Research Article

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09/21/2015
COL1A1; Gene polymorphism; Meta-analysis; Osteoporosis

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the ... more

K.H. Yu; J. Tang; C.Q. Dai; Y. Yu; J.J. Hong
09/08/2015
DQA gene; Gene polymorphism; Haplotype reconstruction; Piglet diarrhea; Swine leukocyte antigen

In this study, 290 Chinese native Yantai black pig piglets were investigated to identify gene polymorphisms, for haplotype reconstruction, and to determine the association between piglet diarrhea and swine leukocyte antigen (SLA) class II DQA exons 2, 3, and 4 by polymerase chain reaction-single stranded conformational polymorphism and cloning sequencing. The results showed that ... more

X.Y. Huang; Q.L. Yang; J.H. Yuan; S.B. Gun
08/19/2015
Cervical carcinoma; Gene polymorphism; Meta-analysis; XRCC1

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and ... more

D.Y. Liu; H.C. Liang; X.M. Xiao
08/10/2015
APOA5/A4/C3/A1 gene cluster; Apolipoprotein B; Dyslipidemia; Gene polymorphism

We determined the alleles of ten single nucleotide poly­morphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 pa­tients and 250 normal controls. All ... more

H.J. Ou; G. Huang; W. Liu; X.L. Ma; Y. Wei; T. Zhou; Z.M. Pan
08/07/2015
AT1R; Gene polymorphism; Heart failure; Meta-analysis

The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the ... more

J.A. Zhang; J.R. Li; Y.J. Qiao
07/27/2015
Chinese population; Familial aggregation; Gene polymorphism; Liver cancer; Risk factors; Transforming growth factor-β1

The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms in TGF ... more

P.Q. Wan; J.Z. Wu; L.Y. Huang; J.L. Wu; Y.H. Wei; Q.Y. Ning
01/04/2016
CYP1 A1; Gene polymorphism; Non-small cell lung cancer; Smoking

Many studies have shown that genetic factors, environmental factors, and bad living habits, especially smoking, are risk factors for lung cancer. However, not all smokers develop lung cancer, which may be related to different genetic backgrounds. Currently, most research has investigated the GSTM1, XRCC1, XRCC3, CYP2D6, and C188T genes. Little ... more

Y.Q. Xie; J.M. Chen; Y. Liu
12/29/2015
Cervical cancer; COMT; CYP1A1; Gene polymorphism

The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were analyzed: a) 81 ... more

J.P. Kleine; C.M. Camargo-Kosugi; C.V. Carvalho; F.C. Silva; I.D.C.G. Silva
12/16/2015
Angiotensin-converting enzyme; Gene polymorphism; Liver fibrosis; Turkish population

Chronic viral hepatitis B, chronic viral hepatitis C, non-alcoholic steatohepatitis, alcoholic liver disease, autoimmune hepatitis, primary biliary cirrhosis, and secondary biliary cirrhosis are important health issues worldwide. While an association between angiotensin-converting enzyme gene insertion/deletion (ACE gene I/D) polymorphism and liver fibrosis has been demonstrated in rat ... more

N.K. Turhan; U. Ilikhan; A.C. Hamamcioglu; Y. Ustundag; A. Dursun; F. Kokturk
12/07/2015
Atrial fibrillation; Gene polymorphism; KCNE1 (G38S); Uygur population

Current resources to support genetic screening among the Uygur population in Xinjiang territory for atrial fibrillation (AF) have not been well established and large-scale epidemiological analyses are needed. Using patients from the Xinjiang Uygur population as subjects, and the delayed rectifier potassium channel KCNE1 and its associated polymorphism G38S (rs1805127) as the candidate gene, we ... more

N. Wugeti; G. Yu-Jun; S. Juan; A. Mahemuti

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