Research Article

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4/20/2017
Adolescent; Adult; Alleles; Case-control studies; China; Female; Genotype; Humans; Interleukin-6; Keloid; male; Middle Aged; Polymorphism, Single Nucleotide

The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay (ELISA). Results indicated ... more

X.J. Zhu; W.Z. Li; H. Li; C.Q. Fu; J. Liu
4/20/2017
Antineoplastic Agents; Biomarkers, Tumor; Female; Fusion Proteins, bcr-abl; Humans; Imatinib mesylate; Leukemia, Myeloid, Chronic-Phase; Leukocyte Count; male; Middle Aged; Platelet count; RNA, Messenger

In chronic myeloid leukemia (CML) two main types of messenger RNA (e14a2 and e13a2) can be produced by BCR-ABL1 gene rearrangement. Due to conflicting results, the clinical value of these transcripts remains controversial. The aim of this study was to identify associations of e14a2 and e13a2 transcripts with laboratory variables and also the response to treatment. This study included 203 adult ... more

A.P. Vasconcelos; I.F. Azevedo; F.C.B.C. Melo; W.B. Neves; A.C.A.C. Azevedo; R.A.M. Melo
4/28/2017
Biomarkers, Tumor; Carcinoma, Signet Ring Cell; CDX2 Transcription Factor; Codon; Female; Genes, ras; Humans; male; Middle Aged; Mucins; Mutation; Mutation Rate; Neoplasm Metastasis; Phenotype; Stomach neoplasms

We aimed to analyze gastric signet ring cell (SRC) carcinoma subtypes by investigating gastric and intestinal phenotypic marker expression, and explore the relationship between phenotype and K-ras mutation. Immunohistochemistry was performed on 163 SRC carcinoma patient specimens to detect gastric (MUC1, MUC5AC, and MUC6) and intestinal (MUC2 and CDX2) phenotypic markers, and tumors were ... more

Z.F. Xiong; J. Shi; Z.H. Fu; H.P. Wan; L.X. Tu
4/28/2017
Adolescent; Blood glucose; Case-control studies; Child; Female; Ghrelin; Humans; Insulin resistance; Lipoproteins; male; Obesity; Triglycerides

Childhood obesity is a serious public health concern condition, as excess body fat can negatively affect a child's health. Obestatin is a hormone that regulates body weight by suppressing appetite and reducing food intake; fasting obestatin level is negatively correlated with basal insulin level. This study aims to investigate the role of obestatin in insulin resistance. A total of 54 children ... more

M.Y. Zhang; F. Li; J.P. Wang
4/28/2017
Chromosomes, Human, Y; Databases, Nucleic Acid; Forensic genetics; Haplotypes; Humans; male; Microsatellite Repeats; Polymerase chain reaction

The use of Y chromosome haplotypes, important for the detection of sexual crimes in forensics, has gained prominence with the use of databases that incorporate these genetic profiles in their system. Here, we optimized and validated an amplification protocol for Y chromosome profile retrieval in reference samples using lesser materials than those in commercial kits. FTA cards (Flinders ... more

C.A. Souza; T.C. Oliveira; S. Crovella; S.M. Santos; K.C.N. Rabêlo; E.P. Soriano; M.V.D. Carvalho; A.F.Caldas Junior; G.G. Porto; R.I.C. Campello; A.A. Antunes; R.A. Queiroz; S.M. Souza
5/04/2017
Atherosclerosis; Case-control studies; Female; Genotype; Heterozygote; Humans; male; Middle Aged; Mutation, Missense; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide

Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alterations in the matrix, with consequent formation of the atheromatous ... more

F.L. Campedelli; K.S.F.E. Silva; D.A. Rodrigues; J.V.M. Martins; I.R. Costa; M.H. Lagares; A.M. Barbosa; M.P. de Morais; K.K.V.O. Moura
05/10/2017
Amino Acid Transport System y+L; Brain Neoplasms; Case-control studies; China; Female; Fusion Regulatory Protein 1, Light Chains; Glioma; Humans; male; Middle Aged; Polymorphism, Single Nucleotide

Gliomas are brain tumors that can be seriously damaging to human health. The SLC7 family is involved in amino acid or peptide transportation. The relationship between SLC7A7 polymorphisms and the development of glioma has been reported previously by a few studies. Therefore, we performed a hospital based case-control study to investigate the association of three common SNPs (rs12888930, ... more

H. Zhang; W.J. Shi
05/10/2017
Aged; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulins; male; Middle Aged; Neoplasm Metastasis; RNA, Messenger; Up-Regulation

The mRNA expression of cell adhesion molecule 1 (CADM1) and its clinicopathological significance in esophageal squamous cell carcinoma (ESCC) tissues were investigated. CADM1 mRNA and protein expression were detected in tissue samples from 50 patients with ESCC by reverse transcription-polymerase chain reaction (RT-PCR) and streptavidin-peroxidase (SP) immunohistochemistry; adjacent tissues ... more

J.B. Qian; H.B. Liu; Y. Zhu; F. Lu; Q.C. Yang; Y. Shen
05/10/2017
Animals; Brazil; Cats; Feline Acquired Immunodeficiency Syndrome; Female; Immunodeficiency Virus, Feline; Leukemia Virus, Feline; Leukemia, Feline; male; Pets

Our aims were to determine the frequencies of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) in owned and stray cats in the northeastern region of Brazil, ascertain the status of FeLV infection, and investigate potential associated factors among the owned cats. Blood samples from 200 asymptomatic owned cats and 30 stray cats were processed using nested PCR and commercial ... more

L.C. Lacerda; A.N. Silva; J.S. Freitas; R.D.S. Cruz; R.A. Said; A.D. Munhoz
05/18/2017
Adult; Arsenic; Arsenic Poisoning; Case-control studies; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; Drinking Water; Female; Humans; male; Mexico

Different studies have suggested an association between arsenic (As) exposure and damage to single-stranded DNA by reactive oxygen species derived from the biotransformation of arsenic. The single strand damages are converted to double strand damage upon interaction with ultraviolet radiation. Analysis of genomic integrity is important for assessing the genotoxicity caused by environmental ... more

J. Jiménez-Villarreal; D.I. Rivas-Armendáriz; C.P. Pineda-Belmontes; N.D. Betancourt-Martínez; M.A. Macías-Corral; A.J. Guerra-Alanis; M.S. Niño-Castañeda; J. Morán-Martínez

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