Research Article

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08/21/2015
C6 glioma cells; Cytokines; Midazolam

The current study was performed to investigate the effects of midazolam on immune function in pediatric patients after surgery and possible mechanism involved. Patients who needed sedation for more than 2 consecutive days after undergoing surgery in the Pediatric Surgery Department of our hospital were enrolled for the study. Fifty-six patients (5-14 years old) were randomly divided into ... more

H.B. Lu; Y.P. Jia; Z.H. Liang; R. Zhou; J.Q. Zheng
07/17/2015
Cytokines; HaCaT cells; Irradiation; Th cells

We have previously found that an imbalance of Tc1/Tc2 T cell subtypes in vivo impacts the development of photodermatitis. The aim of this study was to investigate the relationship between cytokines derived from keratinocytes exposure to UV and the imbalance of Th subgroups. We used different doses of UVA and UVB to irradiate HaCaT cells. Twelve hours after irradiation, the ... more

H.Y. Li; F.R. Zhang; D.Q. Deng
12/09/2015
Cytokines; Flurbiprofen axetil; Immunosuppressive; Morphine; Tramadol

We explored the effects of flurbiprofen axetil on interleukin (IL)-2 and IL-6 levels in postoperative patients with colorectal cancer. A total of 120 patients (American Society of Anesthesiologists I and II) scheduled to undergo colorectal cancer surgery were randomly divided into 3 groups (N = 40 in each group): flurbiprofen axetil group (group F), morphine group (group M), and tramadol ... more

W.W. Jiang; Q.H. Wang; P. Peng; Y.J. Liao; H.X. Duan; M. Xu; Y. Li; P.B. Zhang
2/16/2017
Alzheimer disease; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Maze Learning; Mice; MicroRNAs; Receptor, Cannabinoid, CB2

Alzheimer's disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as well as the learning and memory function in AD. We observed that the miR-139 ... more

Y. Tang; J.S. Bao; J.H. Su; W. Huang
3/8/2017
Adult; Aged; Cytokines; Endothelial cells; Female; Fibroblasts; Humans; Macrophages; male; Mast Cells; Middle Aged; Periapical Diseases; Periapical Granuloma; Periapical Tissue; Radicular Cyst; Stem Cell Factor

Stem cell factor (SCF), an important stem cell cytokine, has multiple functions. Fibroblasts (FBs), mature mast cells, endothelial cells (ECs), and eosinophil granulocytes can produce SCF in the inflammatory process. Therefore, we aimed to observe SCF expression in FBs, ECs, and macrophages (MPs) in periapical tissues in human chronic periapical disease and investigate the effects of cells ... more

S.Q. Shen; R. Wang; S.G. Huang
3/16/2017
Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Female; Humans; Interferon-gamma; Interleukin-10; Interleukin-4; male; Prognosis; Severity of Illness Index; Spondylitis, Ankylosing; Th1 Cells; Th2 cells; Tumor necrosis factor-alpha; Young Adult

Ankylosing spondylitis (AS), a progressive disease of the spine, manifests as peripheral arthritis with tendon and ligament inflammation that restricts activity. AS is a rheumatoid autoimmune disease although the rheumatoid factor is absent in patients with AS. It is characterized by inflammatory changes such as elevated levels of serum inflammatory factors. The roles of Th1 and Th2 cytokines ... more

J.T. Wen; D.H. Zhang; P.F. Fang; M.H. Li; R.J. Wang; S.H. Li
3/16/2017
Alendronate; Animals; Bone Density Conservation Agents; Bone morphogenetic protein 2; Cytokines; Disease Models, Animal; Dyskinesias; Female; Fibroblast Growth Factor 2; Humans; Insulin-like growth factor I; Osteoporosis; Ovariectomy; Rabbits; Treatment outcome; Up-Regulation

Alendronate regulates the activity of osteoclasts and healing of osteoporosis. This study investigated the effect of alendronate on bone healing and changes in the levels of cytokines. Bilateral ovaries of 10 adult female rabbits were removed surgically in aseptic condition to establish the animal model of osteoporosis. Five rabbits in group A were treated with alendronate (1.15 mg·kg·week) ... more

C.T. Liu; X.J. Yuan; G.C. Gao
12/29/2015
Biomarker; Diagnosis; Ewing's sarcoma; miR-125; Serum

Previous studies indicated that microRNA-125b (miR-125b) has an important role in the progression of Ewing’s sarcoma (ES). The purpose of the current study was to examine expression changes of miR-125b in the serum of ES patients and evaluate if the expression level of miR-125b could serve as a new biomarker for ES. This study was performed on patients who underwent surgical resection at ... more

C.L. Nie; W.H. Ren; Y. Ma; J.S. Xi; B. Han
12/07/2015
Gastric cancer; miR-200c; Prognostic biomarker; Serum

The aim of the present study was to analyze the serum expression level of microRNA-200c (miR-200c) in gastric cancer (GC) patients and to determine the relationship between this expression and clinicopathological features and survival. Serum samples were obtained from 98 patients with GC between February 2008 and January 2013. Quantitative RT-PCR was used to assess miR-200c expression levels ... more

H.P. Zhang; F.B. Sun; S.J. Li
05/27/2020
meningiomas; MicroRNAs; Serum

Meningiomas are the most common primary tumors of the central nervous system, accounting for 35.5% of cases, considering all age groups. Despite progress made in recent decades, tumorigenesis of meningiomas still remains a challenge. There is a consensus of a need for molecular tools to assist in diagnosis and prognosis of meningiomas. In this context, some studies ... more

M.S.T. Rosa; F. Pansani; F.O. Buono; M.F.B.M. Tiezzi; L.P. Turra; F.S.Lizarte Neto; P.C. Novais; M.F.G.S. Tazima; F.M. Peria; V.M. Carneiro; M.L.A. Cirino; L.F. Tirapelli; B.O. Colli; C.G.Carlotti Junior; D.P.C. Tirapelli

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