Research Article

Related GMR Articles

12/22/2015
Double-stranded RNA-activated protein kinase; High-mobility group box chromosomal protein 1; Inflammatory factor; Rheumatoid arthritis

The pathogenesis of rheumatoid arthritis (RA) is characterized by inflammation. We aimed to examine the roles of double-stranded RNA-activated protein kinase (PKR) and high-mobility group box chromosomal protein 1 (HMGB1) in a rat model of RA. Male SD rats were divided into three groups: control, RA model, and intervention (RA model plus treatment). The model of RA was made by injecting ... more

W.J. Wang; S.J. Yin; R.Q. Rong
12/02/2015
Genetic polymorphism; Matrix metalloproteinase-3; mRNA expression; Rheumatoid arthritis

Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled 80 RA patients and 80 healthy subjects. Enzyme- ... more

M.J. Ma; H.C. Liu; X.Q. Qu; J.L. Wang
12/29/2015
Fibroblast-like synoviocytes; Myeloid differentiation factor 88; Rheumatoid arthritis; Sinomenine; Tumor necrosis factor receptor associated factor-6

The effect of sinomenine (SIN) on the toll-like receptor (TLR) signal transduction pathway as well as the expression of myeloid differentiation factor 88 (MyD88) and tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) was investigated. SIN inhibition of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) proliferation and RA cartilage and subchondral bone ... more

H.C. Zhang; M.X. Liu; E.P. Wang; Z. Lin; G.F. Lv; X. Chen
10/09/2015
Coronary heart disease; Han Chinese population; Matrix metalloproteinase; Polymorphism

Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case ... more

C.M. Wang; H.D. Ye; Y.R. Li; Q.X. Hong; L.L. Tang; A.N. Zhou; M.Q. Xu; S.W. Duan
11/25/2015
Cloning; Penta D allele; Sequencing; Short tandem repeat; Zhuang nationality

Kinship testing of a father and his son from Guangxi, China, the location of the Zhuang minority people, was performed using the PowerPlex® 18D System with a short tandem repeat typing kit. The results indicated that both the father and his son had an off-ladder allele at the Penta D locus, with a genetic size larger than that of the maximal standard allelic ladder. To further identify ... more

Y.L. Yang; J.G. Wang; D.X. Wang; W.Y. Zhang; X.J. Liu; J. Cao; S.L. Yang
07/29/2016
Congenital cataract; Genes; Loci; Sequencing; Sex-linked inheritance

Congenital cataract is a common cause of blindness in children; however, its pathogenesis remains unclear. Genetic factors have been shown to play an important role in the pathogenesis of congenital cataract. The current genetic models of congenital cataract include autosomal dominant, autosomal recessive, and sex-linked inheritance. Sex-linked congenital cataract could be inherited ... more

D.D. Zhang; J.Z. Du; J. Topolewski; X.M. Wang; D.D. Zhang; J.Z. Du; J. Topolewski; X.M. Wang
10/17/2016
Biotyping; Genetic and phylogenetic analysis; Immunocapture RT-PCR; PVYNTN; Sequencing; Serotyping

In Tunisia, potato virus Y (PVY) currently presents a significant threat to potato production, reducing tuber yield and quality. Three hundred and eighty-five potato samples (six different cultivars) collected in autumn 2007 from nine regions in Tunisia were tested for PVY infection by DAS-ELISA. The virus was detected in all regions ... more

M. Tayahi; C. Gharsallah; N. Khamassy; H. Fakhfakh; F. Djilani-Khouadja; M. Tayahi; C. Gharsallah; N. Khamassy; H. Fakhfakh; F. Djilani-Khouadja
08/27/2020
BAPA; Brucellosis; Calves; PCR; S19; Sequencing

Bovine brucellosis is a zoonotic disease that has considerable economic impact on the market of products such as meat and milk. As Brazil has one of the largest cattle herds in the world, this disease is a significant agricultural and public health concern. In 2001, Brazil launched the National Program of Control and Eradication of Animal Brucellosis and ... more

C. Mantovani; C.O. Soares; L.Rdos Santos; G.M.S. Rosinha
09/25/2015
ASB15 gene; Chicken; Growth and carcass traits; Single nucleotide polymorphism

ASB15 is a member of the ankyrin repeat and suppressor of cytokine signaling box family, and is predominantly expressed in skeletal muscle. In the present study, an F2 resource population of Gushi chickens crossed with Anka broilers was used to investigate the genetic effects of the chicken ASB15 gene. Two single nucleotide polymorphisms (SNPs) (rs315759231 A>G and ... more

Y.C. Wang; R.R. Jiang; X.T. Kang; Z.J. Li; R.L. Han; J. Geng; J.X. Fu; J.F. Wang; J.P. Wu
09/22/2015
Chemotherapy; ERCC1; ERCC2; Osteosarcoma; Overall survival; Single nucleotide polymorphism

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess ... more

Q. Zhang; L.Y. Lv; B.J. Li; J. Zhang; F. Wei

Pages