Research Article

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The critical role of ATP-binding cassette B1 (ABCB1) in the function of the blood-brain barrier led us to conducted this prospective study in order to investigate the clinical outcome of patients suffering from severe traumatic brain injury. A total of 182 patients with traumatic brain injury were included in our study. Genotyping of ABCB1 C3435T and G2677T/A was conducted using ... more

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Hyperbaric oxygen; Nrf2; Traumatic brain injury

We investigated the effects of hyperbaric oxygen treatment on the Nrf2 signaling pathway in secondary injury following traumatic brain injury, using a rat model. An improved Feeney freefall method was used to establish the rat traumatic brain injury model. Sixty rats were randomly divided into three groups: a sham surgery group, a traumatic brain injury group, and a group receiving ... more

X.E. Meng; Y. Zhang; N. Li; D.F. Fan; C. Yang; H. Li; D.Z. Guo; S.Y. Pan; X.E. Meng; Y. Zhang; N. Li; D.F. Fan; C. Yang; H. Li; D.Z. Guo; S.Y. Pan; X.E. Meng; Y. Zhang; N. Li; D.F. Fan; C. Yang; H. Li; D.Z. Guo; S.Y. Pan
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Diabetes; Insulin resistance; Visceral adipose tissue-derived serpin

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Gestational diabetes mellitus; Insulin resistance; Lipoprotein lipase gene polymorphism

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Association study; Candidate genes; Insulin resistance; Quantitative traits; Type 2 diabetes mellitus

Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single nucleotide polymorphisms (SNPs) and metabolic syndrome-related ... more

F.J. Wei; C.Y. Cai; P. Yu; J. Lv; C. Ling; W.T. Shi; H.X. Jiao; B.C. Chang; F.H. Yang; Y. Tian; M.S. Li; Y.H. Wang; L. Zou; J.M. Shi; L.M. Chen; W.D. Li
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Childhood obesity is a serious public health concern condition, as excess body fat can negatively affect a child's health. Obestatin is a hormone that regulates body weight by suppressing appetite and reducing food intake; fasting obestatin level is negatively correlated with basal insulin level. This study aims to investigate the role of obestatin in insulin resistance. A total of 54 children ... more

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Endothelial Dysfunction; Exercise Intervention; Impaired Glucose Tolerance; Insulin resistance; Prediabetes Mellitus; Vascular Endothelium
Prediabetes is considered to be an at a risk state, with
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patients in 2030. The elevation of blood sugar is a continuum and
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