Related GMR Articles

Elderly; FII G20210A; FV G1691A; Genetic polymorphisms; MTHFR C677T; Venous thromboembolism

Venous thromboembolism (VTE) is an important cause of morbidity and mortality stemming from cardiovascular disease. It is a multifactorial disease caused by a combination of acquired risk factors, of which advanced age is the most significant, and genetic factors, including the variants FV G1691A, FII G20210A, and MTHFR C677T. We estimated the prevalence of ... more

H. Ferreira-Fernandes; P.N. Costa; H.F. Fernandes; A.P. Araújo-Neto; F.J. Motta; R. Canalle; F.K. Yoshioka; J.F. Guerreiro; R.R. Burbano; J.A. Rey; G.R. Pinto
Genetics; GWAS; Hypertension; NPR3; Population diversity

Hypertension affects one-fifth of the world population. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that correlated with hyper­tension in large samples. However, the genetic mutations leading to hypertension might differ among various populations, as they have dif­ferent origins and are subjected to different environmental ... more

H. Sun; Z.Q. Yang; S.Y. Liu; L. Yu; K. Huang; K.Q. Lin; J.Y. Chu; X.Q. Huang
Genetics; Hepatocellular carcinoma; KRAS; Polymorphisms

KRAS, also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, acts as an intracellular signal transducer. The oncogenic KRAS mutation is an essential step in the development of many types of human cancers, including hepatocellular carcinoma. Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carcinoma ... more

D. Xiong; Y.P. Song; W. Xiong; Y.D. Liang
Adolescent; Genetics; Idiopathic; Muscle; Polymorphism; Scoliosis

Several theories have been proposed to explain the etiology of adolescent idiopathic scoliosis (AIS), but none is conclusive. One such theory suggests the primary involvement of muscles due to myopathy, mainly affecting the erector and paravertebral rotator muscles. Studies indicate that there may be an association of AIS with genetic polymorphisms previously ... more

M. Wajchenberg; D.E. Martins; R.P. Luciano; R.C. Araujo; B. Schmidt; A.B.S. Oliveira; E.B. Puertas; S.S. Almeida; F. Faloppa
Cotton; Disease; DNA; Fusarium; Mexicali valley

Cotton production in the Mexicali valley is adversely affected by wilt and root rot disease associated with Fusarium species. In the present study, we sought to isolate and identify the Fusarium species in the rhizosphere of transgenic insect-resistant cotton plants grown in the Mexicali valley. Our analyses isolated four native fungi from the rhizosphere of cotton ... more

T. Gonzalez-Soto; D. González-Mendoza; R. Troncoso-Rojas; A. Morales-Trejo; C. Cecena-Duran; A. Garcia-Lopez; O. Grimaldo-Juarez
Alleles; Animals; Brazil; Breeding; Chromosome Mapping; DNA; Genetic Drift; Genetic variation; Genetics, Population; Genotype; Goats; Heterozygote; Microsatellite Repeats

The aim of this study was to access the genetic diversity and relatedness between Canindé and British Alpine goat breeds in the States of Piauí and Ceará using microsatellite markers. Genomic DNA was isolated from hair samples of 99 goats belonging to six different flocks. A panel of polymorphic heterologous microsatellite loci was used to genotype individuals. The microsatellite markers ... more

T.S. Câmara; J.F. Nunes; F.M. Diniz; G.R. Silva; A.M. Araújo
Alleles; DNA; DNA Primers; Forensic genetics; Gene frequency; Genetics, Population; Humans; Microsatellite Repeats; Molecular Diagnostic Techniques; Multiplex polymerase chain reaction; Polymorphism, Genetic

This study aimed to develop a short tandem repeat (STR) multiplex system, made up of 22 highly informative STR loci, for application in forensic genetics. The system comprised 21 polymorphic autosomal loci (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX, FGA, D2S441, D17S1301, D19S433, D18S853, D20S482, and D14S1434) and the ... more

R.G. Rodovalho; E.L. Rodrigues; G.S. Santos; L.M. Cavalcanti; P.R. Lima; A.G. Rodovalho; R.G. Vital; M.A.D. Gigonzac; A.D. da Cruz
Base Composition; DNA; Fibroins; Inverted Repeat Sequences; Nucleic Acid Denaturation; Polymerase chain reaction; Repetitive Sequences, Amino Acid

Although PCR-based techniques have become an essential tool in the field of molecular and genetic research, the amplification of repetitive DNA sequences is limited. This is due to the truncated nature of the amplified sequences, which are also prone to errors during DNA polymerase-based amplification. The complex structure of repetitive DNA can form hairpin loops, which promote dissociation ... more

J. Riet; L.R.V. Ramos; R.V. Lewis; L.F. Marins
DNA; miRNA; mRNA; Next-generation sequencing; Phalaenopsis; PhalDB

The orchid family Orchidaceae is one of the largest families of angiosperms; it includes approximately 35,000 species, displays a wide range of unique flower shapes and is a valued ornamental crop. Among the various species of orchids, the Phalaenopsis genus is the most widely commercialized among blooming potted plants. Our aim was to provide in-depth ... more

C.Y. Lee; K.K. Viswanath; J.Z. Huang; C.P. Lee; C.P. Lin; T.C. Cheng; B.C. Chang; S.W. Chin; F.C. Chen
barcodes; Desert plant; DNA; ITS2; matK; rbcL

Many of the plants that grow in arid and semi-arid regions under harsh conditions (drought, salinity and misuse) are of medical importance. Desert plants also provide other benefits; so conservation efforts should be strengthened in these areas. In this study, three DNA barcodes – chloroplast maturase-K (matK), ribulose-1,5-bisphosphate carboxylase/oxygenase (rbcL ... more

W.S. Al-Juhani