Research Article

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12/29/2015
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
12/29/2015
Cardiovascular disease; Coronary artery disease; Gene; Meta-analysis; Polymorphism; PPARγ2

This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of ... more

Y. Li; J. Zhu; J.Q. Ding
12/28/2015
Alcohol dehydrogenase 2; Coronary artery disease; Meta-analysis; Polymorphism

We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and 5016 controls in 12 case-control ... more

L.L. Zhang; Y.Q. Wang; B. Fu; S.L. Zhao; Y. Kui
12/17/2015
Meta-analysis; Polymorphism; Tumor necrosis factor-α; Vitiligo

Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the ... more

G. Nie; J.H. Qi; C.W. Huang; T. Yang; N. Shi; Y.J. Chen
12/17/2015
Meta-analysis; NAT2; Pancreatic cancer; Polymorphism; susceptibility

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to assess this relationship ... more

J.X. Liang; W. Gao; Y. Liang; X.M. Zhou
12/14/2015
Meta-analysis; Polymorphism; rs7903146; T2DM; TCF7L2

Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for evidence-based ... more

X.H. Liu; C.G. Xie; Y. An; X.X. Zhang; W.B. Wu
12/02/2015
Case-control study; Crohn’s disease; Meta-analysis; Polymorphism; Tumor necrosis factor-α

We investigated the associations between 2 major tumor necrosis factor-α (TNF-α) polymorphisms, rs1799724 C>T and rs1800629 G>A, and the susceptibility to Crohn’s disease (CD) using a meta-analysis framework. The PubMed, EBSCO, Ovid, Wiley, Web of Science, WANFANG, and VIP databases (last updated search in October 2014) were comprehensively searched for relevant ... more

Y.Q. Mao; S.Q. Dong; M. Gao
11/30/2015
Alcohol dehydrogenase 1C; Meta-analysis; Pancreatitis risk; Polymorphism

Numerous studies have focused on the relationship be­tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal­ysis to more precisely estimate this association. Relevant publications were searched in several widely used ... more

F. Fang; J. Pan; G.H. Su; L.X. Xu; G. Li; Z.H. Li; H. Zhao; J. Wang
11/25/2015
Angiotensin II type-1 receptor; Breast cancer; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through ... more

L. Li; F. Wang; P.W. Lv; M.Z. Zhu; J.J. He; G.C. Guo; Y.T. Gu; M.L. Han
11/23/2015
Gastric cancer; hOGG1 gene; Meta-analysis; Polymorphism; Risk association study

The association between the human 8-oxoguanine glycosylase 1 (hOGG1) gene Ser326Cys polymorphism (rs1052133) and gastric cancer has been widely evaluated, yet a definitive answer to whether this association exists is lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address ... more

W.G. Hu; R.J. Pan; W. Cai; Z.T. Wang; Z.G. Zhu

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