Research Article

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04/26/2016
A1298C; C677T; Male infertility; Meta-analysis; MTHFR; Polymorphisms

Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of PubMed, EMBASE, the Cochrane Library, the Web of Science ... more

Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu; Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu; Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu
04/07/2016
A1298C; C677T; Lung cancer; Meta-analysis; MTHFR; Polymorphisms

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource ... more

Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu
06/03/2016
A1298C; MTHFR; Neural tube defects; Polymorphism

The etiology underlying neural tube defects (NTDs) is not fully understood and is believed to involve a complex milieu of genetic and environmental factors. The A1298C polymorphism in the methylenetetrahydropholate reductase gene (MTHFR) has been associated with mild risk for NTDs. In this study, the genotype distribution of the MTHFR gene A1298C polymorphism and the ... more

S.H. Yildiz; O. Erdogan; M. Solak; O. Eser; E.S.Arıkan Terzi; B. Eser; V. Kocabaş; A. Aslan; S.H. Yildiz; O. Erdogan; M. Solak; O. Eser; E.S.Arıkan Terzi; B. Eser; V. Kocabaş; A. Aslan
07/14/2016
Hypertension; Left ventricular hypertrophy; Receptor for advanced glycation end-products

Soluble receptor for advanced glycation end-products (sRAGE) acts as a decoy to prevent interaction between RAGE and its pro-inflammatory ligands. sRAGE levels have been found to decrease in chronic inflammatory diseases, including hypertension. However, few data have been reported concerning the association between serum sRAGE levels and hypertensive left ventricular hypertrophy (LVH). ... more

Q. Liu; H.B. Chen; M. Luo; H. Zheng; Q. Liu; H.B. Chen; M. Luo; H. Zheng
05/13/2016
Chinese family; Hypertension; mtDNA; Mutation

Mutations in the mitochondrial genome have been found to be associated with essential hypertension. Here, we report the clinical and molecular characterization of a three-generation Han Chinese family with maternally inherited hypertension. Most strikingly, this pedigree exhibited a high penetrance of hypertension. Sequence analysis of the mitochondrial genome showed the presence of a ... more

J.F. Zhu; X. Zhang; L. Ling; J.F. Zhu; X. Zhang; L. Ling
01/22/2016
Calcium/calmodulin-dependent kinase 4; CAMK4; Hypertension; rs10491334

Considering that calcium/calmodulin-dependent kinase 4 (CAMK4) plays a pivotal role in blood pressure regulation, we investigated the association between a CAMK4 polymorphism (rs10491334) and hypertension in the Han, Kazak, and Uygur ethnic groups. We studied 1224 patients with hypertension and 967 normotensive controls classified into three ethnic groups (Han, Kazak, and Uygur ... more

S.Z. Chen; Z. Wang; L.N. Zhang; G.L. Lu; C.M. Zhou; D.W. Wang; Z.M. Tang; L. Wang; L. Qin; Z.H. Zhai; S.Z. Chen; Z. Wang; L.N. Zhang; G.L. Lu; C.M. Zhou; D.W. Wang; Z.M. Tang; L. Wang; L. Qin; Z.H. Zhai; S.Z. Chen; Z. Wang; L.N. Zhang; G.L. Lu; C.M. Zhou; D.W. Wang; Z.M. Tang; L. Wang; L. Qin; Z.H. Zhai
07/27/2015
Chinese population; Familial aggregation; Gene polymorphism; Liver cancer; Risk factors; Transforming growth factor-β1

The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms in TGF ... more

P.Q. Wan; J.Z. Wu; L.Y. Huang; J.L. Wu; Y.H. Wei; Q.Y. Ning
2017 Feb 23
Adult; Asians; China; Female; Gene frequency; Genetic predisposition to disease; Genotype; Humans; Interleukin-10; Interleukin-6; Logistic Models; Odds Ratio; Polymerase chain reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pre-eclampsia; Pregnancy; Promoter Regions, Genetic; Risk factors; Young Adult

Preeclampsia is a common condition unique to pregnant women. Previous studies have suggested that several cytokines may contribute to defective placental invasion and endothelial damage in this condition. We investigated the influence of four single nucleotide polymorphisms (SNPs) in the promoters of IL-6 (-572G/C, -597G/A, and -174G/C) and IL-10 (-592A/C) on susceptibility to preeclampsia in ... more

D.M. Fan; Y. Wang; X.L. Liu; A. Zhang; Q. Xu
2017 Feb 23
Asians; China; Gene frequency; Genetic predisposition to disease; Genotype; Humans; Interleukin-1beta; Linkage disequilibrium; Odds Ratio; Periodontitis; Polymorphism, Single Nucleotide; Risk factors

The association between the interleukin-1 beta (IL-1β) C-511T (or rs16944) polymorphism and periodontitis remains inconclusive, even though there have been previous studies on this association. To assess the effects of IL-1β C-511T variants on the risk of development of periodontitis, a meta-analysis was performed in a single ethnic population. Studies, published up to December 2015, were ... more

H.F. Wang; F.Q. He; C.J. Xu; D.M. Li; X.J. Sun; Y.T. Chi; W. Guo
2/23/2017
Adolescent; Adult; Brazil; Cross-Sectional Studies; Cystathionine beta-Synthase; Epistasis, Genetic; Female; Folic acid; Gene frequency; Genetic predisposition to disease; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Linkage disequilibrium; male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk factors; Thrombophilia; Thrombosis; Vitamin B 12; Young Adult

High plasma homocysteine (Hcy) ​​levels may be responsible for vaso-occlusive episodes and may have acquired and/or genetic causes. This cross-sectional study aimed to investigate the role of methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C) and cystathionine-β-synthase (CBS; T833C/844ins68, G919A) polymorphisms in serum levels of folic acid, vitamin B12 and Hcy, and to verify a ... more

F.M. Amaral; A.L. Miranda-Vilela; G.S. Lordelo; I.F. Ribeiro; M.B. Daldegan; C.K. Grisolia

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