Research Article

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B.L. Shen; Q.S. Qu; S.Z. Miao; Y.X. Zhang
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Polymorphism; Renal cell carcinomas; Vascular endothelial growth factor

We conducted a case-control study in a Chinese population to assess whether 5 common single-nucleotide polymor­phisms in the vascular endothelial growth factor gene (VEGF) affect the risk of renal cell carcinoma (RCC). The study population in­cluded 266 RCC patients who were newly diagnosed and histologi­cally confirmed to have RCC as well as 532 cancer-free controls. Genotyping ... more

W. Xian; H. Zheng; W.J. Wu
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Meta-analysis; Polymorphism; Psoriasis; Vascular endothelial growth factor

The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms confer susceptibil­ity to psoriasis. Meta-analyses were conducted to examine the asso­ciations between the +405 C/G, -460 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and psoriasis using allele contrast and reces­sive, dominant, and additive models. Seven studies ... more

Y.H. Lee; G.G. Song
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Cancer; Meta-analysis; Polymorphism; Vascular endothelial growth factor

The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a meta-analysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. We searched ... more

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DNA repair genes; Osteosarcoma; Overall survival; Polymorphism

We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed ... more

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Clinical outcome; ERCC1; ERCC2; Osteosarcoma; Polymorphism

We aimed to evaluate the influence of four SNPs in ERCC1 and ERCC2 on the response to cisplatin-based treatment and on clinical outcome in patients with osteosarcoma. We identified 186 patients with osteosarcoma diagnosed between April 2009 and April 2011 who were eligible for inclusion in our study. Genotyping of ERCC1 rs11615, rs3212986, and rs2298881; and ... more

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CSN3 gene; Donkey; Horse; Polymorphism

The aims of this study were to assess the genetic variability in the exon 1 of the κ-casein gene in four Italian horse populations (Italian Saddle horse, Italian Trotter, Italian Heavy Draught horse, and Murgese horse) and in a sample of Martina Franca donkey by estimating genotype, allele and haplotype frequencies, as well as several population genetic indices. Genotyping of the selected ... more

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B7-H3; Nude mice; Osteosarcoma; T cell

Immune cells might participate in the ontogenesis of osteosarcoma. B7-H3 is a new discovered T cell co-stimulatory molecule that was found to be overexpressed in malignant tumors. We aimed to investigate the dynamic expression level of B7-H3 in nude mice with osteosarcoma. A nude mouse osteosarcoma model was successfully established. B7-H3 expression and distribution changes in the early, ... more

S.J. Yin; W.J. Wang; J.Y. Zhang
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Estrogen receptor; Thin endometrium; Vascular endothelial growth factor

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A.W. Le; L. Shan; Z.H. Wang; X.Y. Dai; T.H. Xiao; R. Zuo
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Microwave ablation; Non-small cell lung cancer; Vascular endothelial growth factor

We aimed to analyze the changes of serum vascular endothelial growth factor (VEGF) before and after microwave ablation (MWA) in patients with stage IIIB-IV non-small cell lung cancer (NSCLC), and to observe the effects of MWA combined with chemotherapy on short-term therapeutic efficacy and long-term survival. Concentrations of serum VEGF in 20 healthy subjects were considered as controls ... more

Y.H. Sun; P.Y. Song; Y. Guo; M. Pang; W.N. He; W.H. Zhang; L.J. Sheng

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