Research Article

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07/13/2015
Insulin-like growth factors; Osteoporosis; Polymorphism

We conducted a case-control study to assess the relation­ship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with osteoporosis were more likely to ... more

W. Zhang; L.C. Zhang; H. Chen; P.F. Tang; L.H. Zhang
07/13/2015
Polymorphism; Renal cell carcinomas; Vascular endothelial growth factor

We conducted a case-control study in a Chinese population to assess whether 5 common single-nucleotide polymor­phisms in the vascular endothelial growth factor gene (VEGF) affect the risk of renal cell carcinoma (RCC). The study population in­cluded 266 RCC patients who were newly diagnosed and histologi­cally confirmed to have RCC as well as 532 cancer-free controls. Genotyping ... more

W. Xian; H. Zheng; W.J. Wu
12/29/2015
Meta-analysis; Polymorphism; Prostate cancer

Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independently by two investigators. Pooled ... more

H.S. Zhu; J.F. Zhang; J.D. Zhou; M.J. Zhang; H.X. Hu
12/29/2015
Early-onset preeclampsia; Interleukin-10; Polymorphism

In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in ... more

Q.Y. Liu; F.Y. Gao; X.R. Liu; J. Li; M. Ji; J. Dong; X.T. Wang
12/29/2015
Association study; Polymorphism; RAGE; susceptibility; Ulcerative colitis

Ulcerative colitis (UC) is an immune-related disease with genetic predisposition. The aim of this study was to investigate the association of three polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with UC risk in a Chinese population. This case-control study involved 72 UC patients and 479 age- and gender-matched healthy controls. Genotyping was ... more

Z.T. Wang; L.Y. Wang; L. Wang; S. Cheng; R. Fan; J. Zhou; J. Zhong
12/29/2015
Interleukin-10; Meta-analysis; Nasopharyngeal carcinoma; Polymorphism; Promoter genes

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort ... more

Y.F. Yu; Z.G. Han; W.B. Guo; G.J. Zhang; J.K. Yang; F.L. Wu; Q.Y. Ou; Y.H. Li; X.Y. Cai; Z.N. Zhan; J.H. Chen; W.L. Xie; L. Tang; C.D. Liu
12/29/2015
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
12/29/2015
Cardiovascular disease; Coronary artery disease; Gene; Meta-analysis; Polymorphism; PPARγ2

This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of ... more

Y. Li; J. Zhu; J.Q. Ding
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Benign prostatic hyperplasia; Lymphotoxin beta receptor; Polymorphism; Prostate

The lymphotoxin-β receptor (LTβR) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LTβR and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 ( ... more

S.H. Lee; S.K. Kim; K.H. Yoo; J.H. Chung; S.G. Chang
12/28/2015
Alcohol dehydrogenase 2; Coronary artery disease; Meta-analysis; Polymorphism

We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and 5016 controls in 12 case-control ... more

L.L. Zhang; Y.Q. Wang; B. Fu; S.L. Zhao; Y. Kui

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