Research Article

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Amazon region; Cervical cancer; HPV; PCR

Infection by human papillomavirus (HPV) is one of the primary causes of mortality by cancer in northern Brazil. Sexually active women from Manaus, Amazonas, without cytological alterations and women with pre-malignant and malignant cytological alterations were examined for HPV virus, identified via PCR and sequencing. The target region for this study was part of the L1 capsid gene of HPV ... more

M.M. Castro; I.P. Farias; C.M. Borborema-Santos; G. Correia; S. Astolfi-Filho
Cervical cancer screening; Epidemiology; HPV; Human papillomavirus; Normal cytology; Risk factors

We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples of 399 women, received for routine evaluation in the Health ... more

P.M. Miranda; B.C.V. Pitol; M.S. Moran; N.N.T. Silva; P.M. Felix; J.L. Lima-Filho; C.M. Carneiro; I.D.C.G. Silva; R.F. Carvalho; A.A. Lima; W. Beçak; R.C. Stocco
Cervical precancerous lesion; HPV; miRNA-140; TLR4
Toll-like receptor 4 (TLR4), one of the key immune
system effectors, plays a main role in immune recognition of cervical
cancer. Micro-RNAs are involved in regulation of multiple important
genes in the progression of cervical cancer. A case-control study of
592 people was conducted from Yun’an County, Yunfu City,
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C. Huang; Z. Li; X. Zhong; Y. Wang; X. Ye; L. Jing; S. Huang; Q. Yin; Z. Miao; Z. Zhou; Y. Liu; X. Ye; Y. Han; M. Ou; D. Xiao; C. Guo; C. Zeng; G. Yang; C. Jing; X. Wei
Bone tumor; CYP1A1; Genetic susceptibility; Genotype; GSTM1

Tumor gene polymorphisms are often associated with individual susceptibility to genetic diseases. Cytochrome P4501A1 (CYP1A1) and glutathione S-transferase mu 1 (GSTM1) gene polymorphisms are closely related to the susceptibility of the body to chemical carcinogens in the environment. Therefore, we explored the relationship between CYP1A1 and GSTM1 gene ... more

L. Li; J.G. Li; C.Y. Liu; Y.J. Ding
Genotype; Hepatitis B virus; Sequence analysis

Hepatitis B virus genotype C (HBV/C) has the largest number of subgenotypes (C1-C16) that vary with geography and isolates. HBV/C prevails in Southeast Asia (C1, C5-C16), East Asia (C2), Oceania (C3), and Australia (C4). Suitable reference strains for different subgenotypes could greatly facilitate research into HBV/C, but unfortunately they are scarce. We retrieved 974 HBV/C full-length ... more

H.L. Zhu; C.T. Wang; J.B. Xia; X. Li; Z.H. Zhang
Genotype; Goat; Milk protein; Polymorphism; SDS-PAGE

This study evaluates the relationship between the genotype and milk protein components in goats. Milk samples were collected from cloned goats and normal white goats during different postpartum (or abortion) phases. Two cloned goats, originated from the same somatic line of goat mammary gland epithelial cells, and three sexually reproduced normal white goats with no genetic relationships ... more

H. Xing; B. Shao; Y.Y. Gu; Y.G. Yuan; T. Zhang; J. Zang; Y. Cheng
Adult; Alanine; Arginine; Asian People; Diabetes Mellitus, Type 2; Female; Genetic predisposition to disease; Genotype; Glutamine; Humans; Leucine; male; Middle Aged; Polymorphism, Single Nucleotide; Regression Analysis; Superoxide dismutase; Threonine

The most common type of endocrine disease is type 2 diabetes mellitus (T2DM); genetic factors contribute to the development to T2DM. In this study, we investigated the role of the Leu53Leu, Arg213Gly, and Ala40Thr polymorphisms in extracellular superoxide dismutase (EC-SOD) gene in the development of T2DM in a Chinese population. DNA was extracted from peripheral blood samples obtained from ... more

Y.M. Yang; X.R. Xie; A.L. Jin
Animals; Body weight; Cattle; Genome-wide association study; Genotype; Models, Biological; Phenotype; Polymorphism, Single Nucleotide; Quantitative trait loci

This study aimed to investigate the predictability of a phenotype when using a dynamic model of cattle growth. Genotypic and phenotypic information on Nellore (Bos indicus) cattle were used in a genome-wide association analysis designed to contrast the biological interpretation of core parameters [conversion efficiency of metabolizable energy to net energy for gain (k) and adjusted final ... more

M.C. Freua; M.H.A. Santana; R.V. Ventura; J.B.S. Ferraz
Animals; Avian Proteins; Chickens; Female; Genetic association studies; Genotype; Insulin-like growth factor I; Phenotype; Polymorphism, Single-Stranded Conformational; Quantitative trait loci; Reproduction; Selection, Genetic

The insulin-like growth factor, IGF-I, plays an important role in the development of growth and reproductive traits. Single-strand conformation polymorphism analysis was used to detect and analyze polymorphisms and expression profiles of the IGF-I gene and its association with growth and reproductive traits of Jinghai yellow chickens. A point mutation g.295T>C was detected in the IGF-I gene ... more

M.A. Abdalhag; T. Li; L. Duan; T. Zhang; G. Zhang; J. Wang; Y. Wang
Crosses, Genetic; Genotype; Phenotype; Quantitative trait loci; Zea mays

The successful development of hybrid cultivars depends on the reliability of estimated combining ability of the parent lines. The objectives of this study were to assess the combining ability of partially inbred S families of popcorn derived from the open-pollinated variety UENF 14, via top-crosses with four testers, and to compare the testers for their ability to discriminate the S progenies ... more

V.J. de Lima; A.T. do Amara Junior; S.H. Kamphorst; G.F. Pena; J.T. Leite; K.F.M. Schmitt; C. Vittorazzi; J.E. de Almei Filho; F. Mora