Research Article

Related GMR Articles

10/21/2015
Adenocarcinoma; D5F3 antibody; Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase; Epidermal growth factor receptor; Non-small cell lung cancer

Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene rearrangements and epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) have been intensively studied. The objective of this study was to determine the clinicopathological characteristics in genotype-specific subsets of patients with NSCLC to ... more

L. Xu; J. Lei; Q.Z. Wang; J. Li; L. Wu
08/10/2015
Breast cancer; S-phase kinase-associated protein 2; siRNA interference; SKP2

We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2 in breast cancer patient ... more

Y.J. Sun; X.K. Wang; B.J. Li
02/28/2024
Breast cancer; Circulating tumor cell; Gene expression; Vimentin

Globally, breast cancer a common disease affecting women. The epithelial cells lose their characteristic features and gain mesenchymal properties during disease progression. During transition, the intermediate filament changes status from keratin to cell-adhesive molecules. Vimentin, a glycoprotein constitutes an intermediate filament of mesenchymal cells to ... more

A.K. Saxena; Shalini; V. Singh; P. Singh
09/01/2015
Circulating tumor cells; Lung cancer; Non-small cell lung cancer

We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease patients were taken as a control ... more

Y.H. Xu; J. Zhou; X.F. Pan
08/28/2015
Concurrent chemoradiotherapy; Cytokine-induced killer cells; Dendritic cells; Non-small cell lung cancer

To compare the efficacy of dendritic and cytokine-induced killer cells (DC-CIK) therapy combined with concurrent radiochemotherapy on stage IIIB non-small cell lung cancer. Sixty-three patients with stage IIIB non-small cell lung cancer were randomly divided into the study and control groups. The study group, comprising 30 patients, was treated with DC-CIK combined with docetaxel- ... more

X.P. Zhu; Y.H. Xu; J. Zhou; X.F. Pan
08/21/2015
Microwave ablation; Non-small cell lung cancer; Vascular endothelial growth factor

We aimed to analyze the changes of serum vascular endothelial growth factor (VEGF) before and after microwave ablation (MWA) in patients with stage IIIB-IV non-small cell lung cancer (NSCLC), and to observe the effects of MWA combined with chemotherapy on short-term therapeutic efficacy and long-term survival. Concentrations of serum VEGF in 20 healthy subjects were considered as controls ... more

Y.H. Sun; P.Y. Song; Y. Guo; M. Pang; W.N. He; W.H. Zhang; L.J. Sheng
08/19/2015
EGFR gene promoter; Epidermal growth factor receptor; Methylation; Non-small cell lung cancer

We investigated the methylation state of the epidermal growth factor receptor (EGFR) gene promoter in non-small cell lung cancer (NSCLC) and analyzed its effect on tumor biology. We enrolled 120 patients with NSCLC who had been confirmed by pathologic diagnosis and had been operated on. The methylation states of the EGFR gene promoter were detected and analyzed and a prognosis was given. ... more

Z.Y. Pan; Z.S. Jiang; H.Q. Ouyang
01/04/2016
CYP1 A1; Gene polymorphism; Non-small cell lung cancer; Smoking

Many studies have shown that genetic factors, environmental factors, and bad living habits, especially smoking, are risk factors for lung cancer. However, not all smokers develop lung cancer, which may be related to different genetic backgrounds. Currently, most research has investigated the GSTM1, XRCC1, XRCC3, CYP2D6, and C188T genes. Little ... more

Y.Q. Xie; J.M. Chen; Y. Liu
12/22/2015
CXCR4; Meta-analysis; Non-small cell lung cancer; Protein expression

The specific correlation between CXCR4 expression and survival in non-small cell lung cancer (NSCLC) has been investigated independently; however, these have yielded inconsistent results. Therefore, we examined the exact relationship between CXCR4 expression and NSCLC in this meta-analysis. The bibliographic databases in English and Chinese were carefully searched and data regarding the ... more

H. Wang; F. Xie; Z. Hu; L. Chen
11/25/2015
CK19 mRNA; KS1/4 mRNA; LUNX mRNA; Micrometastases; Non-small cell lung cancer; RT-PCR

The expression of CK19, LUNX, and KS1/4 mRNA biomarkers was detected in the peripheral blood of non-small cell lung cancer (NSCLC) patients to investigate the feasibility of indicating lung cancer micrometastases. Micrometastases were identified in the peripheral blood of 32 NSCLC patients, 15 benign pulmonary disease (BPD) patients, and 10 healthy volunteers by ... more

L. Yan; Y. Yao; L.H. Wang; M.L. Wang; X.H. Fu

Pages