Research Article

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06/03/2016
Gestational diabetes mellitus; GSTM1; GSTP1 IIe105Val; GSTT1; Polymorphism

We investigate the role of the GSTM1, GSTT1, and GSTP1 IIe105Val genetic polymorphisms in the susceptibility to gestational diabetes mellitus. A total of 223 pregnant women with gestational diabetes mellitus and 265 healthy pregnant women were examined at The Second Affiliated Hospital of Shaanxi University of Chinese Medicine from May 2013 to November 2013. ... more

Y.H. Qiu; Y.L. Xu; W.H. Zhang; Y.H. Qiu; Y.L. Xu; W.H. Zhang
05/25/2016
CYP1A1; Estrogen receptor β; GSTM1; GSTT1; p53; Progesterone receptor

In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response ... more

K.S.F. Silva; K.K.V.O. Moura; K.S.F. Silva; K.K.V.O. Moura
01/29/2016
Colorectal carcinoma; GSTM1; Polymorphism

The enzyme glutathione S-transferase Mu 1 (GSTM1) is encoded by the GSTM1 gene. Polymorphisms in GSTM1 affect the detoxifying function of the enzyme variants. This forms the basis of the debate about the impact of the GSTM1 null/present genotype on colorectal carcinoma risk. We tested the potential influence of GSTM1 polymorphisms on the development of ... more

M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz; M.N. Khabaz; T. Nedjadi; M.A. Gari; J.A. Al-Maghrabi; H.M. Atta; M. Bakarman; Z.J. Gazzaz
05/20/2016
Janus kinase 2; Metastasis; MicroRNA-204; NSCLC

Aberrant expression of microRNA is associated with the development and progression of cancers. MicroRNA-204 (miR-204) down-regulation has been previously demonstrated in non-small-cell lung carcinoma (NSCLC); however, the underlying mechanism by which miR-204 suppresses tumorigenesis in NSCLC remains elusive. In this study, miR-204 expression was found to be down-regulated, and that of ... more

P. Wang; H.Y. Lv; D.M. Zhou; E.N. Zhang; P. Wang; H.Y. Lv; D.M. Zhou; E.N. Zhang
05/23/2016
Bladder cancer; Chemotherapy; ERCC1; Polymorphism

This study aims to investigate the association between ERCC1 codon C118T polymorphism and the response rate of platinum-based chemotherapy in patients with late-stage bladder cancer. A total of 41 eligible patients histologically confirmed as having stage IV muscle-invasive transitional cell carcinoma of the bladder were treated with platinum-based chemotherapy for 2-6 cycles. ... more

Z.C. Xu; H.Z. Cai; X. Li; W.Z. Xu; T. Xu; B. Yu; Q. Zou; L. Xu; Z.C. Xu; H.Z. Cai; X. Li; W.Z. Xu; T. Xu; B. Yu; Q. Zou; L. Xu
12/29/2015
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
02/25/2019
Cervical cancer; GSTM1; GSTT1; Smoking

Human papillomavirus infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in ... more

A.L.M. Tacca; A.K. Lopes; C.A.S.T. Vilanova-Costa; A.M.T.C. Silva; S.H.N. Costa; N.A. Nogueira; J.E.P. Ramos; A.A. Ribeiro; V.A. Saddi
02/25/2019
Atherosclerosis; eNOS; GSTM1; GSTT1; Hypertension

Atherosclerosis is a multifactorial chronic inflammatory disease that occurs in response to endothelial aggression. Systemic arterial hypertension is the main risk factor for the formation of atheromas, increasing the risk of cardiovascular diseases. Several genes are involved in atherogenesis and hypertension. We analyzed polymorphisms of candidate genes that ... more

M.P. Moraes; K.S.Fe Silva; M.H. Lagares; A.M. Barbosa; J.V.M. Martins; F.L. Campedelli; I.R. da Costa; D.A. Rodrigues; K.K.V.O. Moura
04/30/2019
GSTM1; GSTT1; Polymorphism; Prognosis; Sickle cell anemia

Sickle cell anemia is one of the most common genetic diseases in Brazil. This disease has an autosomal recessive inheritance pattern with a point mutation on chromosome 11, which is the substitution of an adenine by thymine. This mutation leads to the exchange of a glutamic acid for a valine at residue 6 of the beta globin chain, resulting in an abnormal form of hemoglobin, the so-called ... more

O.S.Dias Neto; K.S.Fe Silva; A.M. Barbosa; D.A. Rodrigues; M.H. Lagares; I.R. da Costa; K.K.V.O. Moura
07/31/2019
GSTM1; GSTT1; Polymorphism; Prostate cancer; Risk factor

Prostate cancer (PCa) is the second most common type of tumor among men over 50 years old and its etiology includes environmental, demographic, and genetic risk factors. We investigated a possible association between GSTM1 and GSTT1 polymorphisms, sociodemographic, and clinical factors with PCa in a population of southwestern Bahia, Brazil. The ... more

L.C.F. de Souza; T.L.S. Brito; A.T. Almeida; Y.P. Muniz; P.B. Nishiyama; C.L. Souza; L. Tomazi

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