Research Article

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07/28/2015
Gastric cancer; Meta-analysis; MicroRNA; Polymorphism

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

Y.P. Gu; Q.Y. Yuan; H. Zhang; C.J. Wang; F. Zhou
11/23/2015
Gastric cancer; hOGG1 gene; Meta-analysis; Polymorphism; Risk association study

The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address ... more

W.G. Hu; R.J. Pan; W. Cai; Z.T. Wang; Z.G. Zhu
10/29/2015
Cervical cancer; IL-17; Interleukin 17; rs2275913G>A; rs763780T>C; Single nucleotide polymorphism

We conducted a case-control study with a relatively large sample size, and investigated the association between rs2275913G>A and rs763780T>C and the risk of cervical cancer. Three hundred and six newly diagnosed patients with histologically confirmed cervical cancer and 354 cancer-free control subjects were recruited from the Forestry General Hospital between May 2011 and May 2014 ... more

L.X. Sun; X.B. Wang; X.J. Huang
09/02/2016
Asthma; IL-10; IL-17; Smad protein; TGF-β

In this research, compound Maqin decoction (CMD) has been shown to positively affect in airway inflammation of asthma models. We evaluated the effects of CMD on the expression of transforming growth factor (TGF)-β1/Smad proteins, interleukin (IL)-17, and IL-10 in lung tissue of asthmatic rats. Asthma was induced in a rat model using ovalbumin. After a 4-week treatment with CMD, rats were ... more

Y.H. Xie; X.P. Li; Z.X. Xu; P. Qian; X.L. Li; Y.Q. Wang; Y.H. Xie; X.P. Li; Z.X. Xu; P. Qian; X.L. Li; Y.Q. Wang
07/27/2015
Chinese population; Familial aggregation; Gene polymorphism; Liver cancer; Risk factors; Transforming growth factor-β1

The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms in TGF ... more

P.Q. Wan; J.Z. Wu; L.Y. Huang; J.L. Wu; Y.H. Wei; Q.Y. Ning
12/29/2015
Bronchiolitis; Chinese population; ORMDL3 gene; Respiratory viruses; Single nucleotide polymorphisms

Recent studies revealed common genetic risks for both viral bronchiolitis and asthma. Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma. We conducted a case-control study examining the associations between ORMDL3 polymorphisms (rs7216389, rs12603332, and rs11650680) and bronchiolitis susceptibility/viral findings among ... more

X.T. Liu; L. Ren; L.L. Zhou; Q.Y. Xiao; Y. Deng; E.M. Liu
12/28/2015
Chinese population; Graves’ disease; Heat shock protein 70; Polymorphisms

Graves’ disease (GD) is a common autoimmune disease mainly affecting the thyroid. However, the correlation between the development of GD and HSP70 alleles has not been reported in the Chinese population. Therefore, the aim of this study was to investigate the association between HSP70 polymorphisms and GD in the Chinese population. A total of 153 patients with GD treated ... more

Y.P. Wang; Z. Tang; B.K. Peng; Q. Zhen; S.L. Zhou; X.F. Jin
12/21/2015
Chinese population; NLRP3 polymorphism; Type 2 diabetes

We conducted a case-control study to investigate the role of three common polymorphisms (rs10754558, rs7512998, and rs12137901) of the gene NLR family, pyrin domain containing 3 (NLRP3) in the development of type 2 diabetes mellitus (T2DM). Between May 2013 and May 2014, 385 patients with T2DM and 401 control subjects were enrolled in our study. Genotyping of the three NLRP3 ... more

S. Wang; F. Fang; W.B. Jin; X. Wang; X.S. Zheng
06/03/2016
Breast cancer; Chinese population; Polymorphism; XPG

We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of XPG rs2094258, rs751402, and rs17655 was performed using ... more

S.H. Ma; F.H. Ling; Y.X. Sun; S.F. Chen; Z. Li; S.H. Ma; F.H. Ling; Y.X. Sun; S.F. Chen; Z. Li
07/17/2015
Gastric cancer; Invasion; miR-221; Proliferation; Propofol

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel ... more

Z.T. Wang; H.Y. Gong; F. Zheng; D.J. Liu; X.Q. Yue

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