was to offer a comprehensive review of the association between IL-6 -174G/C polymorphism and psoriasis risk through a meta-analysis. Literature search of PubMed and Embase databases was conducted to identify all eligible ... more

G. Nie; C.L. Xie; Y.J. Cao; M.M. Xu; X. Shi; A.L. Zou; J.H. Qi; G. Nie; C.L. Xie; Y.J. Cao; M.M. Xu; X. Shi; A.L. Zou; J.H. Qi
06/24/2016
Chinese donkey; Microsatellite; Phylogenetic relationship; Polymorphism

To reveal the genetic diversity and phylogenetic relationships between Chinese donkey breeds, 415 individuals representing ten breeds were investigated using ten microsatellite markers. The observed number of alleles, mean effective number of alleles (NE), mean expected heterozygosity (HE), and polymorphic information content (PIC) of each breed and ... more

R.F. Zhang; W.M. Xie; T. Zhang; C.Z. Lei; R.F. Zhang; W.M. Xie; T. Zhang; C.Z. Lei
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Basigin gene; Esophageal cancer; miR-483-5p; Polymorphism

The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer patients and 636 cancer-free age- and gender-matched ... more

H.Y. Li; Y.C. Liu; Y.H. Bai; M. Sun; L. Wang; X.B. Zhang; B. Cai; H.Y. Li; Y.C. Liu; Y.H. Bai; M. Sun; L. Wang; X.B. Zhang; B. Cai
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Cerebral infarction; Mononucleotide; Polymorphism; PPAR gamma

The variant of PPAR-g2 has been shown to promote the increase of carotid IMT in patients suffering from cerebral infarction and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptorg2 (PPARg2) gene may be associated with cerebral infarction. However, due to the different genetic background, race, and regional variations of cerebral infarction ... more

X. Li; B.L. Zhang; X.G. Zhang; X.L. Su; X. Li; B.L. Zhang; X.G. Zhang; X.L. Su
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AMPD1; C34T; Essential hypertension; Malaysia; Polymorphism

The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted using a commercial kit from the whole blood of 200 patients with ... more

R. Nemati; J. Lu; V. Ramachandran; A. Etemad; M. Heidari; M.J. Yahya; R. Roozafzoon; P. Ismail; R. Nemati; J. Lu; V. Ramachandran; A. Etemad; M. Heidari; M.J. Yahya; R. Roozafzoon; P. Ismail
06/17/2016
Cytochrome P450; Lung cancer; Meta-analysis; Polymorphism; Risk

The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) ... more

J. Ren; B.Z. He; T.S. Zhang; S.P. Lu; T. Yan; J. Ren; B.Z. He; T.S. Zhang; S.P. Lu; T. Yan
06/16/2016
Coronary artery disease; Interleukin 6; Polymorphism

To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction fragment length polymorphism. Results ... more

L. Mao; G.Y. Geng; W.J. Han; M.H. Zhao; L. Wu; H.L. Liu; L. Mao; G.Y. Geng; W.J. Han; M.H. Zhao; L. Wu; H.L. Liu
06/16/2016
Breast cancer; GSTP1; Meta-analysis; Polymorphism

Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this meta-analysis was conducted to obtain a ... more

M. Kuang; W. Xu; C.X. Cao; L.L. Shen; J. Chang; X.L. Zhang; J.F. Chen; C.J. Tang; M. Kuang; W. Xu; C.X. Cao; L.L. Shen; J. Chang; X.L. Zhang; J.F. Chen; C.J. Tang

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