Research Article

Related GMR Articles

09/21/2015

Effect of single nucleotide polymorphisms in the ATP-binding cassette B1 gene on the clini­cal outcome of traumatic brain injury

ATP-binding cassette B1 gene; Clinical outcome; Traumatic brain injury

The critical role of ATP-binding cassette B1 (ABCB1) in the function of the blood-brain barrier led us to conducted this prospective study in order to investigate the clinical outcome of patients suffering from severe traumatic brain injury. A total of 182 patients with traumatic brain injury were included in our study. Genotyping of ABCB1 C3435T and G2677T/A was conducted using ... more

Z.L. Wang; D.S. Xu; Y.X. Wang; H. Qin; D. Geng
01/29/2016

Effects of hyperbaric oxygen on the Nrf2 signaling pathway in secondary injury following traumatic brain injury

Hyperbaric oxygen; Nrf2; Traumatic brain injury

We investigated the effects of hyperbaric oxygen treatment on the Nrf2 signaling pathway in secondary injury following traumatic brain injury, using a rat model. An improved Feeney freefall method was used to establish the rat traumatic brain injury model. Sixty rats were randomly divided into three groups: a sham surgery group, a traumatic brain injury group, and a group receiving ... more

X.E. Meng; Y. Zhang; N. Li; D.F. Fan; C. Yang; H. Li; D.Z. Guo; S.Y. Pan; X.E. Meng; Y. Zhang; N. Li; D.F. Fan; C. Yang; H. Li; D.Z. Guo; S.Y. Pan; X.E. Meng; Y. Zhang; N. Li; D.F. Fan; C. Yang; H. Li; D.Z. Guo; S.Y. Pan
09/25/2015

Changes and clinical significance of serum vaspin levels in patients with type 2 diabetes

Diabetes; Insulin resistance; Visceral adipose tissue-derived serpin

We investigated serum visceral adipose tissue-derived serpin (vaspin) levels in patients with normal glucose regulation and recently diagnosed type 2 diabetes (T2DM) and explored the association between vaspin and body mass index, age, gender, glucose, lipid metabolism, and insulin sensitivity. Fasting serum vaspin levels in 66 patients with T2DM and 48 normal subjects were detected using ... more

L. Yang; S.J. Chen; G.Y. Yuan; D. Wang; J.J. Chen
07/14/2015

Relationship between a lipoprotein lipase gene polymorphism in placental tissue and insulin resistance in patients with gestational diabetes mellitus

Gestational diabetes mellitus; Insulin resistance; Lipoprotein lipase gene polymorphism

The aim of this study was to investigate the relationship between a lipoprotein lipase (LPL) gene polymorphism in placental tissue and insulin resistance (IR) in patients with gestational diabetes mellitus. Using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) analysis, the LPL HindIII RFLP was examined in the placental tissue of 110 ... more

D.D. Li; D.Y. Su; L. Xue; W. Gao; W.Y. Pang
12/01/2015

Quantitative candidate gene association studies of metabolic traits in Han Chinese type 2 diabetes patients

Association study; Candidate genes; Insulin resistance; Quantitative traits; Type 2 diabetes mellitus

Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single nucleotide polymorphisms (SNPs) and metabolic syndrome-related ... more

F.J. Wei; C.Y. Cai; P. Yu; J. Lv; C. Ling; W.T. Shi; H.X. Jiao; B.C. Chang; F.H. Yang; Y. Tian; M.S. Li; Y.H. Wang; L. Zou; J.M. Shi; L.M. Chen; W.D. Li
4/28/2017

Correlation analysis of serum obestatin expression with insulin resistance in childhood obesity.

Adolescent; Blood glucose; Case-control studies; Child; Female; Ghrelin; Humans; Insulin resistance; Lipoproteins; male; Obesity; Triglycerides

Childhood obesity is a serious public health concern condition, as excess body fat can negatively affect a child's health. Obestatin is a hormone that regulates body weight by suppressing appetite and reducing food intake; fasting obestatin level is negatively correlated with basal insulin level. This study aims to investigate the role of obestatin in insulin resistance. A total of 54 children ... more

M.Y. Zhang; F. Li; J.P. Wang
11/29/2017

Improvement of Exercise Intervention on Vascular Endothelial Functions during Prediabetes Mellitus

Endothelial Dysfunction; Exercise Intervention; Impaired Glucose Tolerance; Insulin resistance; Prediabetes Mellitus; Vascular Endothelium
Prediabetes is considered to be an at a risk state, with
an annualized 5-10% conversion rate of diabetes and the similiar
proportion converting back to normoglycaemia. The global
incidence of prediabetes is increasing and will reach to 471 million
patients in 2030. The elevation of blood sugar is a continuum and
hence prediabetes cannot ... more
S. Wang; Z. Zhang; Y. Liu; Z. Wang