Research Article

Related GMR Articles

Comparative study; Evolutionary rate; MicroRNA; Model species; Molecular evolution

MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression. In an attempt to gain insights into miRNAs at the macroevolutionary level, we performed a systematic analysis of miRNAs in six model organisms based on their evolutionary rates. First, we calculated their miRNA evolutionary rates, and found that they did not correlate with the complexity of the organisms. A ... more

X.F. Mao; Y.C. Cao; X.F. Mao; Y.C. Cao; X.F. Mao; Y.C. Cao
Apoptosis; Epilepsy; Hippocampus; MicroRNA; Status epilepticus

Epilepsy is one of the most frequent neurological disorders. Recently, the regulation of microRNAs was found to be associated with epilepsy, but the molecular mechanism by which microRNA influences epilepsy process remains to be unveiled and the development of microRNA-based therapy requires more intensive research. In this study, five microRNAs with potential relevance to epilepsy were ... more

L. Ren; R. Zhu; X. Li; L. Ren; R. Zhu; X. Li
Chronic lymphocytic leukemia; Differentially expressed genes; MicroRNA; Module analysis

Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL samples and age-matched controls were ... more

L. Dong; K.H. Bi; N. Huang; C.Y. Chen; L. Dong; K.H. Bi; N. Huang; C.Y. Chen; L. Dong; K.H. Bi; N. Huang; C.Y. Chen
Artificial bee colony; binding sites; Bioinformatics; Discrete optimization; Motif discovery

The great majority of biological sequences share significant similarity with other sequences as a result of evolutionary processes, and identifying these sequence similarities is one of the most challenging problems in bioinformatics. In this paper, we present a discrete artificial bee colony (ABC) algorithm, which is inspired by the intelligent foraging behavior of real honey bees, for ... more

D. Karaboga; S. Aslan; D. Karaboga; S. Aslan; D. Karaboga; S. Aslan
Arabidopsis thaliana; Gamma rays; Genetic marker; Microarray; MicroRNA; Transcriptome

MicroRNAs (miRNAs) regulate gene expression in response to biotic and abiotic stress in plants. We investigated gamma-ray-responsive miRNAs in Arabidopsis wild-type and cmt3-11t mutant plants using miRNA microarray analysis. miRNA expression was differentiated between the wild-type and cmt3-11t mutants. miR164a, miR169d, miR169h, miR172b*, and miR403 were ... more

J.H. Kim; Y.S. Go; J.K. Kim; B.Y. Chung; J.H. Kim; Y.S. Go; J.K. Kim; B.Y. Chung
Biomarker; Functional network; Heart disease; MicroRNA; Pathway

Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures distinguishing ICM/NICM from control samples. Furthermore, we ... more

X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han; X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han; X. Li; C.Y. Liu; Y.S. Li; J. Xu; D.G. Li; D. Han
CXCR4; EGFR2; Endometriosis; MicroRNA; PTEN; VEGFA

We examined the aberrant microRNA (miRNA) expression profile responsible for the changes in angiogenesis observed in endometriotic lesions. This study revealed characteristic miRNA expression profiles associated with endometriosis in endometrial tissue and endometriotic lesions from the same patient, and their correlation with the most important angiogenic and fibrinolytic factors. miRNA ... more

R.Q. Yang; H. Teng; X.H. Xu; S.Y. Liu; Y.H. Wang; F.J. Guo; X.J. Liu; R.Q. Yang; H. Teng; X.H. Xu; S.Y. Liu; Y.H. Wang; F.J. Guo; X.J. Liu
Beta vulgaris; Bioinformatics; EST; GSS; MicroRNA

Highly conserved endogenous non-coding microRNAs (miRNAs) play important roles in plants and animals by silencing genes via destruction or blocking of translation of homologous mRNA. Sugar beet, Beta vulgaris, is one of the most important sugar crops in China, with properties that include wide adaptability and strong tolerance to salinity and impoverished soils. Seedlings of ... more

J.L. Li; J. Cui; D.Y. Cheng
Bioinformatics; Clone; LOC339524 gene; Sprague-Dawley rat (Rattus norvegicus)

We cloned the LOC339524 gene in Sprague-Dawley (SD) rats and analyzed the structure and function of the protein encoded by it. Based on the known human LOC339524 gene sequences, the full-length coding sequence of the LOC339524 gene in SD rats was cloned and amplified by the polymerase chain reaction using the complementary DNA of SD rats as a template. Bioinformatics analysis showed that ... more

Z.H. Long; H. Li; F. Chen; L.Y. Zou
Bacteria; Bioinformatics; Fungi; Laccase; Oomycetes; Plant pathogen

To date, research on laccases has mostly been focused on plant and fungal laccases and their current use in biotechnological applications. In contrast, little is known about laccases from plant pathogens, although recent rapid progress in whole genome sequencing of an increasing number of organisms has facilitated their identification and ascertainment of their origins. In this study, a ... more

B.Z. Feng; P.Q. Li; L. Fu; X.M. Yu