Research Article

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Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-dependent manner and was observed to induce ... more

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08/14/2015
Dental pulp cells; Mineralization; Platelet-rich plasma; Proliferation; Washed platelets

We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L PRP or WPLTs was added to 4th generation cells. The MTS method was used to determine cell proliferation. Alizarin red staining was used ... more

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Adiponectin; Adipose tissue; Migration; Preadipocyte; Proliferation; Wound healing

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Apoptosis; Hepatocellular carcinoma; Proliferation; ST2825

The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cells as well as the potential mechanism and clinical significance of ST2825 in the treatment of HCC. Immunohistochemical staining with an MyD88 antibody was performed on tissues from 80 ... more

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Calf testis; Germline stem cells; Glial cell line-derived neurotrophic factor; Leukemia-inhibitory factor; Proliferation; Sperm differentiation

Germline stem cells are the only such capable of transmitting genetic information in vivo. The isolation and culture of these cells in vitro provide a unique model to understand sperm differentiation and hence, spermatogenesis and male fertility. In this study, we isolated, purified, and cultured germline stem cells from the testes of newborn ... more

P. Zheng; H. Huang; Y.G. Tian; Y. Zeng; E.O. Adegoke; X. Wang; G.X. Zhang; P. Zheng; H. Huang; Y.G. Tian; Y. Zeng; E.O. Adegoke; X. Wang; G.X. Zhang
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Apoptosis; miR-1; Proliferation; Vestibular schwannoma

A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover, miR-1 ... more

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01/24/2022
Apoptosis; Autophagy; Mesothelin; Mesothelioma; Proliferation; Survival

It is known that mesothelin (MSLN) is overexpressed in some cancers, and that it plays a role in cell growth through Wnt family member 1 protein. Malignant transformation usually occurs with disruption of autoregulation of autophagy-related genes. We examined the effect of MSLN on survival and clinicopathological features in mesothelioma cases, as well as ... more

A. Aksoy; A. Varoglu; E.E. Onalan; A. Tektemur; G. Artas

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