Research Article

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01/08/2016
Chronic lymphocytic leukemia; Differentially expressed genes; MicroRNA; Module analysis

Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL samples and age-matched controls were ... more

L. Dong; K.H. Bi; N. Huang; C.Y. Chen; L. Dong; K.H. Bi; N. Huang; C.Y. Chen; L. Dong; K.H. Bi; N. Huang; C.Y. Chen
2017 Feb 23
Apoptosis; Blotting, Western; Breast neoplasms; Cell Line, Tumor; Cell Movement; Cell proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Down-regulation; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; MCF-7 cells; MicroRNAs; Microscopy, Electron; Neoplasm Invasiveness; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; Transcription factors

Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered that miR-660-5p was upregulated in the breast cancer cell lines ... more

Y. Shen; Y.F. Ye; L.W. Ruan; L. Bao; M.W. Wu; Y. Zhou
07/03/2015
Diagnosis; Meta-analysis; MicroRNAs; Thyroid cancer

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive ... more

G.J. Zhou; M. Xiao; L.N. Zhao; J.G. Tang; L. Zhang
12/11/2015
Head and neck cancer; Meta-analysis; MicroRNAs; Screening

Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search for relevant studies up to August ... more

M. Zhang; L.J. Zhao; W.Q. Liang; Z.P. Mao
10/05/2015
Acute lymphoblastic leukemia; MicroRNAs; Microvesicles; Zinc finger protein genes

Microvesicles (MVs) are submicrometric membrane fragments that can “engulf” cytoplasmic contents such as microRNAs (miRNAs) from their cellular origin. The study of miRNAs carried within MVs might provide insights into the roles that miRNAs play in the underlying pathophysiologic processes of acute lymphoblastic leu­kemia (ALL). We identified numerous dysregulated MV miRNAs in patients ... more

L. Lu; X.M. Chen; H.M. Tao; W. Xiong; S.H. Jie; H.Y. Li
2016 Nov 21
Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Uterine cervical neoplasms

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A thiazolyl blue tetrazolium bromide assay, caspase-3 activity, and ... more

X.J. Lai; X.Y. Cheng; L.D. Hu
2016 Dec 19
Animals; Cell Line, Tumor; Cell Movement; Cell proliferation; Endoglin; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Thyroid Neoplasms

Thyroid cancer is the most common type of endocrine tumor. MicroRNAs (miRNAs) play a critical role in a variety of diseases, especially cancer occurrence and progression. However, the specific mechanism by which miRNAs trigger disease states has not been fully elucidated. This study aims to investigate the role of miR-27a in thyroid cancer cells. A wound healing assay was adopted to examine ... more

Y.L. Wang; W.G. Gong; Q.L. Yuan
2016 Dec 19
3' Untranslated Regions; Animals; Cell differentiation; Cell proliferation; Cells, Cultured; Down-regulation; Gene Expression Regulation, Developmental; Microfilament Proteins; MicroRNAs; Muscle development; Muscle Proteins; Myoblasts; Swine

MicroRNAs (miRNAs) play important roles in the development and biochemical functions of skeletal muscles. However, targeting of miRNAs to structural genes involved in Z-discs have not been investigated. Here, we describe a highly expressed miRNA, miR-432, in pig embryonic skeletal muscle, which appeared to target myozenin1 (MYOZ1), a protein involved in the muscular sarcomere microstructure. ... more

R.M. Ren; H. Liu; S.H. Zhao; J.H. Cao
2017 Jan 23
Apoptosis; Cell Line, Tumor; Cell proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; RNA interference; Uterine cervical neoplasms

Cervical carcinoma is a life-threatening illness posing considerable danger to women's health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence of miR-187 on the growth, proliferation, and apoptosis of SiHa cervical ... more

C.Y. He; J. Yang
2017 Feb 16
Alzheimer disease; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Maze Learning; Mice; MicroRNAs; Receptor, Cannabinoid, CB2

Alzheimer's disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as well as the learning and memory function in AD. We observed that the miR-139 ... more

Y. Tang; J.S. Bao; J.H. Su; W. Huang

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